ma:nyo Bifida Complex Ampoule Versus Estée Lauder Advanced Night Repair Synchronized Multi-Recovery Complex Serum

ma:nyo Bifida Complex Ampoule Versus Estée Lauder Advanced Night Repair Synchronized Multi-Recovery Complex Serum

This barrier-repair ampoule is formulated around Bifida Ferment Lysate and Niacinamide to strengthen the skin barrier and soften the look of wrinkles.

This barrier-repair serum is formulated around Bifida Ferment Lysate and Sodium Hyaluronate to strengthen the skin barrier and soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Bifida Ferment Lysate 60%

Lactobacillus/Pumpkin Fruit Ferment Filtrate 30.1%

Niacinamide

Butylene Glycol

Acetyl Hexapeptide-8

Aureobasidium Pullulans Ferment

Hydrolyzed Algin

Caffeine

Panax Ginseng Root Extract

Panax Ginseng Callus Culture Extract

Glycerin

Epigallocatechin Gallate

Zanthoxylum Piperitum Fruit Extract

Pulsatilla Koreana Extract

Usnea Barbata Extract

Copper Tripeptide-1

Physalis Alkekengi Fruit Extract

Methyl Gluceth-20

Sodium Hyaluronate

Adenosine

Bifida Ferment Lysate 60%, Lactobacillus/Pumpkin Fruit Ferment Filtrate 30.1%, Niacinamide, Butylene Glycol, Acetyl Hexapeptide-8, Aureobasidium Pullulans Ferment, Hydrolyzed Algin, Caffeine, Panax Ginseng Root Extract, Panax Ginseng Callus Culture Extract, Glycerin, Epigallocatechin Gallate, Zanthoxylum Piperitum Fruit Extract, Pulsatilla Koreana Extract, Usnea Barbata Extract, Copper Tripeptide-1, Physalis Alkekengi Fruit Extract, Methyl Gluceth-20, Sodium Hyaluronate, Adenosine

Water

Bifida Ferment Lysate

PEG-8

Propanediol

Bis-PEG-18 Methyl Ether Dimethyl Silane

Glycereth-26

PEG-75

Adansonia Digitata Seed Extract

Tripeptide-32

Faex Extract

Lactobacillus Ferment

Cola Acuminata Seed Extract

Anthemis Nobilis Flower Extract

Pantethine

Lecithin

Sodium Rna

Bisabolol

Squalane

Oleth-3 Phosphate

Caprylyl Glycol

Oleth-3

Oleth-5

Choleth-24

Hydrogenated Lecithin

Jojoba Wax PEG-120 Esters

Ceteth-24

Tocopheryl Acetate

Carbomer

Triethanolamine

Tetrasodium EDTA

BHT

Xanthan Gum

Potassium Sorbate

Disodium EDTA

Phenoxyethanol

CI 14700

CI 19140

Water, Bifida Ferment Lysate, PEG-8, Propanediol, Bis-PEG-18 Methyl Ether Dimethyl Silane, Methyl Gluceth-20, Glycereth-26, PEG-75, Butylene Glycol, Adansonia Digitata Seed Extract, Tripeptide-32, Sodium Hyaluronate, Faex Extract, Lactobacillus Ferment, Cola Acuminata Seed Extract, Anthemis Nobilis Flower Extract, Hydrolyzed Algin, Pantethine, Caffeine, Lecithin, Sodium Rna, Bisabolol, Squalane, Glycerin, Oleth-3 Phosphate, Caprylyl Glycol, Oleth-3, Oleth-5, Choleth-24, Hydrogenated Lecithin, Jojoba Wax PEG-120 Esters, Ceteth-24, Tocopheryl Acetate, Carbomer, Triethanolamine, Tetrasodium EDTA, BHT, Xanthan Gum, Potassium Sorbate, Disodium EDTA, Phenoxyethanol, CI 14700, CI 19140

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Bifida Ferment Lysate is a postbiotic ingredient made by fermenting Bifidobacterium to extract a nutrient-rich mix of peptides, amino acids, vitamins, organic acids, and polysaccharides.

These components are basically the building blocks that your skin already uses to stay hydrated, repair itself, and maintain its barrier. That's why this ingredient helps your skin hold onto moisture and stay resilient against irritation.

One in-vitro study found that this ingredient tells your skin cells to produce more of the proteins (filaggrin, loricrin, and involucrin) for building a strong and healthy barrier. This study also found this ingredient to be a solid antioxidant that helped neutralize damage against UV and pollution.

A study with people from 2010 found that sensitive, reactive skin using a cream with 10% of this ingredient for a month became noticeably less dry, less reactive, and harder to irritate compared to the group using a plain cream.

In short, this ingredient is a well-tolerated ingredient that can help with barrier repair, antioxidant protection, and calming reactive skin.

This ingredient is generally considered fungal acne (Malassezia) safe; Bifidobacterium is a bacterium, not a yeast or fungus.

The fungal acne concern with fermented ingredients mainly applies to yeast-derived ferments like Saccharomyces and Galactomyces, because those are in the same kingdom as Malassezia and could theoretically contain residual compounds that feed it.

Bifida is a completely different organism, so on its own it doesn't provide a food source for the Malassezia yeast that causes fungal acne.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Caffeine is a naturally occurring plant compound found in coffee beans, tea leaves, cocoa pods, and guarana.

As an antioxidant, caffeine protects your skin from free radical damage caused by UV exposure and envionrmnetal stressors.

Early research also shows that caffeine can help calm redness, soothe irritated skin, and support hair growth by stimulating microcirculation in the scalp.

You might have seen eye creams marketing caffeine as a depuffing ingredient. This is because it is a vasoconstrictor meaning it can temporarily constrict blood vessels, though clinical evidence for this specific use is still limited.

Most skincare products contain this ingredient at concentrations between 1-6%. It is able to penetrate skin easily regardless of skin type or thickness.

Just so you know, a very small number of case reports describe caffeine-induced allergy. This ingredient is generally well-tolerated, non-irritating, and non-sensitizing for the majority of people.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

This ingredient is made from brown seaweed and is often used to improve the texture of products.

According to a manufacturer, this is a lightweight ingredient and a smaller form of algin. This allows it to be easily mixed with water and improve the spreadability of products.

It also has conditioning properties that mostly sits on the surface of skin as an emollient. Some lab research has explored it in anti-aging formulas, but the results were modest.

Methyl Gluceth-20 is a humectant. Humectants help draw moisture from the air to your skin.

It is created by combining polyethylene glycol with glucose.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

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