New PepMix Peptide Pools for M. tuberculosis!

For education only

This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.

Incoming! New PepMix Peptide Pools for M. tuberculosis!

Published on 25/04/2023

Mycobacterium tuberculosis spreads mainly via aerosols and causes a wide range of symptoms, such as long-lasting coughs, hemoptysis, chest pain, fever, potentially affecting kidneys and spine. The bacterium evades immune response by hiding inside alveolar macrophages after phagocytosis, and making use of several mechanisms to avoid its elimination from within the macrophage, e.g. inhibition of lysosome fusion.

With antibiotic-resistant and drug-resistant tuberculosis being on the rise, close epidemiological monitoring and drug- and vaccine development are imperative in combatting the spread.

Therefore, we added another set of new PepMix Peptide Pools to our extensive catalog, that now covers the main antigens for secretion system -, secretion-associated, and extracellular immunogenic proteins. JPT now offers 17 different PepMix Peptide Pools, 1 PepStar Peptide Microarray, and 1 PepMix Pan Select!

PepMix M. tuberculosisProtein-spanning overlapping peptide pools for antigen-specific stimulation of T cells covering: ACR, Ag85A, Ag85B, CFP-10, ESAT-6, EspA, EsxN, HBHA, HRP1, MPT64, PPE68, RpfA, RpfD, Rv1733c, TB10.4, TB8.4, VapB47

PepStar Antigen Collection M. tuberculosis Ultra Peptide microarray with overlapping peptides from 40 antigens of MTB reference strain H37Rv supplemented by 354 homologous antigens found in 17 other M. tuberculosis strains.

PepMix Pan-Tuberculosis BCG SelectTuberculosis-specific pool of 150 peptides stemming from selected proteins, that elicit a strong immune response in T cell assays (e.g. ELISPOT).

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JPT's Tumor Associated Antigens for Research

PepMix™ Peptide Pools are instrumental in cancer immunotherapy, particularly for exploring tumor-associated antigens and improving T cell responses. JPT’s PepMix™ Peptide Pools support the development of novel cancer vaccines and therapeutic strategies targeting tumor-specific markers. Below, you will find key studies referencing JPT’s PepMix™ Peptide Pools in research.

Source: jpt.com ↗

TCR-T Research with PepMix™ Peptide Pools for Key Cancer Targets

Published on 15/05/2025 T-cell receptor-engineered T-cell therapy (TCR-T) is rapidly gaining momentum in the field of cancer immunotherapy. Unlike CAR-T cells, which recognize surface antigens, TCR-T cells can detect and eliminate cancer cells based on intracellular tumor-associated antigens presented by MHC molecules, offering broader therapeutic opportunities across solid and hematologic malignancies. A recent comprehensive review (Zhang et al., 2023) highlights the 16 major cancer targets currently pursued in TCR-T clinical trials. JPT is proud to support researchers in this exciting field by offering PepMix™ Peptide Pools for 15 of these 16 critical targets — and a partial PepMix™ for the remaining one (EGFRvIII). Main TCR-T Targets Available as PepMix™ Peptide Pools: AFP (Alpha-fetoprotein) EGFRvIII (partially available as ErbB2-ICD and ErbB2-ECD) EBV (Epstein-Barr Virus) HA-1 HBV (Hepatitis B Virus) HPV (Human Papillomavirus) KK-LC-1 KRAS (mutated) MAGE-A1 MAGE-A3 MAGE-A4 MAGE-A10 MART-1 Mesothelin NY-ESO-1 WT1 Check all our tumor-associated antigen peptide pools and our more than 1500 individual epitope peptides. Why Choose PepMix™ Peptide Pools for TCR-T Research? Comprehensive Antigen Coverage: Each PepMix™ consists of overlapping peptides that span the full protein sequence, ensuring maximal coverage of known and novel epitopes — ideal for discovery, monitoring, and functional assays. High Quality and Batch Consistency: Our optimized synthesis and stringent QC processes guarantee high purity, reproducibility, and biological performance you can trust for clinical research. Experience with Difficult Sequences: Hydrophobic and aggregation-prone sequences? No problem. JPT’s proven expertise ensures even challenging targets are fully represented in your peptide pool. Immediate Availability: More than 450 different catalog PepMix™ peptide pools are available from stock — enabling faster project initiation and smoother workflows. In case we do not have you antigen, contact us! We can provide it to you as a custom PepMix™ Peptide Pool. Accelerate Your TCR-T Research PepMix™ Peptide Pools are widely used for: Screening TCRs for target specificity Monitoring T-cell responses post-infusion Identifying immunodominant epitopes Supporting preclinical and translational studies Advance your TCR-T programs with reliable tools trusted by researchers worldwide and learn more about The World of PepMix™ or contact us!

Source: jpt.com ↗

Practical and safety references

These excerpts are educational, not personalised medical instructions.

Potential benefits

Benefits of Custom PepMix™ Peptide Pools

Overlapping peptide pools are preferable to whole proteins for antigen-specific T-cell stimulation because: Simultaneous detection of CD4+ and CD8+ responses in a single sample Equivalent or better stimulation T-cell responses compared to whole protein antigens Antigen spanning peptide pools stimulate T-cells in an HLA independent manner All epitopes covered, epitope spreading addressed Purified peptide pools eliminate risk of toxic inhibition of T-cell responses No false positive T-cell stimulation caused by deletion peptides Superior control compared to phytohemagglutinin (PHA) and concanavalin A (ConA) Improved responses in stored blood and PBM cells compared to whole proteins High-batch-to-batch reproducibility Reliable chemical and biochemical quality control and quality assurance for peptide synthesis and peptide pool generation Prolonged shelf stability when stored freeze dried

Source: jpt.com ↗

About the author

Peptide Therapy Guide Editorial Team

Editorial team for Peptide Therapy Guide.

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Incoming! New PepMix Peptide Pools for M. tuberculosis!

JPT's Tumor Associated Antigens for Research

TCR-T Research with PepMix™ Peptide Pools for Key Cancer Targets

Benefits of Custom PepMix™ Peptide Pools

Peptide Therapy Guide Editorial Team

Custom SIL peptides - peptide pools

Custom PepMix™ Peptide Pools | JPT

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