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Tuna dark muscle peptides modulate host iron metabolism ...
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Show {{imgMenuList.length - 9}} more figures Hide {{imgMenuList.length - 9}} figures Show {{tableMenuList.length - 5}} more tables Hide {{tableMenuList.length - 5}} tablesResearch Article | Open Access
Jiayi Xiongb,#, Zhixiang Baib, Yang Qinb, Chenyang Lua,b, Jun Zhoua,b( ), Ye Lia,b, Tinghong Minga,b, Zhen Zhanga,b, Xiurong Sua,b( )
a
State Key Laboratory for Managing Biotic and Chemical Threats to the Quality and Safety of Agro-products, Ningbo University, Ningbo 315832, Chinab
School of Marine Science, Ningbo University, Ningbo 315832, China# These authors contributed equally to this work.
Peer review under responsibility of Beijing Academy of Food Sciences.
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Highlights
• The tuna dark muscle peptides might be used as a prebiotic to ameliorate iron deficient anemia.
• The amelioration was related to the regulation of gut microbiota, which verified by FMT.
• The tuna dark muscle peptides can regulate the dysbiosis of gut microbiota induced by iron deficient anemia.
• The study provides a theoretical basis for tuna dark muscle peptides as functional foods.
Abstract
Iron deficiency anemia (IDA) is a nutritional deficiency disease with a high incidence rate worldwide. Bioactive peptides are safe and effective, have multiple functions and can serve as potential candidates for alleviating IDA. In this study, the anti-anemia effects of tuna dark muscle peptides were explored in a diet-induced IDA mouse model. The results showed that tuna dark muscle peptides alleviated the IDA phenotype, oxidative stress and iron metabolism. In addition, tuna dark muscle peptides reversed gut microbiota dysbiosis in IDA mice. Furthermore, the transplanted fecal microbiota from tuna dark muscle peptide-treated mice also alleviated IDA symptoms and regulated iron metabolism and the gut microbiota, indicating that the anti-anemic effects were at least partially mediated by the gut microbiota. Thus, we identified a new and safe prebiotic material to alleviate IDA and provided ideas for the development of peptides. At the same time, these data also provided a theoretical basis for fecal microbiota transplantation to alleviate IDA.
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Food Science and Human Wellness
Article number: 9250047
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Cite this article:
Han J, Xiong J, Bai Z, et al. Tuna dark muscle peptides modulate host iron metabolism in the intestine through the gut microbiota and ameliorate iron deficiency anemia. Food Science and Human Wellness, 2025, 14(2): 9250047. https://doi.org/10.26599/FSHW.2024.9250047
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Received: 19 May 2023
Revised: 20 June 2023
Accepted: 20 July 2023
Published: 10 March 2025
© 2025 Beijing Academy of Food Sciences. Publishing services by Tsinghua University Press.
This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).