FCCP (Carbonyl cyanide 4-(trifluoromethoxy) ...

Cat. No.: HY-100410

(Synonyms: Carbonyl cyanide 4-(trifluoromethoxy)phenylhydrazone)

120 Cited Publications

Customer Review

Based on 120 publication(s) in Google Scholar

FCCP is an uncoupler of oxidative phosphorylation (OXPHOS) in mitochondria. FCCP induces activation of PINK1 leading to Parkin Ser65 phosphorylation.

For research use only. We do not sell to patients.

• Purity: 99.69%
• CAS No.: 370-86-5
• Formula: C10H5F3N4O
• Molecular Weight:254.17

• Storage:

  Powder   -20°C, 3 years , 4°C, 2 years ; In solvent   -80°C, 1 year , -20°C, 6 months

• HY-B1756

  Rotenone

• HY-N6782

  Oligomycin

• HY-100941

  CCCP

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  2-Deoxy-D-glucose

• HY-16589

  Oligomycin A

• HY-B0389

  D-Glucose

• HY-D0985A

  TMRE

• HY-50202

  Etomoxir

• HY-15886

  Mdivi-1

• HY-100558

  Bafilomycin A1

• HY-15141

  Staurosporine

• HY-10219

  Rapamycin

Customer Validation & Images

Bio/Physico-chemical AssayCell Imaging/StainingFlow CytometryIFWBCell Proliferation/Viability Assay

• Bio/Physico-chemical Assay

• Cell Imaging/Staining

• IF

• WB

• Cell Proliferation/Viability Assay

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Assay Types

• 1/16

  FCCP purchased from MedChemExpress. Usage Cited in: Nature. 2025 Mar;639(8055):765-775. [Abstract]

  Customer Validation
  OCR of neuroendocrine (n=4) and non-neuroendocrine (n=2) SCLC cell lines after FCCP (1.5 μM, 40 min) treatment (n=6 technical replicates for each cell line).

• 1/16

  FCCP purchased from MedChemExpress. Usage Cited in: Nat Commun. 2025 Jul 30;16(1):6996. [Abstract]

  Customer Validation
  The mitophagy index of shRNA- or non-transduced 528NS and HOG-GSCs treated for 3 days with or without MitoTEMPOL (100 nM) on day 4 after shRNA transduction. FCCP (30 μM) and RA were used as positive controls.

• 1/16

  FCCP purchased from MedChemExpress. Usage Cited in: Bone Res. 2024 Aug 28;12(1):49. [Abstract]

  Customer Validation
  Immunofluorescence staining to show the CTSK expression level in osteoclasts that were treated with oligomycin A (10 nmol/L), rotenone (100 nmol/L), FCCP (1 μmol/L), 2DG (1 μmol/L) or 3BrPA (1 μmol/L) for 6 h (scale bar, 100 µm).

• 1/16

  FCCP purchased from MedChemExpress. Usage Cited in: Bone Res. 2024 Aug 28;12(1):49. [Abstract]

  Customer Validation
  Immunoblots of the pre-proenzyme and active CTSK levels in osteoclasts treated with 2DG (1 μmol/L), FCCP (1 μmol/L), rotenone (100 nmol/L) or 3-BrPA (1 μmol/L) for 10 h. The MMP-9 and CTSB expression levels were also detected. DMSO-treated osteoclasts were used as controls.

• 1/16

  FCCP purchased from MedChemExpress. Usage Cited in: Cancer Res. 2023 Dec 15;83(24):4063-4079. [Abstract]

  Customer Validation
  Viability of Glut5-overexpressing and control cells cultured for 24 hours under different conditions in the presence of Rotenone or FCCP (10 μmol/L).

• 1/16

  FCCP purchased from MedChemExpress. Usage Cited in: Nat Commun. 2022 May 13;13(1):2673. [Abstract]

  Customer Validation
  Flow cytometry analysis of WT and Myo19 KO cells stained with 100 nM TMRM for 20 min. 5 μM FCCP treatment for 10 min was used as positive.