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No7 Early Defence Day Cream Versus Biossance Squalane + Omega Repair Cream

No7 Early Defence Day Cream Versus Biossance Squalane + Omega Repair Cream This anti-aging day moisturizer is formulated around Ascorbyl Glucoside and Retinyl Palmitate to soften the look of wrinkles and brighten dull-looking skin. This barrier-repair moisturi

Written by Peptide Therapy Guide Editorial Team
For education only

This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.

No7 Early Defence Day Cream Versus Biossance Squalane + Omega Repair Cream

This anti-aging day moisturizer is formulated around Ascorbyl Glucoside and Retinyl Palmitate to soften the look of wrinkles and brighten dull-looking skin.

This barrier-repair moisturizer is formulated around Squalane and Ceramide NP to strengthen the skin barrier and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

C12-15 Alkyl Benzoate

Octocrylene

Butyl Methoxydibenzoylmethane

Cetearyl Glucoside

Dimethicone

Aluminum Starch Octenylsuccinate

Ethylhexyl Salicylate

Alcohol Denat.

Ammonium Acryloyldimethyltaurate/Vp Copolymer

Phenoxyethanol

Butyrospermum Parkii Butter

Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine

Potassium Cetyl Phosphate

Methylparaben

Parfum

Butylene Glycol

Dimethiconol

Propylene Glycol

Xanthan Gum

Tocopheryl Acetate

Ethylparaben

Diethylhexyl Butamido Triazone

Ascorbyl Glucoside

Retinyl Palmitate

Hydrolyzed Rice Protein

Tetrasodium EDTA

T-Butyl Alcohol

Panax Ginseng Root Extract

Dimethylmethoxy Chromanol

Medicago Sativa Extract

Potassium Hydroxide

Carbomer

Polysorbate 20

Morus Alba Leaf Extract

Silica

Isopropyl Myristate

Sodium Benzoate

Tocopherol

Ethylhexylglycerin

Palmitoyl Tripeptide-1

Palmitoyl Tetrapeptide-7

Water, Glycerin, C12-15 Alkyl Benzoate, Octocrylene, Butyl Methoxydibenzoylmethane, Cetearyl Glucoside, Dimethicone, Aluminum Starch Octenylsuccinate, Ethylhexyl Salicylate, Alcohol Denat., Ammonium Acryloyldimethyltaurate/Vp Copolymer, Phenoxyethanol, Butyrospermum Parkii Butter, Bis-Ethylhexyloxyphenol Methoxyphenyl Triazine, Potassium Cetyl Phosphate, Methylparaben, Parfum, Butylene Glycol, Dimethiconol, Propylene Glycol, Xanthan Gum, Tocopheryl Acetate, Ethylparaben, Diethylhexyl Butamido Triazone, Ascorbyl Glucoside, Retinyl Palmitate, Hydrolyzed Rice Protein, Tetrasodium EDTA, T-Butyl Alcohol, Panax Ginseng Root Extract, Dimethylmethoxy Chromanol, Medicago Sativa Extract, Potassium Hydroxide, Carbomer, Polysorbate 20, Morus Alba Leaf Extract, Silica, Isopropyl Myristate, Sodium Benzoate, Tocopherol, Ethylhexylglycerin, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7

Squalane

Caprylic/Capric Triglyceride

Isoamyl Laurate

Sorbitan Olivate

Cetearyl Olivate

Ceramide NP

Jojoba Esters

Sodium Hyaluronate

Euterpe Oleracea Sterols

Linoleic Acid

Oleic Acid

Linolenic Acid

Ethyl Linoleate

Isoamyl Cocoate

Cetyl Palmitate

Sorbitan Palmitate

Cetearyl Alcohol

Sodium Hydroxide

Sodium Gluconate

Water, Squalane, Glycerin, Caprylic/Capric Triglyceride, Isoamyl Laurate, Butyrospermum Parkii Butter, Sorbitan Olivate, Cetearyl Olivate, Ceramide NP, Jojoba Esters, Sodium Hyaluronate, Euterpe Oleracea Sterols, Linoleic Acid, Oleic Acid, Linolenic Acid, Ethyl Linoleate, Tocopherol, Isoamyl Cocoate, Cetyl Palmitate, Sorbitan Palmitate, Cetearyl Alcohol, Ethylhexylglycerin, Carbomer, Sodium Hydroxide, Phenoxyethanol, Sodium Gluconate

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

This ingredient is also known as shea butter. It is a plant-derived extract from the nuts of the Africa shea tree and one of the most well-studied emollients.

Because it has a high concentration of fatty acids (primarily oleic, stearic, and linoleic) it is able to form a protective barrier on the skin's surface. This helps seal in moisture and prevents transepidermal water loss (TEWL).

In vitro research found an increase in skin hydration by 58% and a decrease in TEWL by 37.8% after 24 hours of applying this ingredient (pretty impressive for a single ingredient!).

Besides hydration, shea butter also contains triterpenes that have anti-inflammatory potential. In particule, lupeol cinnamate has shown the highest anti-inflammatory activity in vivo.

Shea butter also contains vitamins A and E which may contribute to antioxidant activity.

While Shea Butter has an SPF rating of about 3-4, it is not a sunscreen replacement.

This ingredient may not be fungal acne safe because its fatty acids fall within the C11-C24 range that the Malassezia yeast can metabolize.

Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.

Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.

It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.

Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.

A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Tocopherol is a fat-soluble antioxidant known as Vitamin E.

You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.

Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.

It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.

This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.

Concentrations usually range from 0.1-1% in most leave-on products.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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About the author

Peptide Therapy Guide Editorial Team

Editorial team for Peptide Therapy Guide.

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