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MEDI-PEEL Peptide9 Volume White Cica Essence Versus Estée Lauder Advanced Night Repair Synchronized Multi-Recovery Complex Serum

MEDI-PEEL Peptide9 Volume White Cica Essence Versus Estée Lauder Advanced Night Repair Synchronized Multi-Recovery Complex Serum This anti-aging essence is formulated around Niacinamide and Centella Asiatica Extract to soften the look of wrinkles and calm redn

Written by Peptide Therapy Guide Editorial Team
For education only

This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.

MEDI-PEEL Peptide9 Volume White Cica Essence Versus Estée Lauder Advanced Night Repair Synchronized Multi-Recovery Complex Serum

This anti-aging essence is formulated around Niacinamide and Centella Asiatica Extract to soften the look of wrinkles and calm redness.

This barrier-repair serum is formulated around Bifida Ferment Lysate and Sodium Hyaluronate to strengthen the skin barrier and soften the look of wrinkles.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Methylpropanediol

Methyl Perfluoroisobutyl Ether

Hydrogenated Polyisobutene

Butylene Glycol Dicaprylate/Dicaprate

Caprylic/Capric Triglyceride

Methyl Perfluorobutyl Ether

Niacinamide

Cyclopentasiloxane

Cetearyl Alcohol

Cyclohexasiloxane

Elaeis Guineensis Oil

Sodium Myristoyl Glutamate

Arginine

Glyceryl Stearate

PEG-100 Stearate

Decyl Glucoside

Betaine

Hydrogenated Lecithin

Hydroxyethyl Urea

Elaeis Guineensis Kernel Oil

Dimethicone

Decylene Glycol

Ammonium Acryloyldimethyltaurate/Vp Copolymer

Myristic Acid

Hexylene Glycol

Carbomer

Propanediol

Eucalyptus Globulus Leaf Extract

Juniperus Communis Fruit Extract

Butylene Glycol

Dimethicone/Vinyl Dimethicone Crosspolymer

Glyceryl Acrylate/Acrylic Acid Copolymer

Sodium Hyaluronate Crosspolymer

Urea

Allantoin

Ammonium Lactate

Adenosine

Sodium Hyaluronate

Hydrolyzed Glycosaminoglycans

Laureth-23

Propylene Glycol

Disodium EDTA

Buteth-3

Centella Asiatica Extract

Centella Asiatica Leaf Extract

Anthemis Nobilis Flower Water

Argania Spinosa Kernel Oil

Camellia Sinensis Leaf Extract

Magnolia Officinalis Bark Extract

Fructan

Taraxacum Officinale Rhizome/Root Extract

Sodium Benzotriazolyl Butylphenol Sulfonate

Benzyl Glycol

Alcohol Denat.

Decyl Alcohol

Tris(Tetramethylhydroxypiperidinol)Citrate

Hydrolyzed Hyaluronic Acid

Glucose

Desamido Collagen

Hydrolyzed Collagen

Tranexamic Acid

Tributyl Citrate

Trideceth-6

Sodium Polyacrylate

Pentylene Glycol

Hydrogenated Polydecene

Glyceryl Polymethacrylate

Anemarrhena Asphodeloides Root Extract

Chamaecyparis Obtusa Leaf Extract

Asiaticoside

Origanum Vulgare Leaf Extract

Salix Alba Bark Extract

Hyaluronic Acid

Lactobacillus/Soybean Ferment Extract

Cinnamomum Cassia Bark Extract

Scutellaria Baicalensis Root Extract

Portulaca Oleracea Extract

Sorbitan Laurate

Polysorbate 20

Raspberry Ketone

Polysorbate 80

Chondrus Crispus Extract

Hydroxyethylcellulose

Acetyl Dipeptide-1 Cetyl Ester

Astaxanthin

Hydrolyzed Elastin

Palmitoyl Tripeptide-5

Madecassoside

Madecassic Acid

Acetyl Hexapeptide-8

Copper Tripeptide-1

Asiatic Acid

Oligopeptide-29

Oligopeptide-32

Palmitoyl Tetrapeptide-7

Palmitoyl Tripeptide-1

Palmitoyl Oligopeptide

Palmitoyl Pentapeptide-4

1,2-Hexanediol

Ethylhexylglycerin

Totarol

Caprylyl Glycol

Parfum

CI 42090

CI 15985

CI 19140

Water, Glycerin, Methylpropanediol, Methyl Perfluoroisobutyl Ether, Hydrogenated Polyisobutene, Butylene Glycol Dicaprylate/Dicaprate, Caprylic/Capric Triglyceride, Methyl Perfluorobutyl Ether, Niacinamide, Cyclopentasiloxane, Cetearyl Alcohol, Cyclohexasiloxane, Elaeis Guineensis Oil, Sodium Myristoyl Glutamate, Arginine, Glyceryl Stearate, PEG-100 Stearate, Decyl Glucoside, Betaine, Hydrogenated Lecithin, Hydroxyethyl Urea, Elaeis Guineensis Kernel Oil, Dimethicone, Decylene Glycol, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Myristic Acid, Hexylene Glycol, Carbomer, Propanediol, Eucalyptus Globulus Leaf Extract, Juniperus Communis Fruit Extract, Butylene Glycol, Dimethicone/Vinyl Dimethicone Crosspolymer, Glyceryl Acrylate/Acrylic Acid Copolymer, Sodium Hyaluronate Crosspolymer, Urea, Allantoin, Ammonium Lactate, Adenosine, Sodium Hyaluronate, Hydrolyzed Glycosaminoglycans, Laureth-23, Propylene Glycol, Disodium EDTA, Buteth-3, Centella Asiatica Extract, Centella Asiatica Leaf Extract, Anthemis Nobilis Flower Water, Argania Spinosa Kernel Oil, Camellia Sinensis Leaf Extract, Magnolia Officinalis Bark Extract, Fructan, Taraxacum Officinale Rhizome/Root Extract, Sodium Benzotriazolyl Butylphenol Sulfonate, Benzyl Glycol, Alcohol Denat., Decyl Alcohol, Tris(Tetramethylhydroxypiperidinol)Citrate, Hydrolyzed Hyaluronic Acid, Glucose, Desamido Collagen, Hydrolyzed Collagen, Tranexamic Acid, Tributyl Citrate, Trideceth-6, Sodium Polyacrylate, Pentylene Glycol, Hydrogenated Polydecene, Glyceryl Polymethacrylate, Anemarrhena Asphodeloides Root Extract, Chamaecyparis Obtusa Leaf Extract, Asiaticoside, Origanum Vulgare Leaf Extract, Salix Alba Bark Extract, Hyaluronic Acid, Lactobacillus/Soybean Ferment Extract, Cinnamomum Cassia Bark Extract, Scutellaria Baicalensis Root Extract, Portulaca Oleracea Extract, Sorbitan Laurate, Polysorbate 20, Raspberry Ketone, Polysorbate 80, Chondrus Crispus Extract, Hydroxyethylcellulose, Acetyl Dipeptide-1 Cetyl Ester, Astaxanthin, Hydrolyzed Elastin, Palmitoyl Tripeptide-5, Madecassoside, Madecassic Acid, Acetyl Hexapeptide-8, Copper Tripeptide-1, Asiatic Acid, Oligopeptide-29, Oligopeptide-32, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Palmitoyl Oligopeptide, Palmitoyl Pentapeptide-4, 1,2-Hexanediol, Ethylhexylglycerin, Totarol, Caprylyl Glycol, Parfum, CI 42090, CI 15985, CI 19140

Bifida Ferment Lysate

PEG-8

Bis-PEG-18 Methyl Ether Dimethyl Silane

Methyl Gluceth-20

Glycereth-26

PEG-75

Adansonia Digitata Seed Extract

Tripeptide-32

Faex Extract

Lactobacillus Ferment

Cola Acuminata Seed Extract

Anthemis Nobilis Flower Extract

Hydrolyzed Algin

Pantethine

Caffeine

Lecithin

Sodium Rna

Bisabolol

Squalane

Oleth-3 Phosphate

Oleth-3

Oleth-5

Choleth-24

Jojoba Wax PEG-120 Esters

Ceteth-24

Tocopheryl Acetate

Triethanolamine

Tetrasodium EDTA

BHT

Xanthan Gum

Potassium Sorbate

Phenoxyethanol

CI 14700

Water, Bifida Ferment Lysate, PEG-8, Propanediol, Bis-PEG-18 Methyl Ether Dimethyl Silane, Methyl Gluceth-20, Glycereth-26, PEG-75, Butylene Glycol, Adansonia Digitata Seed Extract, Tripeptide-32, Sodium Hyaluronate, Faex Extract, Lactobacillus Ferment, Cola Acuminata Seed Extract, Anthemis Nobilis Flower Extract, Hydrolyzed Algin, Pantethine, Caffeine, Lecithin, Sodium Rna, Bisabolol, Squalane, Glycerin, Oleth-3 Phosphate, Caprylyl Glycol, Oleth-3, Oleth-5, Choleth-24, Hydrogenated Lecithin, Jojoba Wax PEG-120 Esters, Ceteth-24, Tocopheryl Acetate, Carbomer, Triethanolamine, Tetrasodium EDTA, BHT, Xanthan Gum, Potassium Sorbate, Disodium EDTA, Phenoxyethanol, CI 14700, CI 19140

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.

Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Carbomer is a synthetic thickening and gelling agent. It's basically the ingredient that gives a lot of serums, gels, creams, and sunscreens their smooth, non-sticky texture.

Although legally permitted at very high levels, carbomers are normally used at concentrations below 1%.

It also needs to be neutralized to actually thicken, and because it is a large molecule, it doesn't really penetrate the skin barrier.

Allergy-wise, the risk is very low. Clinical studies show carbomers have low potential for skin irritation/sensitization even at concentrations up to 100%.

A 2024 UK study patch-tested 1,302 patients and found true allergy to the parent group of carbomer to be rare with no confirmed relevant reactions.

CI 19140 is also known as Tartrazine. Tartrazine is a synthetic dye used in cosmetics, foods, and medicine to add a yellow color.

Tartrazine is created from petroleum and is water-soluble.

Some people may experience allergies from this dye, especially asthmatics and those with an aspirin intolerance.

Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.

This ingredient mainly works behind the scenes and helps with:

On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.

One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).

Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.

You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Hydrogenated Lecithin is a more stable version of lecithin.

It's made by taking lecithin (a phospholipid commonly found in soybeans and egg yolks) and hydrogenating it. This just means the unsaturated fatty acids are turned into saturated ones so they don't go bad as easily.

This ingredient is an emollient, emulsifier, and penetration enhancer. As an emollient, it helps soften and hydrate skin by trapping moisture within. As an emulsifier, it prevents oil and water ingredients from separating.

Hydrogenated Lecithin can form tiny spherical structures made of phospholipid bilayers called liposomes. These liposomes are able to capture compounds inside their structure and deliver them through the skin barrier.

Because phospholipids are a natural component of our cell membranes, this ingredient is inherently compatible with skin.

A 2021 study found lecithin-based surfactants were less harsh and more tolerable comared to Sodium Lauryl Sulfate (SLS).

Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.

It’s often used to:

Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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About the author

Peptide Therapy Guide Editorial Team

Editorial team for Peptide Therapy Guide.

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