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Peter Thomas Roth Water Drench Hyaluronic Cloud Cream Hydrating Moisturizer Versus Biossance Squalane + Probiotic Gel Moisturizer

Peter Thomas Roth Water Drench Hyaluronic Cloud Cream Hydrating Moisturizer Versus Biossance Squalane + Probiotic Gel Moisturizer This barrier-repair moisturizer is formulated around Sodium Hyaluronate and Ceramide NP to strengthen the skin barrier and hydrate

Written by Peptide Therapy Guide Editorial Team
For education only

This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.

Peter Thomas Roth Water Drench Hyaluronic Cloud Cream Hydrating Moisturizer Versus Biossance Squalane + Probiotic Gel Moisturizer

This barrier-repair moisturizer is formulated around Sodium Hyaluronate and Ceramide NP to strengthen the skin barrier and hydrate skin.

This barrier-repair moisturizer is formulated around Squalane to strengthen the skin barrier and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Cyclopentasiloxane

Dipropylene Glycol

Dimethicone

Cyclohexasiloxane

Yeast Extract

Sodium Hyaluronate

Ceramide EOP

Ceramide Eos

Ceramide AP

Ceramide NP

Ceramide Ns

Sambucus Nigra Fruit Extract

Hydrolyzed Silk

Sodium PCA

Tocopherol

Ascorbyl Palmitate

Caprooyl Phytosphingosine

Caprooyl Sphingosine

Saccharide Isomerate

Saccharomyces/Magnesium Ferment

Saccharomyces/Iron Ferment

Saccharomyces/Copper Ferment

Saccharomyces/Silicon Ferment

Saccharomyces/Zinc Ferment

Olea Europaea Leaf Extract

Methyl Gluceth-20

Ethylhexylglycerin

Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone

Cholesterol

Sodium Chloride

Sodium Citrate

Citric Acid

Behenic Acid

Propylene Glycol

Ceteareth-25

Butylene Glycol

Dimethicone/PEG-10/15 Crosspolymer

Cetyl Alcohol

Disodium EDTA

Sodium Benzoate

Potassium Sorbate

Phenoxyethanol

Mica

Water, Glycerin, Cyclopentasiloxane, Dipropylene Glycol, Dimethicone, Cyclohexasiloxane, Yeast Extract, Sodium Hyaluronate, Ceramide EOP, Ceramide Eos, Ceramide AP, Ceramide NP, Ceramide Ns, Sambucus Nigra Fruit Extract, Hydrolyzed Silk, Sodium PCA, Tocopherol, Ascorbyl Palmitate, Caprooyl Phytosphingosine, Caprooyl Sphingosine, Saccharide Isomerate, Saccharomyces/Magnesium Ferment, Saccharomyces/Iron Ferment, Saccharomyces/Copper Ferment, Saccharomyces/Silicon Ferment, Saccharomyces/Zinc Ferment, Olea Europaea Leaf Extract, Methyl Gluceth-20, Ethylhexylglycerin, Lauryl PEG-9 Polydimethylsiloxyethyl Dimethicone, Cholesterol, Sodium Chloride, Sodium Citrate, Citric Acid, Behenic Acid, Propylene Glycol, Ceteareth-25, Butylene Glycol, Dimethicone/PEG-10/15 Crosspolymer, Cetyl Alcohol, Disodium EDTA, Sodium Benzoate, Potassium Sorbate, Phenoxyethanol, Mica

Squalane

Lepidium Sativum Sprout Extract

Sodium Acrylates Copolymer

Caprylic/Capric Triglyceride

Capryloyl Glycerin/Sebacic Acid Copolymer

Lecithin

Caprylyl Glycol

Diheptyl Succinate

Isoeicosane

Allantoin

Bisabolol

Sodium Phytate

Glycine Soja Sterols

Linoleic Acid

Phospholipids

Hansenula/Kloeckera/Lactobacillus/Lactococcus/Leuconostoc/Pediococcus/Saccharomyces/Fig/Lemon Ferment

Chondrus Crispus Extract

Sorbitan Oleate

Cellulose Gum

Chitosan

1,2-Hexanediol

Water, Glycerin, Squalane, Lepidium Sativum Sprout Extract, Sodium Acrylates Copolymer, Caprylic/Capric Triglyceride, Phenoxyethanol, Capryloyl Glycerin/Sebacic Acid Copolymer, Lecithin, Caprylyl Glycol, Diheptyl Succinate, Isoeicosane, Allantoin, Bisabolol, Sodium Phytate, Glycine Soja Sterols, Linoleic Acid, Phospholipids, Hansenula/Kloeckera/Lactobacillus/Lactococcus/Leuconostoc/Pediococcus/Saccharomyces/Fig/Lemon Ferment, Chondrus Crispus Extract, Sorbitan Oleate, Cellulose Gum, Chitosan, 1,2-Hexanediol, Sodium Hyaluronate, Citric Acid, Potassium Sorbate

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Citric Acid is an alpha hydroxy acid (AHA) naturally found in citrus fruits like oranges, lemons, and limes.

Like other AHAs, citric acid can exfoliate skin by breaking down the bonds that hold dead skin cells together. This helps reveal smoother and brighter skin underneath.

However, this exfoliating effect only happens at high concentrations (20%) which can be hard to find in cosmetic products.

Due to this, citric acid is usually included in small amounts as a pH adjuster. This helps keep products slightly more acidic and compatible with skin's natural pH.

In skincare formulas, citric acid can:

While it can provide some skin benefits, research shows lactic acid and glycolic acid are generally more effective and less irritating exfoliants.

Most citric acid used in skincare today is made by fermenting sugars (usually from molasses). This synthetic version is identical to the natural citrus form but easier to stabilize and use in formulations.

Rosacea skin has a lower threshold for acids generally, with 62.5% of rosacea subjects in one study reacting to lactic acid in a sting test. This is why we mark citric acid as a potential rosacea trigger.

However, this ingredient shows up as a pH adjuster or chelator at roughly 0.1-1% in many products. These low levels are unlikely to be an issue for rosacea skin and becomes a potential trigger at exfoliating concentrations (20%). Because everybody's skin is unique, we recommend a patch test if you are unsure.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Potassium Sorbate is a preservative used to prevent yeast and mold in products. It is commonly found in both cosmetic and food products.

This ingredient comes from potassium salt derived from sorbic acid. Sorbic acid is a natural antibiotic and effective against fungus.

Both potassium sorbate and sorbic acid can be found in baked goods, cheeses, dried meats, dried fruit, ice cream, pickles, wine, yogurt, and more.

You'll often find this ingredient used with other preservatives.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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About the author

Peptide Therapy Guide Editorial Team

Editorial team for Peptide Therapy Guide.

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