Guide library
Plain-language education with dates, authors and original source links where available.
This image depicts a conventional CRISPR-Cas9 system. The Cas9 enzyme acts like a wrench, and specific RNA guides act as different socket heads. Conventional CRISPR-Cas9 systems act continuously, raising the r…
Read guide →Candidate: ATYR1923 Type: Fusion protein consisting of the immuno-modulatory domain of histidyl tRNA synthetase fused to the FC region of a human antibody. Acts as a selective modulator of neuropilin-2 that do…
Read guide →Sanofi’s global vaccines unit Sanofi Pasteur will partner with Translate Bio to develop mRNA vaccines for up to five undisclosed infectious disease pathogens, through a collaboration that the mRNA therapeutics…
Read guide →Researchers in the laboratories of Hidde Ploegh, Ph.D., Boston Children's Hospital, and Harvey Lodish, Ph.D., Whitehead Founding Member, have prevented and alleviated two autoimmune diseases —multiple sclerosi…
Read guide →Pulmocide raised $30.4 million in a Series B round of financing to support the early clinical development of its lead inhaled drugs against respiratory syncytial virus (RSV) and pulmonary aspergillosis. The fu…
Read guide →Sangamo Therapeutics will eliminate more than a quarter (27%) of its U.S. workforce—some 120 jobs—and refocus its pipeline on three specialties, as the genomic medicine developer works to bounce back from bein…
Read guide →The “Lab-on-a-Molecule” team at the Wyss Institute is using DNA nanoswitch technology to develop an in vitro, high-throughput, platform to identify compounds for drug discovery. The nanoswitch is a nanoscale t…
Read guide →GEN recently spoke with Ryan Bomgarden, PhD, senior R&D manager at Thermo Fisher Scientific, about the many advances being made in understanding protein-protein interactions as well as what the future holds. G…
Read guide →Gene delivery is, arguably, the biggest bottleneck in gene therapy. Adeno-associated viruses (AAVs) are the historical mainstay, but they are expensive to manufacture and have payload limits and immunological …
Read guide →The ups and downs of stock prices are often likened to a roller-coaster ride—and this past month, investors in Cytokinetics (CYTK) have seen all too well the ups, and the downs, of that metaphor. The big ride …
Read guide →Some are saying that mRNA medicines—mRNA vaccines and mRNA therapeutics alike—will open a golden era of medicine. And the enthusiasm is catching. Following the precedent set by the first mRNA-based COVID-19 va…
Read guide →Most neurodegenerative diseases, including dementias, involve proteins aggregating into filaments called amyloids. For most of these diseases researchers have identified the proteins that aggregate, allowing t…
Read guide →New research from the Australian National University (ANU) has found that a protein called DECTIN-1, programmed to protect the body from fungal infections, is also responsible for exacerbating the severity of …
Read guide →Identifying the risks of a potentially negative immune response to an mRNA therapeutic before it is delivered to patients may now be possible thanks to new research from scientists in the Medical Research Coun…
Read guide →Scientists at Harvard Medical School have shown for the first time that the common skin bacterium, Staphylococcus aureus, can cause itching by acting directly on nerve cells. The new findings, based on researc…
Read guide →Director of Product Research Scripps Laboratories The COVID-19 pandemic and geopolitical conflict in Eastern Europe have done irreparable damage to the underpinnings of the clinical diagnostic industry. These …
Read guide →Researchers at the Karolinska Institute have used DNA origami to demonstrate how an important cell receptor can be activated in a previously unknown way. The new study provides insight into how the Notch signa…
Read guide →May 1, 2015 (Vol. 35, No. 9) Using NanoBRET Technology to Follow Changes in Intracellular Protein Binding Events Significant advances in the understanding of the human proteomics network have advanced knowledg…
Read guide →Patricia F. Fitzpatrick Dimond Ph.D. Technical Editor of Clinical OMICs President of BioInsight Communications Alzheimer’s Research Struggles to Overcome its 99% Drug Failure Rate Over the Past Decade In Novem…
Read guide →Epitope information is increasingly being used to understand the mechanism of action (MoA) of therapeutic monoclonal antibodies (mAbs), as well as to overcome the mounting challenges of patenting them. Differe…
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