Educational guide
Sisley Paris Supremÿa at Night Supreme Anti-Aging Eye Serum Versus Estée Lauder Advanced Night Repair Synchronized Multi-Recovery Complex Serum
Sisley Paris Supremÿa at Night Supreme Anti-Aging Eye Serum Versus Estée Lauder Advanced Night Repair Synchronized Multi-Recovery Complex Serum This anti-aging eye moisturizer is formulated around Caffeine and Adenosine to soften the look of wrinkles and fade
This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.
Sisley Paris Supremÿa at Night Supreme Anti-Aging Eye Serum Versus Estée Lauder Advanced Night Repair Synchronized Multi-Recovery Complex Serum
This anti-aging eye moisturizer is formulated around Caffeine and Adenosine to soften the look of wrinkles and fade the look of dark spots.
This barrier-repair serum is formulated around Bifida Ferment Lysate and Sodium Hyaluronate to strengthen the skin barrier and soften the look of wrinkles.
What's inside
Key Ingredients
Benefits
Concerns
Ingredients Side-by-side
Water
Glycerin
Butylene Glycol
Prunus Domestica Seed Extract
Butyrospermum Parkii Butter
Propylheptyl Caprylate
Sodium Acrylates Copolymer
Caprylyl Methicone
Glyceryl Stearate Citrate
Pvp
Caffeine
Bisabolol
Saccharomyces Cerevisiae Extract
Avena Sativa Kernel Extract
Hydrolyzed Soy Protein
Salix Alba Leaf Extract
Adenosine
Physalis Alkekengi Calyx Extract
Euterpe Oleracea Fruit Extract
Padina Pavonica Thallus Extract
Hydrolyzed Triticum Monococcum Seed Extract
Oryza Sativa Extract
Simmondsia Chinensis Seed Oil
Hydrogenated Polyisobutene
Sodium Acryloyldimethyltaurate/Vp Crosspolymer
Phospholipids
Polyglyceryl-10 Stearate
Helianthus Annuus Seed Oil
Disodium EDTA
Pentylene Glycol
PPG-26-Buteth-26
Xanthan Gum
PEG-40 Hydrogenated Castor Oil
Sodium Hydroxide
Ethylhexylglycerin
Citric Acid
Phenoxyethanol
Sorbic Acid
Sodium Benzoate
Potassium Sorbate
Tocopherol
Water, Glycerin, Butylene Glycol, Prunus Domestica Seed Extract, Butyrospermum Parkii Butter, Propylheptyl Caprylate, Sodium Acrylates Copolymer, Caprylyl Methicone, Glyceryl Stearate Citrate, Pvp, Caffeine, Bisabolol, Saccharomyces Cerevisiae Extract, Avena Sativa Kernel Extract, Hydrolyzed Soy Protein, Salix Alba Leaf Extract, Adenosine, Physalis Alkekengi Calyx Extract, Euterpe Oleracea Fruit Extract, Padina Pavonica Thallus Extract, Hydrolyzed Triticum Monococcum Seed Extract, Oryza Sativa Extract, Simmondsia Chinensis Seed Oil, Hydrogenated Polyisobutene, Sodium Acryloyldimethyltaurate/Vp Crosspolymer, Phospholipids, Polyglyceryl-10 Stearate, Helianthus Annuus Seed Oil, Disodium EDTA, Pentylene Glycol, PPG-26-Buteth-26, Xanthan Gum, PEG-40 Hydrogenated Castor Oil, Sodium Hydroxide, Ethylhexylglycerin, Citric Acid, Phenoxyethanol, Sorbic Acid, Sodium Benzoate, Potassium Sorbate, Tocopherol
Bifida Ferment Lysate
PEG-8
Propanediol
Bis-PEG-18 Methyl Ether Dimethyl Silane
Methyl Gluceth-20
Glycereth-26
PEG-75
Adansonia Digitata Seed Extract
Tripeptide-32
Sodium Hyaluronate
Faex Extract
Lactobacillus Ferment
Cola Acuminata Seed Extract
Anthemis Nobilis Flower Extract
Hydrolyzed Algin
Pantethine
Lecithin
Sodium Rna
Squalane
Oleth-3 Phosphate
Caprylyl Glycol
Oleth-3
Oleth-5
Choleth-24
Hydrogenated Lecithin
Jojoba Wax PEG-120 Esters
Ceteth-24
Tocopheryl Acetate
Carbomer
Triethanolamine
Tetrasodium EDTA
BHT
CI 14700
CI 19140
Water, Bifida Ferment Lysate, PEG-8, Propanediol, Bis-PEG-18 Methyl Ether Dimethyl Silane, Methyl Gluceth-20, Glycereth-26, PEG-75, Butylene Glycol, Adansonia Digitata Seed Extract, Tripeptide-32, Sodium Hyaluronate, Faex Extract, Lactobacillus Ferment, Cola Acuminata Seed Extract, Anthemis Nobilis Flower Extract, Hydrolyzed Algin, Pantethine, Caffeine, Lecithin, Sodium Rna, Bisabolol, Squalane, Glycerin, Oleth-3 Phosphate, Caprylyl Glycol, Oleth-3, Oleth-5, Choleth-24, Hydrogenated Lecithin, Jojoba Wax PEG-120 Esters, Ceteth-24, Tocopheryl Acetate, Carbomer, Triethanolamine, Tetrasodium EDTA, BHT, Xanthan Gum, Potassium Sorbate, Disodium EDTA, Phenoxyethanol, CI 14700, CI 19140
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Alternatives
Ingredients Explained
These ingredients are found in both products.
Ingredients higher up in an ingredient list are typically present in a larger amount.
Bisabolol is a gentle skin conditioner, antioxidant, and soothing ingredient.
It's primary claim to fame is soothing and research shows topically applied bisabolol can quiet the chemical messengers that cause your skin to become inflamed, helping to sooth any irritation.
A clinical study found that applying 0.5% bisabolol daily for 8 weeks produced an average 9% decrease in skin pigmentation. Researchers found it can also suppress the process that leads to excess melanin production in skin.
In vitro studies found that bisabolol combined with propylene glycol significantly increased skin permeability by increasing lipid fluidity in the stratum corneum.
You'll likely see use concentrations quite low, usually 0.1-0.2%.
Overall, this is a well-tolerated ingredient that works well in formulas designed for sensitive, reactive, or post-procedure skin.
Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:
Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.
Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.
Caffeine is a naturally occurring plant compound found in coffee beans, tea leaves, cocoa pods, and guarana.
As an antioxidant, caffeine protects your skin from free radical damage caused by UV exposure and envionrmnetal stressors.
Early research also shows that caffeine can help calm redness, soothe irritated skin, and support hair growth by stimulating microcirculation in the scalp.
You might have seen eye creams marketing caffeine as a depuffing ingredient. This is because it is a vasoconstrictor meaning it can temporarily constrict blood vessels, though clinical evidence for this specific use is still limited.
Most skincare products contain this ingredient at concentrations between 1-6%. It is able to penetrate skin easily regardless of skin type or thickness.
Just so you know, a very small number of case reports describe caffeine-induced allergy. This ingredient is generally well-tolerated, non-irritating, and non-sensitizing for the majority of people.
Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.
This ingredient mainly works behind the scenes and helps with:
On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.
One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).
Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.
You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.
Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.
Topically, glycerin does several things at once:
Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.
Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.
This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.
Just know very high concentrations (>40%) can feel tacky in low humidity.
Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.
Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).
It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.
On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.
Another perk of this ingredient is that it stays functional across a wide pH range (3-10).
You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.
Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.
Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.
Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.
Potassium Sorbate is a preservative used to prevent yeast and mold in products. It is commonly found in both cosmetic and food products.
This ingredient comes from potassium salt derived from sorbic acid. Sorbic acid is a natural antibiotic and effective against fungus.
Both potassium sorbate and sorbic acid can be found in baked goods, cheeses, dried meats, dried fruit, ice cream, pickles, wine, yogurt, and more.
You'll often find this ingredient used with other preservatives.
Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.
So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.
You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!
Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.
On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.
Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.