Educational guide
PepMix™ Peptide Pools Advancing TCR-T Cancer Research
TCR-T Research with PepMix™ Peptide Pools for Key Cancer Targets Published on 15/05/2025 T-cell receptor-engineered T-cell therapy (TCR-T) is rapidly gaining momentum in the field of cancer immunotherapy. Unlike CAR-T cells, which recognize surface antigens, T
This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.
TCR-T Research with PepMix™ Peptide Pools for Key Cancer Targets
Published on 15/05/2025
T-cell receptor-engineered T-cell therapy (TCR-T) is rapidly gaining momentum in the field of cancer immunotherapy. Unlike CAR-T cells, which recognize surface antigens, TCR-T cells can detect and eliminate cancer cells based on intracellular tumor-associated antigens presented by MHC molecules, offering broader therapeutic opportunities across solid and hematologic malignancies.
A recent comprehensive review (Zhang et al., 2023) highlights the 16 major cancer targets currently pursued in TCR-T clinical trials. JPT is proud to support researchers in this exciting field by offering PepMix™ Peptide Pools for 15 of these 16 critical targets — and a partial PepMix™ for the remaining one (EGFRvIII).
Main TCR-T Targets Available as PepMix™ Peptide Pools:
AFP (Alpha-fetoprotein)
EGFRvIII (partially available as ErbB2-ICD and ErbB2-ECD)
EBV (Epstein-Barr Virus)
HA-1
HBV (Hepatitis B Virus)
HPV (Human Papillomavirus)
KK-LC-1
KRAS (mutated)
MAGE-A1
MAGE-A3
MAGE-A4
MAGE-A10
MART-1
Mesothelin
NY-ESO-1
WT1
Check all our tumor-associated antigen peptide pools and our more than 1500 individual epitope peptides.
Why Choose PepMix™ Peptide Pools for TCR-T Research?
Comprehensive Antigen Coverage: Each PepMix™ consists of overlapping peptides that span the full protein sequence, ensuring maximal coverage of known and novel epitopes — ideal for discovery, monitoring, and functional assays.
High Quality and Batch Consistency: Our optimized synthesis and stringent QC processes guarantee high purity, reproducibility, and biological performance you can trust for clinical research.
Experience with Difficult Sequences: Hydrophobic and aggregation-prone sequences? No problem. JPT’s proven expertise ensures even challenging targets are fully represented in your peptide pool.
Immediate Availability: More than 450 different catalog PepMix™ peptide pools are available from stock — enabling faster project initiation and smoother workflows. In case we do not have you antigen, contact us! We can provide it to you as a custom PepMix™ Peptide Pool.
Accelerate Your TCR-T Research
PepMix™ Peptide Pools are widely used for:
Screening TCRs for target specificity
Monitoring T-cell responses post-infusion
Identifying immunodominant epitopes
Supporting preclinical and translational studies
Advance your TCR-T programs with reliable tools trusted by researchers worldwide and learn more about The World of PepMix™ or contact us!