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Skinfix Triple-Lipid Peptide Lotion Versus SkinCeuticals Triple Lipid Restore 2:4:2

Skinfix Triple-Lipid Peptide Lotion Versus SkinCeuticals Triple Lipid Restore 2:4:2 This barrier-repair moisturizer is formulated around Caprylic/Capric Triglyceride and Jojoba Oil/Macadamia Seed Oil Esters to strengthen the skin barrier and hydrate skin. This

Written by Peptide Therapy Guide Editorial Team
For education only

This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.

Skinfix Triple-Lipid Peptide Lotion Versus SkinCeuticals Triple Lipid Restore 2:4:2

This barrier-repair moisturizer is formulated around Caprylic/Capric Triglyceride and Jojoba Oil/Macadamia Seed Oil Esters to strengthen the skin barrier and hydrate skin.

This barrier-repair moisturizer is formulated around Cholesterol and Ceramide NP to strengthen the skin barrier and soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Dicaprylyl Carbonate

Caprylic/Capric Triglyceride

Glycerin

Propanediol

Caprylyl Caprylate/Caprate

Jojoba Oil/Macadamia Seed Oil Esters

Behenyl Alcohol

Glyceryl Stearate

Butyrospermum Parkii Butter

Lecithin

Stearyl Alcohol

Nylon-11

Dicaprylyl Ether

Sodium Hyaluronate

Oryza Sativa Bran Extract

Glycine Soja Seed Extract

Squalene

Hydrolyzed Rice Protein

Hydrogenated Vegetable Oil

Glycine Soja Sterols

Phytosteryl Canola Glycerides

Chondrus Crispus Extract

Phytosteryl Macadamiate

Phytosterols

Aloe Barbadensis Leaf Juice

Rosmarinus Officinalis Leaf Extract

Helianthus Annuus Extract

Ethylhexylglycerin

Tocopherol

Dilinoleic Acid/Propanediol Copolymer

Pentylene Glycol

Trisodium Ethylenediamine Disuccinate

Gluconolactone

Sodium Benzoate

Xanthan Gum

Phenoxyethanol

Potassium Sorbate

Citric Acid

Water, Dicaprylyl Carbonate, Caprylic/Capric Triglyceride, Glycerin, Propanediol, Caprylyl Caprylate/Caprate, Jojoba Oil/Macadamia Seed Oil Esters, Behenyl Alcohol, Glyceryl Stearate, Butyrospermum Parkii Butter, Lecithin, Stearyl Alcohol, Nylon-11, Dicaprylyl Ether, Sodium Hyaluronate, Oryza Sativa Bran Extract, Glycine Soja Seed Extract, Squalene, Hydrolyzed Rice Protein, Hydrogenated Vegetable Oil, Glycine Soja Sterols, Phytosteryl Canola Glycerides, Chondrus Crispus Extract, Phytosteryl Macadamiate, Phytosterols, Aloe Barbadensis Leaf Juice, Rosmarinus Officinalis Leaf Extract, Helianthus Annuus Extract, Ethylhexylglycerin, Tocopherol, Dilinoleic Acid/Propanediol Copolymer, Pentylene Glycol, Trisodium Ethylenediamine Disuccinate, Gluconolactone, Sodium Benzoate, Xanthan Gum, Phenoxyethanol, Potassium Sorbate, Citric Acid

Dimethicone

Hydrogenated Polyisobutene

Cholesterol

C12-15 Alkyl Benzoate

Ceramide NP

Helianthus Annuus Seed Oil Unsaponifiables

Bis-PEG-18 Methyl Ether Dimethyl Silane

Sodium Polyacrylate

PEG-10 Dimethicone

Nylon-12

Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone

Dimethicone/PEG-10/15 Crosspolymer

Disteardimonium Hectorite

Hydroxyethylpiperazine Ethane Sulfonic Acid

Ammonium Polyacryloyldimethyl Taurate

Chlorphenesin

Caprylyl Glycol

PEG/PPG-18/18 Dimethicone

Propylene Carbonate

Disodium EDTA

Acrylonitrile/Methyl Methacrylate/Vinylidene Chloride Copolymer

Adenosine

Dipropylene Glycol

Lavandula Angustifolia Oil

Rosmarinus Officinalis Leaf Oil

T-Butyl Alcohol

Mentha Piperita Oil

Sodium Citrate

Linalool

Isobutane

Ceramide EOP

BHT

Limonene

Water, Dimethicone, Hydrogenated Polyisobutene, Glycerin, Cholesterol, C12-15 Alkyl Benzoate, Ceramide NP, Helianthus Annuus Seed Oil Unsaponifiables, Bis-PEG-18 Methyl Ether Dimethyl Silane, Sodium Polyacrylate, PEG-10 Dimethicone, Nylon-12, Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone, Dimethicone/PEG-10/15 Crosspolymer, Phenoxyethanol, Disteardimonium Hectorite, Hydroxyethylpiperazine Ethane Sulfonic Acid, Ammonium Polyacryloyldimethyl Taurate, Chlorphenesin, Caprylyl Glycol, PEG/PPG-18/18 Dimethicone, Propylene Carbonate, Disodium EDTA, Acrylonitrile/Methyl Methacrylate/Vinylidene Chloride Copolymer, Adenosine, Dipropylene Glycol, Lavandula Angustifolia Oil, Rosmarinus Officinalis Leaf Oil, T-Butyl Alcohol, Mentha Piperita Oil, Sodium Citrate, Linalool, Isobutane, Ceramide EOP, BHT, Tocopherol, Limonene

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Tocopherol is a fat-soluble antioxidant known as Vitamin E.

You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.

Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.

It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.

This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.

Concentrations usually range from 0.1-1% in most leave-on products.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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Peptide Therapy Guide Editorial Team

Editorial team for Peptide Therapy Guide.

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