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La Mer The Moisturizing Soft Cream Versus Biologique Recherche Crème Masque Vernix Revitalizing, Regenerating and Protective Cream/Mask for the Face

La Mer The Moisturizing Soft Cream Versus Biologique Recherche Crème Masque Vernix Revitalizing, Regenerating and Protective Cream/Mask for the Face This barrier-repair moisturizer is formulated around Petrolatum and Cholesterol to strengthen the skin barrier

Written by Peptide Therapy Guide Editorial Team
For education only

This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.

La Mer The Moisturizing Soft Cream Versus Biologique Recherche Crème Masque Vernix Revitalizing, Regenerating and Protective Cream/Mask for the Face

This barrier-repair moisturizer is formulated around Petrolatum and Cholesterol to strengthen the skin barrier and hydrate skin.

This barrier-repair moisturizer is formulated around Lecithin and Ceramide NP to strengthen the skin barrier and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Algae Extract

Cyclopentasiloxane

Petrolatum

Glyceryl Distearate

Phenyl Trimethicone

Cyclohexasiloxane

Butylene Glycol

Cholesterol

Butyrospermum Parkii Butter

Steareth-10

Dimethicone

Glyceryl Stearate Se

Polysilicone-11

Glyceryl Triacetyl Ricinoleate

Macadamia Integrifolia Seed Oil

Glycerin

Sesamum Indicum Seed Oil

Medicago Sativa Seed Powder

Helianthus Annuus Seedcake

Prunus Amygdalus Dulcis Seed Meal

Eucalyptus Globulus Leaf Oil

Sodium Gluconate

Copper Gluconate

Calcium Gluconate

Magnesium Gluconate

Zinc Gluconate

Tocopheryl Succinate

Niacin

Sesamum Indicum Seed Powder

Water

Citrus Aurantifolia Peel Extract

Laminaria Digitata Extract

Crithmum Maritimum Extract

Salicornia Herbacea Extract

Plankton Extract

Chlorella Vulgaris Extract

Rosmarinus Officinalis Leaf Extract

Sodium Hyaluronate

Tocopheryl Acetate

Acetyl Hexapeptide-8

Caffeine

Tetrahexyldecyl Ascorbate

Palmitoyl Hexapeptide-12

Caprylic/Capric Triglyceride

Triethylhexanoin

Sodium PCA

Cetyl Alcohol

Diethylhexyl Succinate

Isocetyl Stearoyl Stearate

Cyanocobalamin

C13-14 Isoparaffin

Distearyldimonium Chloride

Dipalmitoyl Hydroxyproline

Sucrose

Hydrogenated Vegetable Oil

Trehalose

Hydrolyzed Algin

Micrococcus Lysate

Maris Sal

Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate

Lactoperoxidase

Glucose Oxidase

Urea

Glucose

Polyacrylamide

Glyceryl Polymethacrylate

PEG-8

Laureth-7

Lecithin

Triacetin

Sodium Chloride

Polyquaternium-51

Potassium Phosphate

Alcohol Denat.

Parfum

Limonene

Linalool

Hydroxycitronellal

Citronellol

Geraniol

BHT

Disodium EDTA

Sorbic Acid

Chlorphenesin

Potassium Sorbate

Phenoxyethanol

Algae Extract, Cyclopentasiloxane, Petrolatum, Glyceryl Distearate, Phenyl Trimethicone, Cyclohexasiloxane, Butylene Glycol, Cholesterol, Butyrospermum Parkii Butter, Steareth-10, Dimethicone, Glyceryl Stearate Se, Polysilicone-11, Glyceryl Triacetyl Ricinoleate, Macadamia Integrifolia Seed Oil, Glycerin, Sesamum Indicum Seed Oil, Medicago Sativa Seed Powder, Helianthus Annuus Seedcake, Prunus Amygdalus Dulcis Seed Meal, Eucalyptus Globulus Leaf Oil, Sodium Gluconate, Copper Gluconate, Calcium Gluconate, Magnesium Gluconate, Zinc Gluconate, Tocopheryl Succinate, Niacin, Sesamum Indicum Seed Powder, Water, Citrus Aurantifolia Peel Extract, Laminaria Digitata Extract, Crithmum Maritimum Extract, Salicornia Herbacea Extract, Plankton Extract, Chlorella Vulgaris Extract, Rosmarinus Officinalis Leaf Extract, Sodium Hyaluronate, Tocopheryl Acetate, Acetyl Hexapeptide-8, Caffeine, Tetrahexyldecyl Ascorbate, Palmitoyl Hexapeptide-12, Caprylic/Capric Triglyceride, Triethylhexanoin, Sodium PCA, Cetyl Alcohol, Diethylhexyl Succinate, Isocetyl Stearoyl Stearate, Cyanocobalamin, C13-14 Isoparaffin, Distearyldimonium Chloride, Dipalmitoyl Hydroxyproline, Sucrose, Hydrogenated Vegetable Oil, Trehalose, Hydrolyzed Algin, Micrococcus Lysate, Maris Sal, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Lactoperoxidase, Glucose Oxidase, Urea, Glucose, Polyacrylamide, Glyceryl Polymethacrylate, PEG-8, Laureth-7, Lecithin, Triacetin, Sodium Chloride, Polyquaternium-51, Potassium Phosphate, Alcohol Denat., Parfum, Limonene, Linalool, Hydroxycitronellal, Citronellol, Geraniol, BHT, Disodium EDTA, Sorbic Acid, Chlorphenesin, Potassium Sorbate, Phenoxyethanol

Amniotic Fluid

Lanolin Oil

Propylene Glycol

Pentylene Glycol

Sodium Acrylates Copolymer

Ethylhexyl Palmitate

Squalane

Raspberry Seed Oil/Palm Oil Aminopropanediol Esters

Hydrolyzed Placental Protein

Hydrolyzed Gelatin

Yeast Extract

Hydrolyzed Ceratonia Siliqua Seed Extract

Sodium Lauroyl Lactylate

Sodium Dehydroacetate

Luffa Cylindrica Seed Oil

Tocopherol

Dimethylmethoxy Chromanol

Embryo Extract

Helianthus Annuus Seed Oil

Ethylhexylglycerin

Ceramide NP

Potassium Sulfate

Ceramide AP

Phytosphingosine

Papain

Xanthan Gum

Carbomer

Caprylyl Glycol

Diaminopropionoyl Tripeptide-33

Ceramide EOP

Water, Amniotic Fluid, Lecithin, Lanolin Oil, Propylene Glycol, Pentylene Glycol, Sodium Acrylates Copolymer, Glycerin, Alcohol Denat., Ethylhexyl Palmitate, Squalane, Raspberry Seed Oil/Palm Oil Aminopropanediol Esters, Hydrolyzed Placental Protein, Hydrolyzed Gelatin, Yeast Extract, Hydrolyzed Ceratonia Siliqua Seed Extract, Phenoxyethanol, Sodium Lauroyl Lactylate, Sodium Dehydroacetate, Luffa Cylindrica Seed Oil, Tocopherol, Dimethylmethoxy Chromanol, Embryo Extract, Helianthus Annuus Seed Oil, Ethylhexylglycerin, Ceramide NP, Cholesterol, Potassium Sulfate, Ceramide AP, Phytosphingosine, Papain, Xanthan Gum, Carbomer, Caprylyl Glycol, Diaminopropionoyl Tripeptide-33, Ceramide EOP

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Alcohol Denat. is an alcohol with a denaturant property. It is created by mixing ethanol with other additives.

The "denat" part just means "denatured"; common denaturants include Denatonium Benzoate, t-butyl alcohol, and Diethyl Phthalate. This step makes the alcohol undrinkable (and lets brand skip taxes related to beverage alcohol).

This ingredient gets a bad rep because it is irritating and drying due to its astringent property. Astringents draw out natural oils in tissue to constrict pores and dry out your skin.

However, alcohol denat. is not all that bad.

Due to its low molecular weight, alcohol denat. tends to evaporate quickly. One study on pig skin found half of applied alcohol evaporated in 10 seconds and less than 3% stayed on skin.

This also helps other ingredients become better absorbed upon application.

Studies are conflicted about whether this ingredient causes skin dehydration. One study from 2005 found adding emollients to propanol-based sanitizer decreased skin dryness and irritation. Another study found irritation only occurs if your skin is already damaged.

Small amounts of alcohol are generally tolerated by oily skin or people who live in humid environments.

The rule of thumb is this ingredient will probably not affect your skin much if it is near the end of an ingredients list.

One thing to note: People with ALDH2 (aldehyde dehydrogenase 2) deficiency may experience skin irritation from continued alcohol use. About 8% of the world's population have this deficiency.

The Cosmetic Ingredient Review Expert Panel has determined denatured alcohols to be safe for use in concentrations between 0.05% and 12% (depending on which denaturant is used).

Also...

This ingredient has antimicrobial and solvent properties.

The antimicrobial property helps preserve products and increase their shelf life. As a solvent, it helps dissolve other ingredients.

Look for formulas that contain glycerin, hyaluronic acid, or panthenol if you want to offset any drying effect.

This ingredient will trip away your skin's natural oils/lipids that help it lock in moisture. This can worsen dryness, trigger eczema flare-ups, and aggravate rosacea.

Be sure to patch test any product with this ingredient if you have dry or sensitive skin, eczema, or rosacea.

Cholesterol is a lipid that is naturally found in human skin and is one of the three key components of your skin barrier. In skincare, it is an emollient and barrier-repairing ingredient.

It works by fitting directly into the lipid layers of skin to help restore structure and reduce transepidermal water loss (TEWL).

This is a great ingredient for dry, compromised, or aging skin; our skin starts to produce less cholesterol with age.

Research shows cholesterol works best in combination with ceramides and fatty acids, the other two major components in your skin barrier.

Cholesterol is also a well-establish penetration enhancer and can help other actives absorb more effectively.

Cosmetic-grade cholesterol is usually derived from lanolin but plant and synthetic options also exist. We recommend reaching out to the brand if you have questions about their source of cholesterol.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Lecithin is a term for a group of substances found in the cell membranes of plants, animals, and humans. They are made up of phospholipids.

Thanks to its amphiphilic structure (water-loving head and oil-loving tail), it is a true multitasker:

It plays well with most ingredients and is typically used at 0.1-1%. However, concentrations up to 50% have been reported in moisturizers.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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Peptide Therapy Guide Editorial Team

Editorial team for Peptide Therapy Guide.

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