Independent education resourceInformation here does not replace care from a qualified health professional.
Peptide Therapy GuideClear peptide education

Educational guide

Somethinc Hyaluronic 9+ Advanced + B5 Serum Versus AMPLE:N Peptide Shot Ampoule 2x

Somethinc Hyaluronic 9+ Advanced + B5 Serum Versus AMPLE:N Peptide Shot Ampoule 2x This hydrating serum is formulated around Panthenol and Sodium Hyaluronate to hydrate skin and strengthen the skin barrier. This anti-aging ampoule is formulated around Niacinam

Written by Peptide Therapy Guide Editorial Team
For education only

This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.

Somethinc Hyaluronic 9+ Advanced + B5 Serum Versus AMPLE:N Peptide Shot Ampoule 2x

This hydrating serum is formulated around Panthenol and Sodium Hyaluronate to hydrate skin and strengthen the skin barrier.

This anti-aging ampoule is formulated around Niacinamide and Adenosine to soften the look of wrinkles and refine skin texture.

What's inside

Key Ingredients

Benefits

Ingredients Side-by-side

Onsen-Sui

Water

Butylene Glycol

Dipropylene Glycol

Glycereth-26

Methyl Gluceth-20

Pentylene Glycol

Panthenol

Chondrus Crispus Extract

Glucose

Chlorella Vulgaris Extract

C12-14 Pareth-12

Saccharum Officinarum Extract

Fructose

Fructooligosaccharides

Caprylyl Glycol

Carbomer

Ammonium Acryloyldimethyltaurate/Vp Copolymer

Tromethamine

Sodium Hyaluronate

Ethylhexylglycerin

Hyaluronic Acid

Sodium Phytate

Plumeria Alba Flower Oil

Hydrolyzed Hyaluronic Acid

Hydroxypropyltrimonium Hyaluronate

Hydrolyzed Sodium Hyaluronate

Sodium Acetylated Hyaluronate

PEG-9 Diglycidyl Ether/Sodium Hyaluronate Crosspolymer

Potassium Hyaluronate

Propanediol

Tocopherol

Dimethylsilanol Hyaluronate

Sodium Benzoate

1,2-Hexanediol

Onsen-Sui, Water, Butylene Glycol, Dipropylene Glycol, Glycereth-26, Methyl Gluceth-20, Pentylene Glycol, Panthenol, Chondrus Crispus Extract, Glucose, Chlorella Vulgaris Extract, C12-14 Pareth-12, Saccharum Officinarum Extract, Fructose, Fructooligosaccharides, Caprylyl Glycol, Carbomer, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Tromethamine, Sodium Hyaluronate, Ethylhexylglycerin, Hyaluronic Acid, Sodium Phytate, Plumeria Alba Flower Oil, Hydrolyzed Hyaluronic Acid, Hydroxypropyltrimonium Hyaluronate, Hydrolyzed Sodium Hyaluronate, Sodium Acetylated Hyaluronate, PEG-9 Diglycidyl Ether/Sodium Hyaluronate Crosspolymer, Potassium Hyaluronate, Propanediol, Tocopherol, Dimethylsilanol Hyaluronate, Sodium Benzoate, 1,2-Hexanediol

Glycerin

Niacinamide

Polyglycerin-3

Adenosine

Beta-Glucan

Arginine

Dipotassium Glycyrrhizate

Mallotus Japonicus Bark Extract

Yeast Extract

Helichrysum Arenarium Extract

Copper Tripeptide-1

Acetyl Tetrapeptide-2

Dextran

Hydroxyethylcellulose

Caramel

Glyceryl Acrylate/Acrylic Acid Copolymer

Trifluoroacetyl Tripeptide-2

Xanthan Gum

Boron Nitride

Pvm/Ma Copolymer

Agar

Gellan Gum

Calcium Alginate

Glucosylrutin

Palmitoyl Tripeptide-5

Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate

Magnesium Chloride

Disodium EDTA

Water, Glycerin, Butylene Glycol, Dipropylene Glycol, 1,2-Hexanediol, Niacinamide, Polyglycerin-3, Adenosine, Beta-Glucan, Arginine, Dipotassium Glycyrrhizate, Sodium Hyaluronate, Mallotus Japonicus Bark Extract, Yeast Extract, Helichrysum Arenarium Extract, Copper Tripeptide-1, Acetyl Tetrapeptide-2, Carbomer, Dextran, Hydroxyethylcellulose, Caramel, Glyceryl Acrylate/Acrylic Acid Copolymer, Trifluoroacetyl Tripeptide-2, Xanthan Gum, Boron Nitride, Pvm/Ma Copolymer, Agar, Gellan Gum, Calcium Alginate, Caprylyl Glycol, Glucosylrutin, Palmitoyl Tripeptide-5, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Magnesium Chloride, Disodium EDTA

Reviews

Be the first to review

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.

Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.

Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.

It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.

Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.

A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.

Dipropylene Glycol is a synthetically created humectant, stabilizer, and solvent.

This ingredient helps:

Dipropylene glycol is technically an alcohol, but it belongs to the glycol family (often considered part of the ‘good’ alcohols). This means it is hydrating and gentle on skin unlike drying solvent alcohols like denatured alcohol.

As a masking agent, Dipropylene Glycol can be used to cover the smell of other ingredients. However, it does not have a scent.

Studies show Dipropylene Glycol is considered safe to use in skincare.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

Connected reading

Helpful context for this guide

Source-derived material selected through this article’s indexed topics.

P

About the author

Peptide Therapy Guide Editorial Team

Editorial team for Peptide Therapy Guide.

View all articles →