Independent education resourceInformation here does not replace care from a qualified health professional.
Peptide Therapy GuideClear peptide education

Educational guide

Skinfix Triple-Lipid Peptide Lotion Versus Clinique Moisture Surge 100H Auto-Replenishing Hydrator

Skinfix Triple-Lipid Peptide Lotion Versus Clinique Moisture Surge 100H Auto-Replenishing Hydrator This barrier-repair moisturizer is formulated around Caprylic/Capric Triglyceride and Jojoba Oil/Macadamia Seed Oil Esters to strengthen the skin barrier and hyd

Written by Peptide Therapy Guide Editorial Team
For education only

This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.

Skinfix Triple-Lipid Peptide Lotion Versus Clinique Moisture Surge 100H Auto-Replenishing Hydrator

This barrier-repair moisturizer is formulated around Caprylic/Capric Triglyceride and Jojoba Oil/Macadamia Seed Oil Esters to strengthen the skin barrier and hydrate skin.

This barrier-repair moisturizer is formulated around Sodium Hyaluronate and Aloe Barbadensis Leaf Extract to strengthen the skin barrier and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Dicaprylyl Carbonate

Caprylic/Capric Triglyceride

Glycerin

Propanediol

Caprylyl Caprylate/Caprate

Jojoba Oil/Macadamia Seed Oil Esters

Behenyl Alcohol

Glyceryl Stearate

Butyrospermum Parkii Butter

Lecithin

Stearyl Alcohol

Nylon-11

Dicaprylyl Ether

Sodium Hyaluronate

Oryza Sativa Bran Extract

Glycine Soja Seed Extract

Squalene

Hydrolyzed Rice Protein

Hydrogenated Vegetable Oil

Glycine Soja Sterols

Phytosteryl Canola Glycerides

Chondrus Crispus Extract

Phytosteryl Macadamiate

Phytosterols

Aloe Barbadensis Leaf Juice

Rosmarinus Officinalis Leaf Extract

Helianthus Annuus Extract

Ethylhexylglycerin

Tocopherol

Dilinoleic Acid/Propanediol Copolymer

Pentylene Glycol

Trisodium Ethylenediamine Disuccinate

Gluconolactone

Sodium Benzoate

Xanthan Gum

Phenoxyethanol

Potassium Sorbate

Citric Acid

Water, Dicaprylyl Carbonate, Caprylic/Capric Triglyceride, Glycerin, Propanediol, Caprylyl Caprylate/Caprate, Jojoba Oil/Macadamia Seed Oil Esters, Behenyl Alcohol, Glyceryl Stearate, Butyrospermum Parkii Butter, Lecithin, Stearyl Alcohol, Nylon-11, Dicaprylyl Ether, Sodium Hyaluronate, Oryza Sativa Bran Extract, Glycine Soja Seed Extract, Squalene, Hydrolyzed Rice Protein, Hydrogenated Vegetable Oil, Glycine Soja Sterols, Phytosteryl Canola Glycerides, Chondrus Crispus Extract, Phytosteryl Macadamiate, Phytosterols, Aloe Barbadensis Leaf Juice, Rosmarinus Officinalis Leaf Extract, Helianthus Annuus Extract, Ethylhexylglycerin, Tocopherol, Dilinoleic Acid/Propanediol Copolymer, Pentylene Glycol, Trisodium Ethylenediamine Disuccinate, Gluconolactone, Sodium Benzoate, Xanthan Gum, Phenoxyethanol, Potassium Sorbate, Citric Acid

Dimethicone

Butylene Glycol

Trisiloxane

Trehalose

Saccharomyces Lysate Extract

Aloe Barbadensis Leaf Extract

Aloe Barbadensis Leaf Water

Silybum Marianum Extract

Camellia Sinensis Leaf Extract

Aloe Barbadensis Leaf Polysaccharides

Sorbitol

Sodium Polyaspartate

Caffeine

Thermus Thermophillus Ferment

Lactobacillus Ferment Lysate

Palmitoyl Hexapeptide-12

Caprylyl Glycol

Sucrose

Hydroxyethyl Urea

Ammonium Acryloyldimethyltaurate/Vp Copolymer

Oleth-10

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Saccharide Isomerate

Hydrogenated Lecithin

Tromethamine

Glyceryl Polymethacrylate

Disodium EDTA

PEG-8

Hexylene Glycol

Sodium Citrate

Tocopheryl Acetate

BHT

Magnesium Ascorbyl Phosphate

CI 14700

CI 19140

Water, Dimethicone, Butylene Glycol, Glycerin, Trisiloxane, Trehalose, Saccharomyces Lysate Extract, Sodium Hyaluronate, Aloe Barbadensis Leaf Extract, Aloe Barbadensis Leaf Water, Silybum Marianum Extract, Camellia Sinensis Leaf Extract, Aloe Barbadensis Leaf Polysaccharides, Sorbitol, Sodium Polyaspartate, Caffeine, Thermus Thermophillus Ferment, Lactobacillus Ferment Lysate, Palmitoyl Hexapeptide-12, Caprylyl Glycol, Sucrose, Hydroxyethyl Urea, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Oleth-10, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Saccharide Isomerate, Hydrogenated Lecithin, Tromethamine, Glyceryl Polymethacrylate, Disodium EDTA, PEG-8, Hexylene Glycol, Citric Acid, Sodium Citrate, Tocopheryl Acetate, BHT, Magnesium Ascorbyl Phosphate, Phenoxyethanol, Sodium Benzoate, Potassium Sorbate, CI 14700, CI 19140

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Citric Acid is an alpha hydroxy acid (AHA) naturally found in citrus fruits like oranges, lemons, and limes.

Like other AHAs, citric acid can exfoliate skin by breaking down the bonds that hold dead skin cells together. This helps reveal smoother and brighter skin underneath.

However, this exfoliating effect only happens at high concentrations (20%) which can be hard to find in cosmetic products.

Due to this, citric acid is usually included in small amounts as a pH adjuster. This helps keep products slightly more acidic and compatible with skin's natural pH.

In skincare formulas, citric acid can:

While it can provide some skin benefits, research shows lactic acid and glycolic acid are generally more effective and less irritating exfoliants.

Most citric acid used in skincare today is made by fermenting sugars (usually from molasses). This synthetic version is identical to the natural citrus form but easier to stabilize and use in formulations.

Rosacea skin has a lower threshold for acids generally, with 62.5% of rosacea subjects in one study reacting to lactic acid in a sting test. This is why we mark citric acid as a potential rosacea trigger.

However, this ingredient shows up as a pH adjuster or chelator at roughly 0.1-1% in many products. These low levels are unlikely to be an issue for rosacea skin and becomes a potential trigger at exfoliating concentrations (20%). Because everybody's skin is unique, we recommend a patch test if you are unsure.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Potassium Sorbate is a preservative used to prevent yeast and mold in products. It is commonly found in both cosmetic and food products.

This ingredient comes from potassium salt derived from sorbic acid. Sorbic acid is a natural antibiotic and effective against fungus.

Both potassium sorbate and sorbic acid can be found in baked goods, cheeses, dried meats, dried fruit, ice cream, pickles, wine, yogurt, and more.

You'll often find this ingredient used with other preservatives.

Sodium Benzoate is a preservative. It's used in both cosmetic and food products to inhibit the growth of mold and bacteria. It is typically produced synthetically.

Both the US FDA and EU Health Committee have approved the use of sodium benzoate. In the US, levels of 0.1% (of the total product) are allowed.

Sodium benzoate works as a preservative by inhibiting the growth of bacteria inside of cells. It prevents the cell from fermenting a type of sugar using an enzyme called phosphofructokinase.

It is the salt of benzoic acid. Foods containing sodium benzoate include soda, salad dressings, condiments, fruit juices, wines, and snack foods.

Studies for using ascorbic acid and sodium benzoate in cosmetics are lacking, especially in skincare routines with multiple steps.

We always recommend speaking with a professional, such as a dermatologist, if you have any concerns.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

Connected reading

Helpful context for this guide

Source-derived material selected through this article’s indexed topics.

P

About the author

Peptide Therapy Guide Editorial Team

Editorial team for Peptide Therapy Guide.

View all articles →