Missha Time Revolution Night Repair Ampoule 5x Versus Estée Lauder Advanced Night Repair Eye Concentrate Matrix Synchronized Recovery Complex

Missha Time Revolution Night Repair Ampoule 5x Versus Estée Lauder Advanced Night Repair Eye Concentrate Matrix Synchronized Recovery Complex

This barrier-repair ampoule is formulated around Bifida Ferment Lysate and Niacinamide to strengthen the skin barrier and soften the look of wrinkles.

This barrier-repair eye moisturizer is formulated around Bifida Ferment Lysate and Caffeine to strengthen the skin barrier and soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Bifida Ferment Lysate

Butylene Glycol

1,2-Hexanediol

Glycerin

Betaine

Propanediol

Water

Chondrus Crispus Extract

Saccharum Officinarum Extract

Pentylene Glycol

Niacinamide

Polyquaternium-51

Diethoxyethyl Succinate

Squalane

Panthenol

Polyglyceryl-10 Laurate

Hydrogenated Lecithin

Carbomer

Lactobacillus Ferment

Lactobacillus Ferment Lysate

Leuconostoc/Radish Root Ferment Filtrate

Lactococcus Ferment

Lactobacillus/Acerola Cherry Ferment

Lactobacillus/Soybean Ferment Extract

Lactobacillus/Punica Granatum Fruit Ferment Extract

Lactococcus Ferment Lysate

Bifida Ferment Filtrate

Tromethamine

Solanum Melongena Fruit Extract

Daucus Carota Sativa Root Extract

Brassica Oleracea Capitata Leaf Extract

Beta Vulgaris Root Extract

Vaccinium Angustifolium Fruit Extract

Ethylhexylglycerin

Xanthan Gum

Aspergillus Ferment

Swiftlet Nest Extract

Dextrin

Theobroma Cacao Extract

Adenosine

Citrus Aurantium Bergamia Fruit Oil

Pelargonium Graveolens Flower Oil

Citrus Aurantium Dulcis Peel Oil

Lavandula Angustifolia Oil

Anthemis Nobilis Flower Oil

Santalum Album Oil

Limonene

Disodium EDTA

Sodium Hyaluronate

Helianthus Annuus Seed Oil

Lupinus Albus Seed Extract

Tocopherol

Ceramide NP

Cholesterol

Bifida Ferment Lysate, Butylene Glycol, 1,2-Hexanediol, Glycerin, Betaine, Propanediol, Water, Chondrus Crispus Extract, Saccharum Officinarum Extract, Pentylene Glycol, Niacinamide, Polyquaternium-51, Diethoxyethyl Succinate, Squalane, Panthenol, Polyglyceryl-10 Laurate, Hydrogenated Lecithin, Carbomer, Lactobacillus Ferment, Lactobacillus Ferment Lysate, Leuconostoc/Radish Root Ferment Filtrate, Lactococcus Ferment, Lactobacillus/Acerola Cherry Ferment, Lactobacillus/Soybean Ferment Extract, Lactobacillus/Punica Granatum Fruit Ferment Extract, Lactococcus Ferment Lysate, Bifida Ferment Filtrate, Tromethamine, Solanum Melongena Fruit Extract, Daucus Carota Sativa Root Extract, Brassica Oleracea Capitata Leaf Extract, Beta Vulgaris Root Extract, Vaccinium Angustifolium Fruit Extract, Ethylhexylglycerin, Xanthan Gum, Aspergillus Ferment, Swiftlet Nest Extract, Dextrin, Theobroma Cacao Extract, Adenosine, Citrus Aurantium Bergamia Fruit Oil, Pelargonium Graveolens Flower Oil, Citrus Aurantium Dulcis Peel Oil, Lavandula Angustifolia Oil, Anthemis Nobilis Flower Oil, Santalum Album Oil, Limonene, Disodium EDTA, Sodium Hyaluronate, Helianthus Annuus Seed Oil, Lupinus Albus Seed Extract, Tocopherol, Ceramide NP, Cholesterol

Dimethicone

Isohexadecane

Bis-PEG-18 Methyl Ether Dimethyl Silane

PEG-10 Dimethicone

Disteardimonium Hectorite

Isopropyl Isostearate

PPG-15 Stearyl Ether

Sucrose

Trehalose

Adansonia Digitata Seed Extract

Tripeptide-32

Faex Extract

Algae Extract

Sodium Rna

Hydrolyzed Algin

Caffeine

Hydroxyethyl Urea

Aminopropyl Ascorbyl Phosphate

Cucumis Sativus Fruit Extract

Anthemis Nobilis Flower Extract

Hordeum Vulgare Extract

Silybum Marianum Extract

Glycine Soja Seed Extract

Camelina Sativa Seed Oil

Sorbitol

Betula Alba Bark Extract

Scutellaria Baicalensis Root Extract

Morus Bombycis Root Extract

Poria Cocos Sclerotium Extract

Tocopheryl Acetate

Propylene Glycol Dicaprate

Sodium Polyaspartate

Phytosphingosine

Polysilicone-11

Isododecane

Helianthus Annuus Seed Extract

Polyethylene

Propylene Carbonate

Polyacrylate Crosspolymer-6

Lecithin

Glucose

Fructose

T-Butyl Alcohol

BHT

Hydroxyacetophenone

Sodium Dehydroacetate

Potassium Sorbate

Phenoxyethanol

CI 77491

Water, Dimethicone, Bifida Ferment Lysate, Isohexadecane, Glycerin, Butylene Glycol, Bis-PEG-18 Methyl Ether Dimethyl Silane, PEG-10 Dimethicone, Disteardimonium Hectorite, Isopropyl Isostearate, PPG-15 Stearyl Ether, Sucrose, Trehalose, Adansonia Digitata Seed Extract, Tripeptide-32, Faex Extract, Sodium Hyaluronate, Lactobacillus Ferment, Algae Extract, Sodium Rna, Hydrolyzed Algin, Caffeine, Hydroxyethyl Urea, Aminopropyl Ascorbyl Phosphate, Cucumis Sativus Fruit Extract, Anthemis Nobilis Flower Extract, Hordeum Vulgare Extract, Silybum Marianum Extract, Glycine Soja Seed Extract, Camelina Sativa Seed Oil, Sorbitol, Betula Alba Bark Extract, Scutellaria Baicalensis Root Extract, Morus Bombycis Root Extract, Poria Cocos Sclerotium Extract, Tocopheryl Acetate, Propylene Glycol Dicaprate, Sodium Polyaspartate, Hydrogenated Lecithin, Phytosphingosine, Ethylhexylglycerin, Polysilicone-11, Isododecane, Helianthus Annuus Seed Extract, Polyethylene, Propylene Carbonate, Polyacrylate Crosspolymer-6, Lecithin, Glucose, Fructose, T-Butyl Alcohol, Disodium EDTA, BHT, Hydroxyacetophenone, Sodium Dehydroacetate, Potassium Sorbate, Phenoxyethanol, CI 77491

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Bifida Ferment Lysate is a postbiotic ingredient made by fermenting Bifidobacterium to extract a nutrient-rich mix of peptides, amino acids, vitamins, organic acids, and polysaccharides.

These components are basically the building blocks that your skin already uses to stay hydrated, repair itself, and maintain its barrier. That's why this ingredient helps your skin hold onto moisture and stay resilient against irritation.

One in-vitro study found that this ingredient tells your skin cells to produce more of the proteins (filaggrin, loricrin, and involucrin) for building a strong and healthy barrier. This study also found this ingredient to be a solid antioxidant that helped neutralize damage against UV and pollution.

A study with people from 2010 found that sensitive, reactive skin using a cream with 10% of this ingredient for a month became noticeably less dry, less reactive, and harder to irritate compared to the group using a plain cream.

In short, this ingredient is a well-tolerated ingredient that can help with barrier repair, antioxidant protection, and calming reactive skin.

This ingredient is generally considered fungal acne (Malassezia) safe; Bifidobacterium is a bacterium, not a yeast or fungus.

The fungal acne concern with fermented ingredients mainly applies to yeast-derived ferments like Saccharomyces and Galactomyces, because those are in the same kingdom as Malassezia and could theoretically contain residual compounds that feed it.

Bifida is a completely different organism, so on its own it doesn't provide a food source for the Malassezia yeast that causes fungal acne.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.

This ingredient mainly works behind the scenes and helps with:

On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.

One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).

Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.

You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.

Ethylhexylglycerin is created from glycerin. It is a multitasker ingredient that:

The CIR Expert Panel found minimal skin absorption or sensitization of any kind in a safety assessment. Though this ingredient is considered well-tolerated, a small number of cases of allergic dermatitis have been published since 2002. Just be sure to patch test if you are unsure.

Industry-reported use ranges from 8% in rinse-off products and 2% in leave-on formulations.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Hydrogenated Lecithin is a more stable version of lecithin.

It's made by taking lecithin (a phospholipid commonly found in soybeans and egg yolks) and hydrogenating it. This just means the unsaturated fatty acids are turned into saturated ones so they don't go bad as easily.

This ingredient is an emollient, emulsifier, and penetration enhancer. As an emollient, it helps soften and hydrate skin by trapping moisture within. As an emulsifier, it prevents oil and water ingredients from separating.

Hydrogenated Lecithin can form tiny spherical structures made of phospholipid bilayers called liposomes. These liposomes are able to capture compounds inside their structure and deliver them through the skin barrier.

Because phospholipids are a natural component of our cell membranes, this ingredient is inherently compatible with skin.

A 2021 study found lecithin-based surfactants were less harsh and more tolerable comared to Sodium Lauryl Sulfate (SLS).

This ingredient is made when the Lactobacillus bacteria (the same kind that makes yogurt and kimchi) are allowed to ferment a nutrient medium.

As it ferments, it collects lactic acid, peptides, enzymes, and other bioactive metabolites to provide:

A 2023 review noted that probiotic fermentation ingredients like this one can enhance antioxidant capacity, reduce UV-induced oxidative damage, and support barrier function.

One clinical study from the same year showed a Lactobacillus ferment lysate significantly reduced transepidermal water loss and improved skin hydration.

Another review highlighted that topical Lactobacillus-based preparations can improve ceramide levels in the stratum corneum, support barrier integrity, and even help reduce S. aureus colonization in atopic dermatitis.

Why is this so cool?

Basically, your skin's outer layer works as a brick wall; skin cells are bricks and ceramides are the mortar holding it together. Moisture escapes, irritants get in, and your skin gets dry and reactive when ceramide levels drop. On top of that, "bad" skin bacteria S. aureus loves to move in when your barrier is weak to make inflammation and irritation worse.

So Lactobacillus ferment is basically patching the wall and evicting the troublemaker when it boosts ceramide production and help keep S. aureus in check.

On top of all this, it also acts as a mild antimicrobial preservative booster.

Just so you know, most studies focus on specific strains or the lysate form rather than this generic "Lactobacillus Ferment", so results can vary.

Though it's a promising ingredient, it doesn't have decades of robust clinical data behind it just yet.

Lactobacillus Ferment is generally considered safe for fungal-acne prone skin. The key thing to understand is that it comes from bacteria, not yeast or fungus.

Yeast-derived ferments (like galactomyces) have been shown to activate a protein that's linked to Malassezia-related skin issues whereas lactobacillus doesn't have that problem.

Its byproducts also don't contain the types of fatty acids (C11-24 chain lengths) that Malassezia feeds on.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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