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SkinCeuticals Resveratrol B E Versus Estée Lauder Advanced Night Repair Intense Reset Concentrate

SkinCeuticals Resveratrol B E Versus Estée Lauder Advanced Night Repair Intense Reset Concentrate This anti-aging serum is formulated around Niacinamide and Resveratrol to soften the look of wrinkles and brighten dull-looking skin. This calming serum is formul

Written by Peptide Therapy Guide Editorial Team
For education only

This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.

SkinCeuticals Resveratrol B E Versus Estée Lauder Advanced Night Repair Intense Reset Concentrate

This anti-aging serum is formulated around Niacinamide and Resveratrol to soften the look of wrinkles and brighten dull-looking skin.

This calming serum is formulated around Lactobacillus Ferment and Resveratrol to calm redness and strengthen the skin barrier.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Dimethicone

Propylene Glycol

Dipropylene Glycol

Niacinamide

Alcohol Denat.

Glycerin

Caffeine

Sodium Chloride

PEG/PPG-18/18 Dimethicone

Tocopherol

Resveratrol

Scutellaria Baicalensis Extract

Scutellaria Baicalensis Root Extract

Disodium EDTA

Water, Dimethicone, Propylene Glycol, Dipropylene Glycol, Niacinamide, Alcohol Denat., Glycerin, Caffeine, Sodium Chloride, PEG/PPG-18/18 Dimethicone, Tocopherol, Resveratrol, Scutellaria Baicalensis Extract, Scutellaria Baicalensis Root Extract, Disodium EDTA

Methyl Trimethicone

Bis-PEG-18 Methyl Ether Dimethyl Silane

Butylene Glycol

Isopropyl Isostearate

PPG-15 Stearyl Ether

PEG-10 Dimethicone

Faex Extract

Tripeptide-32

Sodium Hyaluronate Crosspolymer

Sodium Hyaluronate

Hydrolyzed Sodium Hyaluronate

Hydrolyzed Algin

Lactobacillus Ferment

Adansonia Digitata Seed Extract

Soy Amino Acids

Aminopropyl Ascorbyl Phosphate

Algae Extract

Salicylic Acid

Ergothioneine

Tocopheryl Acetate

Whey Protein

Avena Sativa Kernel Extract

Citrullus Lanatus Fruit Extract

Laminaria Digitata Extract

Lens Esculenta Fruit Extract

Pyrus Malus Fruit Extract

Sodium PCA

Propylene Glycol Caprylate

Triticum Vulgare Germ Extract

Lavandula Angustifolia Oil

Hordeum Vulgare Extract

Anthemis Nobilis Flower Extract

Isohexadecane

Polysilicone-11

Methyldihydrojasmonate

Sodium Lactate

Disteardimonium Hectorite

Isododecane

Polyacrylate Crosspolymer-6

Squalane

Polyethylene

Propylene Carbonate

Pentylene Glycol

BHT

Potassium Sorbate

Sodium Benzoate

Phenoxyethanol

Linalool

CI 14700

CI 19140

Water, Dimethicone, Glycerin, Methyl Trimethicone, Bis-PEG-18 Methyl Ether Dimethyl Silane, Butylene Glycol, Isopropyl Isostearate, PPG-15 Stearyl Ether, PEG-10 Dimethicone, Faex Extract, Tripeptide-32, Sodium Hyaluronate Crosspolymer, Sodium Hyaluronate, Hydrolyzed Sodium Hyaluronate, Hydrolyzed Algin, Lactobacillus Ferment, Adansonia Digitata Seed Extract, Soy Amino Acids, Aminopropyl Ascorbyl Phosphate, Resveratrol, Algae Extract, Salicylic Acid, Ergothioneine, Tocopheryl Acetate, Whey Protein, Avena Sativa Kernel Extract, Citrullus Lanatus Fruit Extract, Laminaria Digitata Extract, Lens Esculenta Fruit Extract, Pyrus Malus Fruit Extract, Caffeine, Sodium PCA, Propylene Glycol Caprylate, Triticum Vulgare Germ Extract, Lavandula Angustifolia Oil, Hordeum Vulgare Extract, Anthemis Nobilis Flower Extract, Isohexadecane, Polysilicone-11, Methyldihydrojasmonate, Sodium Lactate, Disteardimonium Hectorite, Isododecane, Polyacrylate Crosspolymer-6, Squalane, Polyethylene, Propylene Carbonate, Pentylene Glycol, Disodium EDTA, BHT, Potassium Sorbate, Sodium Benzoate, Phenoxyethanol, Linalool, CI 14700, CI 19140

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Caffeine is a naturally occurring plant compound found in coffee beans, tea leaves, cocoa pods, and guarana.

As an antioxidant, caffeine protects your skin from free radical damage caused by UV exposure and envionrmnetal stressors.

Early research also shows that caffeine can help calm redness, soothe irritated skin, and support hair growth by stimulating microcirculation in the scalp.

You might have seen eye creams marketing caffeine as a depuffing ingredient. This is because it is a vasoconstrictor meaning it can temporarily constrict blood vessels, though clinical evidence for this specific use is still limited.

Most skincare products contain this ingredient at concentrations between 1-6%. It is able to penetrate skin easily regardless of skin type or thickness.

Just so you know, a very small number of case reports describe caffeine-induced allergy. This ingredient is generally well-tolerated, non-irritating, and non-sensitizing for the majority of people.

Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.

What it does:

Dimethicone comes in different viscosities:

Depending on the viscosity, dimethicone has different properties.

Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.

This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.

Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.

Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.

This ingredient mainly works behind the scenes and helps with:

On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.

One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).

Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.

You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Resveratrol is a well-studied polyphenol antioxidant that has gained attention in skincare for its protective and calming effects on the skin. It’s often considered a gentler option for people who can’t tolerate retinoids.

This antioxidant is best known for its anti-aging benefits. Research suggests resveratrol helps combat visible signs of aging by:

Beyond anti-aging, resveratrol is also valued for its skin-brightening and soothing properties.

Some forms of resveratrol appear to be more effective than others. Resveratrol isobutyrate and resveratrol butyrate are often cited as more stable derivatives.

Research also suggests these two forms have stronger effects on Type I collagen stimulation and inflammation reduction compared to basic resveratrol.

Resveratrol is naturally unstable and can degrade when exposed to light and oxygen. Well-designed products often use stabilized derivatives, airless or opaque packaging, and supporting antioxidants to help maintain effectiveness on skin.

A note on resveratrol as a retinoid alternative: While resveratrol offers antioxidant protection, inflammation control, and some collagen-supporting benefits, it does not replace retinoids in terms of cell turnover or acne treatment.

However, it can be a useful option for people with retinoid sensitivity or intolerance, or for those looking to support skin health without irritation.

Fun fact: Resveratrol is naturally found in grapes, peanuts, and berries, which is why it’s frequently associated with wine and grape-derived skincare ingredients.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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Peptide Therapy Guide Editorial Team

Editorial team for Peptide Therapy Guide.

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