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Peptide Therapy GuideClear peptide education

Understand the source comparison

Best Peptides for Body Recomp Stack: Protocol Comparison

Fat Loss Priority Tirzepatide 10–15mg/wk + Tesofensine 0.25–0.5mg/day GLP-1/GIP appetite suppression + monoamine reuptake thermogenesis 12–18% body fat reduction, 20–25% lean mass loss of total weight Weekly (tirzepatide) + daily oral (tesofensine) Maximum fat

No winner is assigned.

This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.

  • Fat Loss Priority
  • Tirzepatide 10–15mg/wk + Tesofensine 0.25–0.5mg/day
  • GLP-1/GIP appetite suppression + monoamine reuptake thermogenesis
  • 12–18% body fat reduction, 20–25% lean mass loss of total weight
  • Weekly (tirzepatide) + daily oral (tesofensine)
  • Maximum fat loss velocity but significant muscle catabolism without resistance training and high protein intake (2.2g/kg)
  • Balanced Recomp
  • Semaglutide 1–2mg/wk + CJC-1295/Ipamorelin 200mcg each 5x/wk
  • GLP-1 deficit + GH/IGF-1 anabolic signaling
  • 10–15% body fat reduction with lean mass preservation or 1–3% gain
  • Weekly (semaglutide) + 5x weekly (peptides)
  • Best risk-reward ratio for simultaneous fat loss and muscle retention. Requires consistent training stimulus
  • Lean Gain Focus
  • MK-677 20mg/day + CJC-1295 300mcg 3x/wk
  • Ghrelin mimetic + sustained GH elevation
  • 3–6% body fat reduction, 4–8% lean mass gain
  • Daily oral (MK-677) + 3x weekly (CJC-1295)
  • Produces muscle gain but minimal fat loss without caloric deficit. Appetite increase from MK-677 opposes fat reduction
  • Metabolic Optimization
  • Mazdutide 3.6mg/wk + SLU-PP-332 10mg/day + Hexarelin 100mcg 2x/day
  • Dual GIP/GLP-1 + ERRα mitochondrial activation + pulsatile GH
  • 15–20% body fat reduction, lean mass stable or modest gain
  • Weekly (mazdutide) + daily oral (SLU-PP-332) + 2x daily (hexarelin)
  • Experimental but mechanistically sound. Combines three independent fat oxidation pathways with anabolic protection