TFF1 protein expression summary — Peptide Therapy Guide

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TFF1 INFORMATION
Proteini	Trefoil factor 1
Gene namei	TFF1 (BCEI, D21S21, HP1.A, HPS2, pNR-2, pS2)
Protein classi	Cancer-related genes Plasma proteins
Protein evidence	Evidence at protein level (all genes)
Number of transcriptsi	1
Protein interactions	Interacting with 9 proteins

PROTEIN EXPRESSION AND LOCALIZATION
Tissue profilei	Selective cytoplasmic expression in the superficial layer of gastric mucosa and goblet cells.
Tissue specificity (MS)	Not detected
Cell type specificity (DVP)	Not detected
Subcellular locationi	Not available
Predicted locationi	Secreted
Extracellular locationi	Secreted to digestive system

TISSUE RNA EXPRESSION
Tissue specificityi	Tissue enriched (Stomach)
Tissue expression clusteri	Stomach - Digestion (mainly)
Brain specificityi	Not detected in human brain
Brain expression clusteri	Not detected - no cluster assigned

CELL TYPE RNA EXPRESSION
Single cell type specificityi	Cell type enriched (Foveolar cells)
Single cell type expression clusteri	Foveolar cells - Mucosal defense (mainly)
Tissue cell type classificationi	Cell type enriched (Colon - Colon enterocytes, Minor Salivary Gland - Minor salivary glandular cells, Pancreas - Ductal cells, Stomach - Gastric mucous cells)
Immune cell specificityi	Not detected in immune cells
Immune cell expression clusteri	Not detected - no cluster assigned

CANCER & CELL LINES
Prognostic summary	TFF1 is a prognostic marker in Kidney renal clear cell carcinoma, Liver hepatocellular carcinoma
Cancer specificityi	Cancer enhanced (Pancreatic Adenocarcinoma, Stomach Adenocarcinoma)
Cell line expression clusteri	Breast cancer - Unknown function (mainly)
Cell line specificityi	Cancer enriched (Breast cancer)

PROTEINS IN BLOOD
Upregulated in diseasei	Staphylococcus aureus bacteremia, Schizophrenia, Bipolar disorder, Pneumococcal pneumonia, Alcohol-related liver disease, Hepatocellular cancer, Streptococcal soft tissue infection, Viral hepatitis related cirrhosis, E.coli pyelonephritis, Pediatric retinoblastoma, Pancreatic cancer, MASLD, Chronic liver disease, Pediatric kidney tumor, Systemic lupus erythematosus, HIV, Acute coronary syndrome, Myeloma, Malaria, Pediatric CNS tumor, Systemic sclerosis, Bacterial gastroenteritis, Myositis, Acute venous thromboembolism
Disease prediction modeli	Bipolar disorder (Healthy), Viral hepatitis related cirrhosis (Healthy), Abdominal aortic aneurysm (Healthy), Schizophrenia (Healthy,All other diseases), MASLD (Healthy,All other diseases), Pancreatic cancer (Healthy,All other diseases)
Secretome annotationi	Secreted to digestive system
Detected in blood by immunoassayi	No (not applicable)
Detected in blood by mass spectrometryi	Yes
Proximity extension assayi	Data available
SomaScani	Data available

PROTEIN FUNCTION
Protein function (UniProt)i	Stabilizer of the mucous gel overlying the gastrointestinal mucosa that provides a physical barrier against various noxious agents. May inhibit the growth of calcium oxalate crystals in urine.... show less
Molecular function (UniProt)i	Growth factor
Gene summary (Entrez)i	Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008]... show less

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