La Roche-Posay Toleriane Ultra Night Moisturizer Versus Biologique Recherche Crème Dermo-RL Lipid-Replenishing, Regenerating, Moisturizing Cream for the Face

La Roche-Posay Toleriane Ultra Night Moisturizer Versus Biologique Recherche Crème Dermo-RL Lipid-Replenishing, Regenerating, Moisturizing Cream for the Face

This barrier-repair night moisturizer is formulated around Squalane and Niacinamide to strengthen the skin barrier and calm redness.

This barrier-repair moisturizer is formulated around Vitis Vinifera Seed Oil and Butyrospermum Parkii Butter to strengthen the skin barrier and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Glycerin

Squalane

Propanediol

Butylene Glycol

Butyrospermum Parkii Butter

Pentylene Glycol

Niacinamide

Dimethicone

Ammonium Polyacryloyldimethyl Taurate

Polymethylsilsesquioxane

Polysorbate 20

Tocopherol

Acetyl Dipeptide-1 Cetyl Ester

Allantoin

Toluene Sulfonic Acid

Dimethiconol

Xanthan Gum

Carnosine

Disodium EDTA

Citric Acid

Aluminum Starch Octenylsuccinate

Glyceryl Acrylate/Acrylic Acid Copolymer

Water, Glycerin, Squalane, Propanediol, Butylene Glycol, Butyrospermum Parkii Butter, Pentylene Glycol, Niacinamide, Dimethicone, Ammonium Polyacryloyldimethyl Taurate, Polymethylsilsesquioxane, Polysorbate 20, Tocopherol, Acetyl Dipeptide-1 Cetyl Ester, Allantoin, Toluene Sulfonic Acid, Dimethiconol, Xanthan Gum, Carnosine, Disodium EDTA, Citric Acid, Aluminum Starch Octenylsuccinate, Glyceryl Acrylate/Acrylic Acid Copolymer

Vitis Vinifera Seed Oil

Propanediol Dicaprylate

C12-16 Alcohols

Gossypium Herbaceum Seed Oil

Pentaerythrityl Tetrastearate

Polyamide-5

Vaccinium Macrocarpon Seed Oil

Xylitylglucoside

Hydrogenated Lecithin

Palmitic Acid

Simmondsia Chinensis Seed Oil

Anhydroxylitol

Sodium Hyaluronate

Pseudoalteromonas Ferment Extract

Xylitol

Helianthus Annuus Seed Oil

Juglans Regia Seed Extract

Cananga Odorata Flower Oil

Citrus Aurantium Amara Flower Oil

Opuntia Ficus-Indica Fruit Extract

Glyceryl Stearate Citrate

Polysorbate 60

Sorbitan Isostearate

Phenoxyethanol

Rhizobian Gum

Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Chlorphenesin

Salicylic Acid

Sodium Metabisulfite

Sodium Hydroxide

Benzyl Benzoate

Benzyl Salicylate

Farnesol

Geraniol

Limonene

Linalool

Water, Vitis Vinifera Seed Oil, Butyrospermum Parkii Butter, Propanediol Dicaprylate, C12-16 Alcohols, Gossypium Herbaceum Seed Oil, Pentylene Glycol, Pentaerythrityl Tetrastearate, Polyamide-5, Vaccinium Macrocarpon Seed Oil, Xylitylglucoside, Hydrogenated Lecithin, Palmitic Acid, Glycerin, Simmondsia Chinensis Seed Oil, Anhydroxylitol, Sodium Hyaluronate, Pseudoalteromonas Ferment Extract, Xylitol, Tocopherol, Helianthus Annuus Seed Oil, Juglans Regia Seed Extract, Cananga Odorata Flower Oil, Citrus Aurantium Amara Flower Oil, Opuntia Ficus-Indica Fruit Extract, Glyceryl Stearate Citrate, Polysorbate 60, Sorbitan Isostearate, Phenoxyethanol, Rhizobian Gum, Hydroxyethyl Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Chlorphenesin, Salicylic Acid, Sodium Metabisulfite, Sodium Hydroxide, Benzyl Benzoate, Benzyl Salicylate, Farnesol, Geraniol, Limonene, Linalool

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

This ingredient is also known as shea butter. It is a plant-derived extract from the nuts of the Africa shea tree and one of the most well-studied emollients.

Because it has a high concentration of fatty acids (primarily oleic, stearic, and linoleic) it is able to form a protective barrier on the skin's surface. This helps seal in moisture and prevents transepidermal water loss (TEWL).

In vitro research found an increase in skin hydration by 58% and a decrease in TEWL by 37.8% after 24 hours of applying this ingredient (pretty impressive for a single ingredient!).

Besides hydration, shea butter also contains triterpenes that have anti-inflammatory potential. In particule, lupeol cinnamate has shown the highest anti-inflammatory activity in vivo.

Shea butter also contains vitamins A and E which may contribute to antioxidant activity.

While Shea Butter has an SPF rating of about 3-4, it is not a sunscreen replacement.

This ingredient may not be fungal acne safe because its fatty acids fall within the C11-C24 range that the Malassezia yeast can metabolize.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Pentylene Glycol (1,2-pentanediol) is a multitasking little diol with three main roles in a formula:

Research on alkanediols (the family pentylene glycol belongs to) show they work by disrupting microbial cell membranes. This disruption helps the primary preservative system in a product work more effectively at lower doses.

On the safety side, the Cosmetic Ingredient Review Expert Panel has concluded this ingredient to be safe as used in current cosmetic practices + concentrations.

Typical use levels in a formula run about 1-5%.

Tocopherol is a fat-soluble antioxidant known as Vitamin E.

You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.

Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.

It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.

This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.

Concentrations usually range from 0.1-1% in most leave-on products.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons