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Estée Lauder Advanced Night Repair Synchronized Multi-Recovery Complex Serum Versus Some By Mi Retinol Intense Reactivating Serum

Estée Lauder Advanced Night Repair Synchronized Multi-Recovery Complex Serum Versus Some By Mi Retinol Intense Reactivating Serum This barrier-repair serum is formulated around Bifida Ferment Lysate and Sodium Hyaluronate to strengthen the skin barrier and sof

Written by Peptide Therapy Guide Editorial Team
For education only

This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.

Estée Lauder Advanced Night Repair Synchronized Multi-Recovery Complex Serum Versus Some By Mi Retinol Intense Reactivating Serum

This barrier-repair serum is formulated around Bifida Ferment Lysate and Sodium Hyaluronate to strengthen the skin barrier and soften the look of wrinkles.

This anti-aging serum is formulated around Retinol and Bakuchiol to soften the look of wrinkles and refine skin texture.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Bifida Ferment Lysate

PEG-8

Propanediol

Bis-PEG-18 Methyl Ether Dimethyl Silane

Methyl Gluceth-20

Glycereth-26

PEG-75

Butylene Glycol

Adansonia Digitata Seed Extract

Tripeptide-32

Sodium Hyaluronate

Faex Extract

Lactobacillus Ferment

Cola Acuminata Seed Extract

Anthemis Nobilis Flower Extract

Hydrolyzed Algin

Pantethine

Caffeine

Lecithin

Sodium Rna

Bisabolol

Squalane

Glycerin

Oleth-3 Phosphate

Caprylyl Glycol

Oleth-3

Oleth-5

Choleth-24

Hydrogenated Lecithin

Jojoba Wax PEG-120 Esters

Ceteth-24

Tocopheryl Acetate

Carbomer

Triethanolamine

Tetrasodium EDTA

BHT

Xanthan Gum

Potassium Sorbate

Disodium EDTA

Phenoxyethanol

CI 14700

CI 19140

Water, Bifida Ferment Lysate, PEG-8, Propanediol, Bis-PEG-18 Methyl Ether Dimethyl Silane, Methyl Gluceth-20, Glycereth-26, PEG-75, Butylene Glycol, Adansonia Digitata Seed Extract, Tripeptide-32, Sodium Hyaluronate, Faex Extract, Lactobacillus Ferment, Cola Acuminata Seed Extract, Anthemis Nobilis Flower Extract, Hydrolyzed Algin, Pantethine, Caffeine, Lecithin, Sodium Rna, Bisabolol, Squalane, Glycerin, Oleth-3 Phosphate, Caprylyl Glycol, Oleth-3, Oleth-5, Choleth-24, Hydrogenated Lecithin, Jojoba Wax PEG-120 Esters, Ceteth-24, Tocopheryl Acetate, Carbomer, Triethanolamine, Tetrasodium EDTA, BHT, Xanthan Gum, Potassium Sorbate, Disodium EDTA, Phenoxyethanol, CI 14700, CI 19140

Cyclohexasiloxane

Dicaprylyl Carbonate

Methylpropanediol

1,2-Hexanediol

Niacinamide

Hydrogenated Poly(C6-14 Olefin)

Panthenol

Piper Methysticum Leaf/Root/Stem Extract

Centella Asiatica Extract

Panax Ginseng Berry Extract

Glycyrrhiza Glabra Root Extract

Ficus Carica Fruit Extract

Centella Asiatica Leaf Extract

Centella Asiatica Root Extract

Melaleuca Alternifolia Leaf Extract

Artemisia Capillaris Extract

Eclipta Prostrata Extract

Melia Azadirachta Leaf Extract

Elaeis Guineensis Oil

Glyceryl Stearate

Bakuchiol

Palmitic Acid

Sodium Polyacrylate

Stearic Acid

Retinol 0.1%

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Dipotassium Glycyrrhizate

Adenosine

Tromethamine

Polyquaternium-51

Beta-Glucan

Cetyl Alcohol

Collagen

Myristic Acid

BHA

Leuconostoc/Radish Root Ferment Filtrate

Tocopherol

Ceramide NP

Saccharomyces Ferment

Retinal

Asiaticoside

Glyceryl Polymethacrylate

Madecassoside

Propylene Glycol

Polyglyceryl-10 Oleate

Glycolipids

Glycine Soja Peptide

Resveratrol

Sucrose Distearate

Asiatic Acid

Madecassic Acid

Palmitoyl Tripeptide-1

Moringa Oleifera Seed Oil

PEG-100 Stearate

Polysorbate 20

Parfum

Ethylhexylglycerin

Water, Cyclohexasiloxane, Dicaprylyl Carbonate, Glycerin, Methylpropanediol, 1,2-Hexanediol, Niacinamide, Hydrogenated Poly(C6-14 Olefin), Panthenol, Tocopheryl Acetate, Piper Methysticum Leaf/Root/Stem Extract, Centella Asiatica Extract, Panax Ginseng Berry Extract, Glycyrrhiza Glabra Root Extract, Ficus Carica Fruit Extract, Centella Asiatica Leaf Extract, Centella Asiatica Root Extract, Melaleuca Alternifolia Leaf Extract, Artemisia Capillaris Extract, Eclipta Prostrata Extract, Melia Azadirachta Leaf Extract, Elaeis Guineensis Oil, Hydrogenated Lecithin, Glyceryl Stearate, Bakuchiol, Palmitic Acid, Sodium Polyacrylate, Stearic Acid, Xanthan Gum, Retinol 0.1%, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Butylene Glycol, Dipotassium Glycyrrhizate, Adenosine, Tromethamine, Polyquaternium-51, Beta-Glucan, Cetyl Alcohol, BHT, Collagen, Myristic Acid, BHA, Leuconostoc/Radish Root Ferment Filtrate, Tocopherol, Bifida Ferment Lysate, Ceramide NP, Saccharomyces Ferment, Retinal, Asiaticoside, Glyceryl Polymethacrylate, Madecassoside, Propylene Glycol, Polyglyceryl-10 Oleate, Glycolipids, Glycine Soja Peptide, Resveratrol, Sucrose Distearate, Asiatic Acid, Madecassic Acid, Palmitoyl Tripeptide-1, Moringa Oleifera Seed Oil, PEG-100 Stearate, Polysorbate 20, Parfum, Ethylhexylglycerin

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

BHT is a synthetic antioxidant and preservative.

As an antioxidant, it helps your body fight off free-radicals. Free-radicals are molecules that may damage your skin cells.

As a preservative, it is used to stabilize products and prevent them from degrading. Specifically, BHT prevents degradation from oxidation.

The concerns related to BHT come from oral studies; this ingredient is currently allowed for use by both the FDA and EU.

However, it was recently restricted for use in the UK as of April 2024.

Bifida Ferment Lysate is a postbiotic ingredient made by fermenting Bifidobacterium to extract a nutrient-rich mix of peptides, amino acids, vitamins, organic acids, and polysaccharides.

These components are basically the building blocks that your skin already uses to stay hydrated, repair itself, and maintain its barrier. That's why this ingredient helps your skin hold onto moisture and stay resilient against irritation.

One in-vitro study found that this ingredient tells your skin cells to produce more of the proteins (filaggrin, loricrin, and involucrin) for building a strong and healthy barrier. This study also found this ingredient to be a solid antioxidant that helped neutralize damage against UV and pollution.

A study with people from 2010 found that sensitive, reactive skin using a cream with 10% of this ingredient for a month became noticeably less dry, less reactive, and harder to irritate compared to the group using a plain cream.

In short, this ingredient is a well-tolerated ingredient that can help with barrier repair, antioxidant protection, and calming reactive skin.

This ingredient is generally considered fungal acne (Malassezia) safe; Bifidobacterium is a bacterium, not a yeast or fungus.

The fungal acne concern with fermented ingredients mainly applies to yeast-derived ferments like Saccharomyces and Galactomyces, because those are in the same kingdom as Malassezia and could theoretically contain residual compounds that feed it.

Bifida is a completely different organism, so on its own it doesn't provide a food source for the Malassezia yeast that causes fungal acne.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Hydrogenated Lecithin is a more stable version of lecithin.

It's made by taking lecithin (a phospholipid commonly found in soybeans and egg yolks) and hydrogenating it. This just means the unsaturated fatty acids are turned into saturated ones so they don't go bad as easily.

This ingredient is an emollient, emulsifier, and penetration enhancer. As an emollient, it helps soften and hydrate skin by trapping moisture within. As an emulsifier, it prevents oil and water ingredients from separating.

Hydrogenated Lecithin can form tiny spherical structures made of phospholipid bilayers called liposomes. These liposomes are able to capture compounds inside their structure and deliver them through the skin barrier.

Because phospholipids are a natural component of our cell membranes, this ingredient is inherently compatible with skin.

A 2021 study found lecithin-based surfactants were less harsh and more tolerable comared to Sodium Lauryl Sulfate (SLS).

Tocopheryl Acetate is a stable, shelf-friendly form of vitamin E.

Formulators love it because plain vitamin E oxidizes quickly once it hits air. This acetate version stays stable and resists going off, helping to extend a product's shelf life.

It's actually inactive on its own and works like a slow-release "storage" form; the enzymes in your skin called esterases gradually convert it into active vitamin E over time.

One in vivo study showed 5% of the acetate in the living layer of the epidermis converted to vitamin E after 5 days of application. This study also found the skin gained protection against UV damage even though the conversion was slow and small.

Once converted, vitamin E acts as a skin's main fat-soluble antioxidant that fights free radicals to protect skin from damage.

Topical vitamin E generally boosts the skin's photoprotection, and it reduced UV-damage in animal models.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

Overall, it has a pretty solid safety profile and has been found to be non-irritating and non-comedogenic. Allergic reactions may happen but stay rare due to how widely the ingredient gets used.

The concentration will vary depending on the formula; industry data shows 0.1% in baby lotions, 3% in lipsticks, and 5% in foot powders. You can also find this ingredient at 100% in a pure vitamin E oil.

Most leave-on skincare keeps it at the lower end, often between 0.5-1%.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Xanthan gum is used as a stabilizer and thickener within cosmetic products. It helps give products a sticky, thick feeling - preventing them from being too runny.

On the technical side of things, xanthan gum is a polysaccharide - a combination consisting of multiple sugar molecules bonded together.

Xanthan gum is a pretty common and great ingredient. It is a natural, non-toxic, non-irritating ingredient that is also commonly used in food products.

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Peptide Therapy Guide Editorial Team

Editorial team for Peptide Therapy Guide.

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