AMPLE:N Peptide Shot Ampoule Versus AMPLE:N Peptide Shot Ampoule 2x

AMPLE:N Peptide Shot Ampoule Versus AMPLE:N Peptide Shot Ampoule 2x

This anti-aging ampoule is formulated around Niacinamide and Acetyl Hexapeptide-8 to soften the look of wrinkles.

This anti-aging ampoule is formulated around Niacinamide and Adenosine to soften the look of wrinkles and refine skin texture.

What's inside

Key Ingredients

Benefits

Concerns

No concerns

Ingredients Side-by-side

Water

Glycerin

Butylene Glycol

Dipropylene Glycol

Alcohol

PEG-32

Biosaccharide Gum-1

Niacinamide

Trehalose

Adenosine

Acetyl Hexapeptide-8

Arginine

Panthenol

Hydrogenated Lecithin

Beta-Glucan

Dipotassium Glycyrrhizate

Helichrysum Arenarium Extract

Yeast Extract

Palmitoyl Pentapeptide-4

Pearl Extract

Dimethicone

PEG-60 Hydrogenated Castor Oil

1,2-Hexanediol

Carbomer

Xanthan Gum

Titanium Dioxide

Sodium Palmitoyl Sarcosinate

Glyceryl Acrylate/Acrylic Acid Copolymer

Mica

Caramel

Agar

Calcium Alginate

Gellan Gum

Polysorbate 20

Propylene Glycol

Caprylyl Glycol

Glyceryl Caprylate

Phenylpropanol

Palmitoyl Oligopeptide

Lactic Acid

Polyvinyl Alcohol

Glycolic Acid

Phenoxyethanol

Parfum

Ethylhexylglycerin

Tetrasodium EDTA

Water, Glycerin, Butylene Glycol, Dipropylene Glycol, Alcohol, PEG-32, Biosaccharide Gum-1, Niacinamide, Trehalose, Adenosine, Acetyl Hexapeptide-8, Arginine, Panthenol, Hydrogenated Lecithin, Beta-Glucan, Dipotassium Glycyrrhizate, Helichrysum Arenarium Extract, Yeast Extract, Palmitoyl Pentapeptide-4, Pearl Extract, Dimethicone, PEG-60 Hydrogenated Castor Oil, 1,2-Hexanediol, Carbomer, Xanthan Gum, Titanium Dioxide, Sodium Palmitoyl Sarcosinate, Glyceryl Acrylate/Acrylic Acid Copolymer, Mica, Caramel, Agar, Calcium Alginate, Gellan Gum, Polysorbate 20, Propylene Glycol, Caprylyl Glycol, Glyceryl Caprylate, Phenylpropanol, Palmitoyl Oligopeptide, Lactic Acid, Polyvinyl Alcohol, Glycolic Acid, Phenoxyethanol, Parfum, Ethylhexylglycerin, Tetrasodium EDTA

Polyglycerin-3

Sodium Hyaluronate

Mallotus Japonicus Bark Extract

Copper Tripeptide-1

Acetyl Tetrapeptide-2

Dextran

Hydroxyethylcellulose

Trifluoroacetyl Tripeptide-2

Boron Nitride

Pvm/Ma Copolymer

Glucosylrutin

Palmitoyl Tripeptide-5

Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate

Magnesium Chloride

Disodium EDTA

Water, Glycerin, Butylene Glycol, Dipropylene Glycol, 1,2-Hexanediol, Niacinamide, Polyglycerin-3, Adenosine, Beta-Glucan, Arginine, Dipotassium Glycyrrhizate, Sodium Hyaluronate, Mallotus Japonicus Bark Extract, Yeast Extract, Helichrysum Arenarium Extract, Copper Tripeptide-1, Acetyl Tetrapeptide-2, Carbomer, Dextran, Hydroxyethylcellulose, Caramel, Glyceryl Acrylate/Acrylic Acid Copolymer, Trifluoroacetyl Tripeptide-2, Xanthan Gum, Boron Nitride, Pvm/Ma Copolymer, Agar, Gellan Gum, Calcium Alginate, Caprylyl Glycol, Glucosylrutin, Palmitoyl Tripeptide-5, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Magnesium Chloride, Disodium EDTA

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.

The way it works is fairly well mapped out:

Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.

The clinical backing is pretty solid too.

A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.

A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.

On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.

This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.

Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.

Agar is the vegan substitute for animal-gelatin. It helps thicken and improve the texture of cosmetics. It comes from cell-walls of red algae.

Arginine is a semi-essential amino acid. This just means our bodies can product a bit on its own, but sometimes needs a little boost from food sources.

It is a part of your skin's natural moisturizing factor (NMF), or the water-loving molecules in your outermost layer of skin (stratum corneum) that keeps everything hydrated and happy.

Here's an interesting thing about Arginine: your skin converts it into urea through the Krebs-Henseleit urea cycle. Urea is one of the most effective humectants your skin naturally produces.

A clinical study showed applying 2.5% arginine hydrochloride to atopic dermatitis skin showed significant urea levels in the stratum corneum and improved moisture in just four weeks.

Arginine is also a precursor to nitric oxide; nitric oxide improves microcirculation and supports wound healing and collagen synthesis.

One study found that an amino acid complex containing Arginine reduced skin irritation, improved hydration, and accelerated skin repair in clinical / in-vivo studies.

Arginine itself is an amino acid and not a fatty acid, oil, or ester. On its own, it's not a direct food source for Malassezia, or the yeast that causes fungal acne.

Beta-Glucan is a soluble polysaccharide (a chain of glucose sugars) sourced from the cells walls of oats, baker's yeast, mushrooms, and seaweed.

It's a rare ingredient that pulls double-duty as a heavy-duty hydrator and skin-soothing repair agent.

On the surface, it acts as a humectant that holds water in place and reduces moisture loss for a plumper, smoother feel, while its anti-inflammatory and antioxidant properties make it a great pick for calming redness or sensitive skin

The more interesting story is underneath:

Despite its large molecular size, oat beta-glucan has been shown to penetrate the epidermis and reach the dermis by slipping between skin cells. Here, it interacts with fibroblasts and macrophages to nudge collagen synthesis and support wound repair.

A small 2005 split-face clinical study of 27 subjects found topical beta-glucan produced measurable reductions in wrinkle depth, height, and roughness after 8 weeks of use.

It is worth noting the trial was small and the penetration testing used frozen, irradiated skin so the anti-aging data is encouraging rather than definitive.

This ingredient gets along with pretty much everything and is typically used around 0.1-1%.

Fungal acne: This ingredient is not a food source for the Malassezia yeast because it is a glucose polysaccharide with no fatty acid or ester component.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

We don't have a description for Calcium Alginate yet.

Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.

Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

We don't have a description for Caramel yet.

Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.

Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.

It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.

Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.

A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.

Dipotassium Glycyrrhizate comes from licorice root.

Extracts of licorice have demonstrated to have antibacterial, anti‐inflammatory, antiviral, antioxidant properties.

One component, glabridin, has extra potent antioxidant and soothing properties. It has also been found to block pigmentation from UVB rays in guinea pigs.

Licorice Root also contains a flavonoid. Flavonoids are a natural substance from in plants. Flavonoids also have antioxidant properties.

Another component, glycyrrhizin, has been found to have anti-inflammatory and antimicrobial benefits. This may make licorice root extract effective at treating acne. However, more research is needed to support this.

Liquiritin is one of the flavone compounds found in licorice. It has been found to help lighten skin by preventing tyrosinase from reacting with tyrosine. When the two react, protein is converted to melanin. Melanin is the substance in your body that gives your features pigmentation.

Licorice root is native to Southern Europe and Asia. It has been used in traditional Chinese medicine to help with respiratory issues.

Dipropylene Glycol is a synthetically created humectant, stabilizer, and solvent.

This ingredient helps:

Dipropylene glycol is technically an alcohol, but it belongs to the glycol family (often considered part of the ‘good’ alcohols). This means it is hydrating and gentle on skin unlike drying solvent alcohols like denatured alcohol.

As a masking agent, Dipropylene Glycol can be used to cover the smell of other ingredients. However, it does not have a scent.

Studies show Dipropylene Glycol is considered safe to use in skincare.

Gellan Gum is a high-molecular weight heteropolysaccharide gum. It is created by the process of pure-culture fermentation with the bacterium Pseudomonas elodea.

Gellan Gum is used to stabilize products. This helps improve the texture, consistency, and shelf life.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Glyceryl Acrylate/Acrylic Acid Copolymer is made up of glycerin and polyacrylic acid. It helps hydrate your skin as a humectant.

This ingredient forms a hydrogel that delivers moisturizing, water-based ingredients to the skin. It is also used to thicken a product and to give it a smooth texture.

Acrylic acid itself is toxic, but the polymer form (this ingredient) is too large to penetrate skin, making it non-toxic.

We don't have a description for Helichrysum Arenarium Extract yet.

Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.

And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.

You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.

In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.

If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.

When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.

When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.

In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).

Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.

Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.

The type of niacinamide used in skincare is synthetically created.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

Yeast extract is a silky, clear liquid derived from yeast (usually Saccharomyces cerevisiae or Torula yeast).

This ingredient has plenty of skin benefits:

Bioferments of yeast and soy have been found to reduce hyperpigmentation at low levels.

Yeast extract is fungal acne safe because it's made up of amino acids, peptides, B vitamins, and nucleotides (not the C11-C24 fatty acids that Malassezia needs to thrive).

The "yeast" in the name can be misleading, but FA safety is about chemical composition and not ingredient origin.

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