Neocutis Bio Serum Firm Versus SkinBetter Science Interufse Intensive Treatment Lines

Neocutis Bio Serum Firm Versus SkinBetter Science Interufse Intensive Treatment Lines

This serum is formulated around Aminopropyl Ascorbyl Phosphate to reduce redness and brighten.

This anti-aging serum is formulated around Acetyl Glucosamine and Tetrahexyldecyl Ascorbate to soften the look of wrinkles and refine skin texture.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Caprylic/Capric Triglyceride

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Squalane

Aminopropyl Ascorbyl Phosphate

Sodium Hyaluronate

Hydrolyzed Sodium Hyaluronate

Cutaneous Lysate

Tetrapeptide-21

Palmitoyl Tripeptide-1 Acetate

Butylene Glycol

Ethylhexylglycerin

Pullulan

Acetyl Glucosamine

Ethylene/Acrylic Acid Copolymer

Polysorbate 60

Proline

Arginine

Glycine

Glutamine

Chlorphenesin

Nannochloropsis Oculata Extract

Capryloyl Carnosine

Poloxamer 338

Silica

Trifluoroacetyl Tripeptide-2

Dextran

Sorbitan Isostearate

Potassium Sorbate

Sodium Benzoate

Tocopherol

Disodium EDTA

Sodium Hydroxide

Phenoxyethanol

Water, Glycerin, Caprylic/Capric Triglyceride, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Squalane, Aminopropyl Ascorbyl Phosphate, Sodium Hyaluronate, Hydrolyzed Sodium Hyaluronate, Cutaneous Lysate, Tetrapeptide-21, Palmitoyl Tripeptide-1 Acetate, Butylene Glycol, Ethylhexylglycerin, Pullulan, Acetyl Glucosamine, Ethylene/Acrylic Acid Copolymer, Polysorbate 60, Proline, Arginine, Glycine, Glutamine, Chlorphenesin, Nannochloropsis Oculata Extract, Capryloyl Carnosine, Poloxamer 338, Silica, Trifluoroacetyl Tripeptide-2, Dextran, Sorbitan Isostearate, Potassium Sorbate, Sodium Benzoate, Tocopherol, Disodium EDTA, Sodium Hydroxide, Phenoxyethanol

C12-15 Alkyl Benzoate

PEG-16 Macadamia Glycerides

Dimethicone

Alcohol Denat.

Sodium Citrate

Tetrahexyldecyl Ascorbate

Hydroxyproline

Acetyl Hexapeptide-8

Hexapeptide-48 Hcl

Palmitoyl Tripeptide-1

Palmitoyl Tetrapeptide-7

Dipeptide Diaminobutyroyl Benzylamide Diacetate

Sodium Acetylated Hyaluronate

Pisum Sativum Extract

Glycine Soja Seed Extract

Glucosamine Hcl

Ophiopogon Japonicus Root Extract

Bambusa Vulgaris Leaf/Stem Extract

Hydrolyzed Lupine Protein

Oleic Acid

C18-36 Acid Glycol Ester

PEG-7 Trimethylolpropane Coconut Ether

Sorbitan Laurate

Hexylene Glycol

Polyisobutene

C18-36 Acid Triglyceride

Carbomer

Acrylates Copolymer

Citric Acid

Caprylyl Glycol

Water, C12-15 Alkyl Benzoate, Glycerin, PEG-16 Macadamia Glycerides, Dimethicone, Acetyl Glucosamine, Alcohol Denat., Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Sodium Citrate, Tetrahexyldecyl Ascorbate, Sodium Hyaluronate, Glycine, Hydroxyproline, Proline, Acetyl Hexapeptide-8, Hexapeptide-48 Hcl, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Sodium Acetylated Hyaluronate, Pisum Sativum Extract, Glycine Soja Seed Extract, Glucosamine Hcl, Ophiopogon Japonicus Root Extract, Bambusa Vulgaris Leaf/Stem Extract, Hydrolyzed Lupine Protein, Oleic Acid, Sorbitan Isostearate, C18-36 Acid Glycol Ester, PEG-7 Trimethylolpropane Coconut Ether, Sorbitan Laurate, Hexylene Glycol, Polyisobutene, C18-36 Acid Triglyceride, Carbomer, Acrylates Copolymer, Citric Acid, Caprylyl Glycol, Ethylhexylglycerin, Potassium Sorbate, Phenoxyethanol

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Acetyl Glucosamine is an antioxidant and humectant. It is an amino acid sugar and is naturally found in our skin.

The cool thing about this ingredient? It helps the skin produce hyaluronic acid and boost hydration. It also has antioxidant benefits to protect skin cells.

When paired with niacinamide, Acetyl Glucosamine has been shown to be effective at reducing discoloration.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Glycine is the smallest amino acid and a key building block of collagen. It's part if your skin's Natural Moisturizing Factor (NMF), or the water-loving molecules in your outermost layer of skin (stratum corneum) that keeps everything hydrated and happy.

A study from 2022 found that an amino acid complex featuring taurine, arginine, and glycine significantly reduced skin irritation, improved redness, and accelerated the skin repair process.

This is a synthetic polymer. It helps improve the texture of products by adding thickness and gel-like feel.

It is also an emulsifer, meaning it prevents ingredients such as oil and water from separating. It also helps evenly disperse other ingredients.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Potassium Sorbate is a preservative used to prevent yeast and mold in products. It is commonly found in both cosmetic and food products.

This ingredient comes from potassium salt derived from sorbic acid. Sorbic acid is a natural antibiotic and effective against fungus.

Both potassium sorbate and sorbic acid can be found in baked goods, cheeses, dried meats, dried fruit, ice cream, pickles, wine, yogurt, and more.

You'll often find this ingredient used with other preservatives.

Proline is a non-essential amino acid, meaning your body can make it on its own. In skincare, it is a skin conditioning ingredient that keeps skin soft and hydrated.

It makes up about 23% of the collagen molecule (collagen is the protein responsible for keeping your skin firm) and is involved in your skin's natural hyaluronic acid production. When applied topically, proline can penetrate the skin fairly well due to its small molecular size.

Reviews of this ingredient have found it to be neither a dermal irritant nor a sensitizer.

Fun fact: Proline can be found in protein-rich foods like meat, fish, eggs, and dairy.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Sorbitan Isostearate is an emulsifer. It is created from isostearic acid and sorbitol.

As an emulsifier, it keeps the water and oil ingredients from separating. This keeps formulas stable and smooth.

In a 24 hour occlusive patch test on 56 subjects, 10% sorbitan isostearate was completely non-irritating. Most formulas use less than 10%.

Because it's a fatty acid ester, it may not be fungal acne safe since the Malassezia yeast can utilize it as a nutrient source.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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