Independent education resourceInformation here does not replace care from a qualified health professional.
Peptide Therapy GuideClear peptide education

Educational guide

MEDI-PEEL Peptide 9 Volumn Lif-Tox Eye Cream Versus Meishoku Brilliant Colors Whitening Eye Cream

MEDI-PEEL Peptide 9 Volumn Lif-Tox Eye Cream Versus Meishoku Brilliant Colors Whitening Eye Cream This anti-aging eye moisturizer is formulated around Niacinamide and Acetyl Hexapeptide-8 to soften the look of wrinkles. This brightening eye moisturizer is form

Written by Peptide Therapy Guide Editorial Team
For education only

This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.

MEDI-PEEL Peptide 9 Volumn Lif-Tox Eye Cream Versus Meishoku Brilliant Colors Whitening Eye Cream

This anti-aging eye moisturizer is formulated around Niacinamide and Acetyl Hexapeptide-8 to soften the look of wrinkles.

This brightening eye moisturizer is formulated around Tocopheryl Acetate to brighten dull-looking skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Cetyl Ethylhexanoate

Salvia Officinalis Extract

Glycerin

Niacinamide

Dipropylene Glycol

Polyglyceryl-3 Methylglucose Distearate

Cyclohexasiloxane

Cetearyl Alcohol

Stearic Acid

1,2-Hexanediol

Olea Europaea Fruit Oil

Butyrospermum Parkii Butter

Panthenol

Tremella Fuciformis Extract

Pimpinella Anisum Seed Extract

Salmon Egg Extract

Butylene Glycol

Juniperus Oxycedrus Wood Extract

Carnosine

Hydrolyzed Soy Protein

Acetyl Hexapeptide-8

Copper Tripeptide-1

Palmitoyl Pentapeptide-4

Tripeptide-1

Palmitoyl Tripeptide-1

Hexapeptide-9

Nonapeptide-1

Palmitoyl Tetrapeptide-7

Palmitoyl Tripeptide-5

Leontopodium Alpinum Callus Culture Extract

Camellia Sinensis Leaf Extract

Centella Asiatica Extract

Glycyrrhiza Glabra Root Extract

Golden Extract

Rosa Canina Fruit Extract

Chamomilla Recutita Extract

Rosmarinus Officinalis Leaf Extract

Lactobacillus

Salix Alba Bark Extract

Cinnamomum Zeylanicum Bark Extract

Origanum Vulgare Leaf Extract

Cupressus Sempervirens Leaf Extract

Portulaca Oleracea Extract

Hydrogenated Polyisobutene

Ulmus Davidiana Root Extract

Hydroxypropyltrimonium Hyaluronate

Sodium Acetylated Hyaluronate

Hydrolyzed Hyaluronic Acid

Hyaluronic Acid

Sodium Hyaluronate Crosspolymer

Hydrolyzed Sodium Hyaluronate

Potassium Hyaluronate

Hydrolyzed Collagen

Royal Jelly Extract

Argania Spinosa Kernel Oil

Squalane

Ceramide NP

Tocopheryl Acetate

Adenosine

Disodium EDTA

Betaine

Sodium Hyaluronate

Carbomer

Ethylhexylglycerin

Glyceryl Stearate

Tromethamine

Sodium Polyacrylate

Ethylhexyl Stearate

Trideceth-6

Pentylene Glycol

Caprylyl Glycol

Hydroxyacetophenone

Dipotassium Glycyrrhizate

Parfum

Water, Cetyl Ethylhexanoate, Salvia Officinalis Extract, Glycerin, Niacinamide, Dipropylene Glycol, Polyglyceryl-3 Methylglucose Distearate, Cyclohexasiloxane, Cetearyl Alcohol, Stearic Acid, 1,2-Hexanediol, Olea Europaea Fruit Oil, Butyrospermum Parkii Butter, Panthenol, Tremella Fuciformis Extract, Pimpinella Anisum Seed Extract, Salmon Egg Extract, Butylene Glycol, Juniperus Oxycedrus Wood Extract, Carnosine, Hydrolyzed Soy Protein, Acetyl Hexapeptide-8, Copper Tripeptide-1, Palmitoyl Pentapeptide-4, Tripeptide-1, Palmitoyl Tripeptide-1, Hexapeptide-9, Nonapeptide-1, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-5, Leontopodium Alpinum Callus Culture Extract, Camellia Sinensis Leaf Extract, Centella Asiatica Extract, Glycyrrhiza Glabra Root Extract, Golden Extract, Rosa Canina Fruit Extract, Chamomilla Recutita Extract, Rosmarinus Officinalis Leaf Extract, Lactobacillus, Salix Alba Bark Extract, Cinnamomum Zeylanicum Bark Extract, Origanum Vulgare Leaf Extract, Cupressus Sempervirens Leaf Extract, Portulaca Oleracea Extract, Hydrogenated Polyisobutene, Ulmus Davidiana Root Extract, Hydroxypropyltrimonium Hyaluronate, Sodium Acetylated Hyaluronate, Hydrolyzed Hyaluronic Acid, Hyaluronic Acid, Sodium Hyaluronate Crosspolymer, Hydrolyzed Sodium Hyaluronate, Potassium Hyaluronate, Hydrolyzed Collagen, Royal Jelly Extract, Argania Spinosa Kernel Oil, Squalane, Ceramide NP, Tocopheryl Acetate, Adenosine, Disodium EDTA, Betaine, Sodium Hyaluronate, Carbomer, Ethylhexylglycerin, Glyceryl Stearate, Tromethamine, Sodium Polyacrylate, Ethylhexyl Stearate, Trideceth-6, Pentylene Glycol, Caprylyl Glycol, Hydroxyacetophenone, Dipotassium Glycyrrhizate, Parfum

Placental Extract

Collagen

Coix Lacryma-Jobi Ma-Yuen Seed Extract

Diospyros Kaki Fruit Extract

PCA

Malic Acid

Oryza Sativa Bran Oil

Glycosphingolipids

Hydrogenated Lecithin

Tocopherol

Hydroxyproline

Polyglyceryl-2 Oleate

Glyceryl Stearate Se

Polyglyceryl-6 Stearate

Ethylhexyl Palmitate

Beeswax

Dimethicone

Caprylic/Capric Triglyceride

Dipentaerythrityl Hexahydroxystearate/Hexastearate/Hexarosinate

Hydrogenated Polybutene

Behenyl Alcohol

Poly(2-Methacryloyloxyethyl Phosphorylcholine-Co-N-Butyl Methacrylate)

Alcohol

Phenoxyethanol

Methylparaben

Placental Extract, Tocopheryl Acetate, Collagen, Hydrolyzed Collagen, Coix Lacryma-Jobi Ma-Yuen Seed Extract, Diospyros Kaki Fruit Extract, PCA, Malic Acid, Oryza Sativa Bran Oil, Glycosphingolipids, Hydrogenated Lecithin, Tocopherol, Hydroxyproline, Glycerin, Butylene Glycol, Pentylene Glycol, Polyglyceryl-2 Oleate, Glyceryl Stearate Se, Polyglyceryl-6 Stearate, Ethylhexyl Palmitate, Beeswax, Dimethicone, Stearic Acid, Caprylic/Capric Triglyceride, Dipentaerythrityl Hexahydroxystearate/Hexastearate/Hexarosinate, Hydrogenated Polybutene, Behenyl Alcohol, Poly(2-Methacryloyloxyethyl Phosphorylcholine-Co-N-Butyl Methacrylate), Alcohol, Phenoxyethanol, Methylparaben, Parfum

Reviews

Be the first to review

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Hydrolyzed Collagen is Collagen (usually sourced from fish, bovine, or porcine byproducts) that's been broken down into smaller peptides. This makes it water-soluble and easy to blend into formulations.

In a formula, it works mainly as a skin-conditioning and moisturizing agent.

The small peptides and amino acids (including Natural Moisturizing Factor components like Hydroxyproline, Serine, and Aspartic Acid) help the surface of the skin hold onto water, feel softer, and look temporarily plumper.

This ingredient also has mild film-forming and antioxidant properties with research showing the antioxidant effect is stronger the lower the molecular weight of the peptides.

It's worth being realistic here:

Topically applied Hydrolyzed Collagen conditions the upper layers of skin rather than rebuilding the structural collagen deep in your dermis (the wrinkle-and-firmness benefits people associate with Collagen mostly come from oral supplements in studies, not topicals).

However, recent lab and skin-model work on Hydrolyzed Fish Collagen has shown promising effects on cell viability and wound healing when used as an active.

Typical concentrations range from 0.2-2%, but the percentage can go much higher in rinse-off or hair products (sometimes even above 50%).

Clinical studies on this ingredient showed no irritation, sensitization, or phototoxicity.

If you are looking for vegan collagen, it usually goes by a different INCI name like hydrolyzed soy protein. Vegan collagen is derived from yeast, bacteria, or plant sources.

The results are varied.

A study from 2021 found hydrolyzed collagen increased elasticity and improved wrinkles in 1,125 participants between age 20 and 70. Another study found increased skin thickness in participants between the ages of 45 to 59.

However, It is difficult to prove that oral collagen will end up working on your skin. Many of the studies using hydrolyzed collagen also add several vitamins and nutrients into the test mixture as well.

Further studies are needed at this time.

Parfum is a catch-all term for an ingredient or more that is used to give a scent to products.

Also called "fragrance", this ingredient can be a blend of hundreds of chemicals or plant oils. This means every product with "fragrance" or "parfum" in the ingredients list is a different mixture.

For instance, Habanolide is a proprietary trade name for a specific aroma chemical. When used as a fragrance ingredient in cosmetics, most aroma chemicals fall under the broad labeling category of “FRAGRANCE” or “PARFUM” according to EU and US regulations.

The term 'parfum' or 'fragrance' is not regulated in many countries. In many cases, it is up to the brand to define this term.

For instance, many brands choose to label themselves as "fragrance-free" because they are not using synthetic fragrances. However, their products may still contain ingredients such as essential oils that are considered a fragrance by INCI standards.

One example is Calendula flower extract. Calendula is an essential oil that still imparts a scent or 'fragrance'.

Depending on the blend, the ingredients in the mixture can cause allergies and sensitivities on the skin. Some ingredients that are known EU allergens include linalool and citronellol.

Parfum can also be used to mask or cover an unpleasant scent.

The bottom line is: not all fragrances/parfum/ingredients are created equally. If you are worried about fragrances, we recommend taking a closer look at an ingredient. And of course, we always recommend speaking with a professional.

Pentylene Glycol (1,2-pentanediol) is a multitasking little diol with three main roles in a formula:

Research on alkanediols (the family pentylene glycol belongs to) show they work by disrupting microbial cell membranes. This disruption helps the primary preservative system in a product work more effectively at lower doses.

On the safety side, the Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe as used in current cosmetic practices + concentrations.

Typical use levels in a formula run about 1-5%.

Stearic Acid is a fatty acid that is already found in your skin. It's one of the free fatty acids that works alongside ceramides and cholesterols to maintain your barrier.

In cosmetics, it is a multitasker:

Safety-wise, the CIR Expert Panel has concluded it to be safe in cosmetics when formulated to be non-irritating and non-sensitizing.

Free stearic acid is a C18 fatty acid that the Malassezia yeast can substrate, so this ingredient may not be fungal acne safe.

Tocopheryl Acetate is a stable, shelf-friendly form of vitamin E.

Formulators love it because plain vitamin E oxidizes quickly once it hits air. This acetate version stays stable and resists going off, helping to extend a product's shelf life.

It's actually inactive on its own and works like a slow-release "storage" form; the enzymes in your skin called esterases gradually convert it into active vitamin E over time.

One in vivo study showed 5% of the acetate in the living layer of the epidermis converted to vitamin E after 5 days of application. This study also found the skin gained protection against UV damage even though the conversion was slow and small.

Once converted, vitamin E acts as a skin's main fat-soluble antioxidant that fights free radicals to protect skin from damage.

Topical vitamin E generally boosts the skin's photoprotection, and it reduced UV-damage in animal models.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

Overall, it has a pretty solid safety profile and has been found to be non-irritating and non-comedogenic. Allergic reactions may happen but stay rare due to how widely the ingredient gets used.

The concentration will vary depending on the formula; industry data shows 0.1% in baby lotions, 3% in lipsticks, and 5% in foot powders. You can also find this ingredient at 100% in a pure vitamin E oil.

Most leave-on skincare keeps it at the lower end, often between 0.5-1%.

Similar Comparisons

Connected reading

Helpful context for this guide

Source-derived material selected through this article’s indexed topics.

Research context

Read sources and limitations before applying a claim.

Where the research stands

Peptide skincare has progressed from speculative to evidence-based over the past twenty years. Early products contained unproven peptide fragments. Current formulations use compounds with clinical trial support. The nine peptides in Medi-Peel all have published research behind them. Some studies are more robust than others. GHK-Cu and palmitoyl pentapeptide-4 have the strongest evidence bases. Others have smaller or lower-quality studies. This research continues expanding. New peptides enter the market regularly. Delivery technologies improve. What works well today will likely be surpassed by tomorrow's formulations. But waiting for perfect products means never starting. Current options provide real benefits.

Source: seekpeptides.com ↗
P

About the author

Peptide Therapy Guide Editorial Team

Editorial team for Peptide Therapy Guide.

View all articles →