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Estée Lauder Advanced Night Repair Synchronized Multi-Recovery Complex Serum Versus SK-II R.N.A. POWER Anti-Aging Face Cream

Estée Lauder Advanced Night Repair Synchronized Multi-Recovery Complex Serum Versus SK-II R.N.A. POWER Anti-Aging Face Cream This barrier-repair serum is formulated around Bifida Ferment Lysate and Sodium Hyaluronate to strengthen the skin barrier and soften t

Written by Peptide Therapy Guide Editorial Team
For education only

This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.

Estée Lauder Advanced Night Repair Synchronized Multi-Recovery Complex Serum Versus SK-II R.N.A. POWER Anti-Aging Face Cream

This barrier-repair serum is formulated around Bifida Ferment Lysate and Sodium Hyaluronate to strengthen the skin barrier and soften the look of wrinkles.

This anti-aging moisturizer is formulated around Galactomyces Ferment Filtrate and Niacinamide to soften the look of wrinkles and strengthen the skin barrier.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Bifida Ferment Lysate

PEG-8

Propanediol

Bis-PEG-18 Methyl Ether Dimethyl Silane

Methyl Gluceth-20

Glycereth-26

PEG-75

Butylene Glycol

Adansonia Digitata Seed Extract

Tripeptide-32

Sodium Hyaluronate

Faex Extract

Lactobacillus Ferment

Cola Acuminata Seed Extract

Anthemis Nobilis Flower Extract

Hydrolyzed Algin

Pantethine

Caffeine

Lecithin

Sodium Rna

Bisabolol

Squalane

Glycerin

Oleth-3 Phosphate

Caprylyl Glycol

Oleth-3

Oleth-5

Choleth-24

Hydrogenated Lecithin

Jojoba Wax PEG-120 Esters

Ceteth-24

Tocopheryl Acetate

Carbomer

Triethanolamine

Tetrasodium EDTA

BHT

Xanthan Gum

Potassium Sorbate

Disodium EDTA

Phenoxyethanol

CI 14700

CI 19140

Water, Bifida Ferment Lysate, PEG-8, Propanediol, Bis-PEG-18 Methyl Ether Dimethyl Silane, Methyl Gluceth-20, Glycereth-26, PEG-75, Butylene Glycol, Adansonia Digitata Seed Extract, Tripeptide-32, Sodium Hyaluronate, Faex Extract, Lactobacillus Ferment, Cola Acuminata Seed Extract, Anthemis Nobilis Flower Extract, Hydrolyzed Algin, Pantethine, Caffeine, Lecithin, Sodium Rna, Bisabolol, Squalane, Glycerin, Oleth-3 Phosphate, Caprylyl Glycol, Oleth-3, Oleth-5, Choleth-24, Hydrogenated Lecithin, Jojoba Wax PEG-120 Esters, Ceteth-24, Tocopheryl Acetate, Carbomer, Triethanolamine, Tetrasodium EDTA, BHT, Xanthan Gum, Potassium Sorbate, Disodium EDTA, Phenoxyethanol, CI 14700, CI 19140

Galactomyces Ferment Filtrate

Isohexadecane

Niacinamide

Isopropyl Isostearate

Butyrospermum Parkii Butter

Caprylic/Capric Triglyceride

Pentylene Glycol

Dimethicone

Phytosteryl/Behenyl/Octyldodecyl Lauroyl Glutamate

Vinyl Dimethicone/Methicone Silsesquioxane Crosspolymer

Stearyl Alcohol

Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer

Cetyl Alcohol

Behenyl Alcohol

Panthenol

Benzyl Alcohol

Dimethiconol

Cetearyl Alcohol

Cetearyl Glucoside

Methylparaben

PEG-100 Stearate

Polymethylsilsesquioxane

Polysorbate 80

Stearic Acid

Propylparaben

Sodium PEG-7 Olive Oil Carboxylate

Ethylparaben

Sorbitan Oleate

Chlorella Vulgaris Extract

PEG-7 Glyceryl Cocoate

Sodium Hydroxide

Parfum

Acanthopanax Senticosus Root Extract

Hydrolyzed Soy Protein

Cynara Scolymus Leaf Extract

Polyquaternium-7

Hydrolyzed Yeast Protein

Palmitoyl Pentapeptide-4

Methylsilanol Tri-PEG-8 Glyceryl Cocoate

Methicone

CI 77891

CI 77492

Water, Glycerin, Galactomyces Ferment Filtrate, Isohexadecane, Niacinamide, Isopropyl Isostearate, Butylene Glycol, Butyrospermum Parkii Butter, Caprylic/Capric Triglyceride, Pentylene Glycol, Dimethicone, Phytosteryl/Behenyl/Octyldodecyl Lauroyl Glutamate, Vinyl Dimethicone/Methicone Silsesquioxane Crosspolymer, Stearyl Alcohol, Sodium Acrylate/Sodium Acryloyldimethyl Taurate Copolymer, Cetyl Alcohol, Behenyl Alcohol, Panthenol, Tocopheryl Acetate, Benzyl Alcohol, Dimethiconol, Cetearyl Alcohol, Cetearyl Glucoside, Methylparaben, PEG-100 Stearate, Polymethylsilsesquioxane, Polysorbate 80, Stearic Acid, Disodium EDTA, Propylparaben, Sodium PEG-7 Olive Oil Carboxylate, Ethylparaben, Sorbitan Oleate, Chlorella Vulgaris Extract, PEG-7 Glyceryl Cocoate, Sodium Hydroxide, Parfum, Acanthopanax Senticosus Root Extract, Hydrolyzed Soy Protein, Cynara Scolymus Leaf Extract, Polyquaternium-7, Hydrolyzed Yeast Protein, Palmitoyl Pentapeptide-4, Methylsilanol Tri-PEG-8 Glyceryl Cocoate, Methicone, CI 77891, CI 77492

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.

This ingredient mainly works behind the scenes and helps with:

On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.

One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).

Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.

You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Tocopheryl Acetate is a stable, shelf-friendly form of vitamin E.

Formulators love it because plain vitamin E oxidizes quickly once it hits air. This acetate version stays stable and resists going off, helping to extend a product's shelf life.

It's actually inactive on its own and works like a slow-release "storage" form; the enzymes in your skin called esterases gradually convert it into active vitamin E over time.

One in vivo study showed 5% of the acetate in the living layer of the epidermis converted to vitamin E after 5 days of application. This study also found the skin gained protection against UV damage even though the conversion was slow and small.

Once converted, vitamin E acts as a skin's main fat-soluble antioxidant that fights free radicals to protect skin from damage.

Topical vitamin E generally boosts the skin's photoprotection, and it reduced UV-damage in animal models.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

Overall, it has a pretty solid safety profile and has been found to be non-irritating and non-comedogenic. Allergic reactions may happen but stay rare due to how widely the ingredient gets used.

The concentration will vary depending on the formula; industry data shows 0.1% in baby lotions, 3% in lipsticks, and 5% in foot powders. You can also find this ingredient at 100% in a pure vitamin E oil.

Most leave-on skincare keeps it at the lower end, often between 0.5-1%.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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About the author

Peptide Therapy Guide Editorial Team

Editorial team for Peptide Therapy Guide.

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