Educational guide
The Ordinary Argireline Solution 10% Versus Depology Peptide Complex 10% Wrinkle Defense Serum
The Ordinary Argireline Solution 10% Versus Depology Peptide Complex 10% Wrinkle Defense Serum This anti-aging serum is formulated around Acetyl Hexapeptide-8 to soften the look of wrinkles. This anti-aging serum is formulated around Acetyl Hexapeptide-8 and P
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The Ordinary Argireline Solution 10% Versus Depology Peptide Complex 10% Wrinkle Defense Serum
This anti-aging serum is formulated around Acetyl Hexapeptide-8 to soften the look of wrinkles.
This anti-aging serum is formulated around Acetyl Hexapeptide-8 and Palmitoyl Tripeptide-5 to soften the look of wrinkles.
What's inside
Key Ingredients
Benefits
Concerns
No concerns
Ingredients Side-by-side
Water
Propanediol
Acetyl Hexapeptide-8
Trisodium Ethylenediamine Disuccinate
Gellan Gum
Sodium Chloride
Isoceteth-20
Dimethyl Isosorbide
Potassium Sorbate
Phenoxyethanol
Chlorphenesin
Water, Propanediol, Acetyl Hexapeptide-8, Trisodium Ethylenediamine Disuccinate, Gellan Gum, Sodium Chloride, Isoceteth-20, Dimethyl Isosorbide, Potassium Sorbate, Phenoxyethanol, Chlorphenesin
Isopentyldiol
1,2-Hexanediol
Panthenol
Hydroxyethyl Urea
Butylene Glycol
Caprylyl Glycol
Glycerin
Sodium Hyaluronate
Ficus Carica Fruit Extract
Centella Asiatica Extract
Ceramide NP
Hydrogenated Lecithin
Anthemis Nobilis Flower Oil
Tocopherol
Houttuynia Cordata Extract
Tocopheryl Acetate
Ascorbic Acid Polypeptide
Ammonium Acryloyldimethyltaurate/Vp Copolymer
Tromethamine
Carbomer
Octyldodeceth-16
Ethylhexylglycerin
Acrylates/C10-30 Alkyl Acrylate Crosspolymer
Disodium EDTA
Palmitoyl Tripeptide-5
Pinus Strobus Bark Extract
Hexapeptide-9
Maltodextrin
Lavandula Angustifolia Oil
Linalool
Water, Isopentyldiol, 1,2-Hexanediol, Panthenol, Hydroxyethyl Urea, Butylene Glycol, Propanediol, Caprylyl Glycol, Glycerin, Sodium Hyaluronate, Ficus Carica Fruit Extract, Centella Asiatica Extract, Acetyl Hexapeptide-8, Ceramide NP, Hydrogenated Lecithin, Anthemis Nobilis Flower Oil, Tocopherol, Houttuynia Cordata Extract, Tocopheryl Acetate, Ascorbic Acid Polypeptide, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Tromethamine, Carbomer, Octyldodeceth-16, Ethylhexylglycerin, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Disodium EDTA, Palmitoyl Tripeptide-5, Pinus Strobus Bark Extract, Hexapeptide-9, Maltodextrin, Lavandula Angustifolia Oil, Linalool
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Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Acetyl Hexapeptide-8 (also known as Argireline) is a synthetic hexapeptide that is often called a "topical Botox alternative".
It works by mimicking how Botox relaxes muscles; it interferes with the signaling process that tells your facial muscles to contract. This can help soften expression lines like forehead wrinkles or crow's feet over time.
The comparison to Botox does have limits because the molecule is water-loving and relatively large.
Acetyl Hexapeptide-8 has a hard time absorbing deeply enough through the skin's outer barrier to actually reach the muscles.
So whether it truly works the way Botox does at a biological level is still up for debate, but early clinical outcomes are fairly encouraging.
A 12 week human study of a multi-ingredient regimen containing this ingredient saw:
While some studies have observed improvements in wrinkle appearance, it is important to note that more consistent results are seen in multi-ingredient formulations (vs just Acetyl Hexapeptide-8 alone).
Some research studies also used higher concentrations (up to 10%) while this ingredient is usually found in concentrations up to 0.005% in leave-on formulations.
Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.
It’s often used to:
Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!