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Estée Lauder Advanced Night Repair Eye Supercharged Complex Versus Estée Lauder Revitalizing Supreme + Night

Estée Lauder Advanced Night Repair Eye Supercharged Complex Versus Estée Lauder Revitalizing Supreme + Night This barrier-repair eye moisturizer is formulated around Bifida Ferment Lysate and Caffeine to strengthen the skin barrier and soften the look of wrink

Written by Peptide Therapy Guide Editorial Team
For education only

This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.

Estée Lauder Advanced Night Repair Eye Supercharged Complex Versus Estée Lauder Revitalizing Supreme + Night

This barrier-repair eye moisturizer is formulated around Bifida Ferment Lysate and Caffeine to strengthen the skin barrier and soften the look of wrinkles.

This anti-aging night moisturizer is formulated around Niacinamide and Moringa Oleifera Seed Extract to soften the look of wrinkles and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Methyl Trimethicone

Water

Bifida Ferment Lysate

Dimethicone

Dimethicone/Vinyl Dimethicone Crosspolymer

Propanediol

Sucrose

Petrolatum

Polysorbate 40

Trehalose

Algae Extract

Morus Bombycis Root Extract

Scutellaria Baicalensis Root Extract

Lactobacillus Ferment

Triticum Vulgare Germ Extract

Acrylamide/Sodium Acryloyldimethyltaurate Copolymer

Betula Alba Bark Extract

Hydrolyzed Algin

Poria Cocos Sclerotium Extract

Jojoba Alcohol

Ethylhexylglycerin

Glycine Soja Seed Extract

Isopropyl Jojobate

Jojoba Esters

Isohexadecane

Faex Extract

Hydrogenated Lecithin

Hordeum Vulgare Extract

PEG/PPG-18/18 Dimethicone

Cholesterol

Anthemis Nobilis Flower Extract

Tocopheryl Acetate

Sodium Rna

Caffeine

Polysorbate 80

Caprylyl Glycol

Phytosphingosine

Squalane

Potassium Sulfate

Sodium Hyaluronate

Acrylates/C10-30 Alkyl Acrylate Crosspolymer

Tripeptide-32

Butylene Glycol

Tromethamine

Disodium EDTA

BHT

Phenoxyethanol

CI 77491

CI 77492

CI 77499

Methyl Trimethicone, Water, Bifida Ferment Lysate, Dimethicone, Dimethicone/Vinyl Dimethicone Crosspolymer, Propanediol, Sucrose, Petrolatum, Polysorbate 40, Trehalose, Algae Extract, Morus Bombycis Root Extract, Scutellaria Baicalensis Root Extract, Lactobacillus Ferment, Triticum Vulgare Germ Extract, Acrylamide/Sodium Acryloyldimethyltaurate Copolymer, Betula Alba Bark Extract, Hydrolyzed Algin, Poria Cocos Sclerotium Extract, Jojoba Alcohol, Ethylhexylglycerin, Glycine Soja Seed Extract, Isopropyl Jojobate, Jojoba Esters, Isohexadecane, Faex Extract, Hydrogenated Lecithin, Hordeum Vulgare Extract, PEG/PPG-18/18 Dimethicone, Cholesterol, Anthemis Nobilis Flower Extract, Tocopheryl Acetate, Sodium Rna, Caffeine, Polysorbate 80, Caprylyl Glycol, Phytosphingosine, Squalane, Potassium Sulfate, Sodium Hyaluronate, Acrylates/C10-30 Alkyl Acrylate Crosspolymer, Tripeptide-32, Butylene Glycol, Tromethamine, Disodium EDTA, BHT, Phenoxyethanol, CI 77491, CI 77492, CI 77499

Glycine Soja Oil

Caprylic/Capric/Myristic/Stearic Triglyceride

Glycerin

Prunus Amygdalus Dulcis Oil

Stearyl Alcohol

Steareth-2

Cocos Nucifera Oil

Vitis Vinifera Seed Oil

Glyceryl Stearate

Niacinamide

Steareth-21

Moringa Oleifera Seed Extract

Limonium Vulgare Flower/Leaf/Stem Extract

Acetyl Hexapeptide-8

Laminaria Digitata Extract

Whey Protein

Acetyl Glucosamine

Opuntia Tuna Fruit Extract

Citrullus Lanatus Fruit Extract

Persea Gratissima Oil

Mangifera Indica Seed Oil

Aminopropyl Ascorbyl Phosphate

Cucumis Sativus Fruit Extract

Pyrus Malus Fruit Extract

Narcissus Tazetta Bulb Extract

Sigesbeckia Orientalis Extract

Butyrospermum Parkii Butter

Lens Esculenta Fruit Extract

Silybum Marianum Seed Oil

Limnanthes Alba Seed Oil

Simmondsia Chinensis Seed Oil

Macadamia Integrifolia Seed Oil

Olea Europaea Fruit Oil

Dextrin Palmitate

Sodium Hydroxide

Carbomer

Behenyl Alcohol

Hydroxyethyl Urea

Propylene Glycol Dicaprate

Isoceteth-20

Lactoperoxidase

Helianthus Annuus Seedcake

Sodium Polyaspartate

Sorbitol

Glucose

Cetyl Alcohol

Myristyl Alcohol

Sodium Lactate

Citric Acid

Sodium PCA

Glucose Oxidase

Potassium Phosphate

Sodium Chloride

Parfum

Potassium Sorbate

Sodium Benzoate

CI 19140

CI 14700

Water, Glycine Soja Oil, Caprylic/Capric/Myristic/Stearic Triglyceride, Glycerin, Prunus Amygdalus Dulcis Oil, Dimethicone, Stearyl Alcohol, Butylene Glycol, Steareth-2, Cocos Nucifera Oil, Vitis Vinifera Seed Oil, Glyceryl Stearate, Niacinamide, Propanediol, Steareth-21, Moringa Oleifera Seed Extract, Limonium Vulgare Flower/Leaf/Stem Extract, Sodium Hyaluronate, Acetyl Hexapeptide-8, Laminaria Digitata Extract, Whey Protein, Acetyl Glucosamine, Opuntia Tuna Fruit Extract, Tocopheryl Acetate, Citrullus Lanatus Fruit Extract, Persea Gratissima Oil, Mangifera Indica Seed Oil, Aminopropyl Ascorbyl Phosphate, Algae Extract, Caffeine, Cucumis Sativus Fruit Extract, Pyrus Malus Fruit Extract, Narcissus Tazetta Bulb Extract, Sigesbeckia Orientalis Extract, Butyrospermum Parkii Butter, Lens Esculenta Fruit Extract, Silybum Marianum Seed Oil, Limnanthes Alba Seed Oil, Hordeum Vulgare Extract, Simmondsia Chinensis Seed Oil, Macadamia Integrifolia Seed Oil, Olea Europaea Fruit Oil, Dextrin Palmitate, Sodium Hydroxide, Carbomer, Behenyl Alcohol, Caprylyl Glycol, Hydroxyethyl Urea, Propylene Glycol Dicaprate, Cholesterol, Isoceteth-20, Lactoperoxidase, Helianthus Annuus Seedcake, Sodium Polyaspartate, Sorbitol, Glucose, Cetyl Alcohol, Myristyl Alcohol, Sodium Lactate, Citric Acid, Sodium PCA, Glucose Oxidase, Potassium Phosphate, Sodium Chloride, Parfum, Disodium EDTA, BHT, Potassium Sorbate, Sodium Benzoate, Phenoxyethanol, CI 19140, CI 14700, CI 77491, CI 77492

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Algae Extract is a confusing name. This is because algae is an informal term for a group of 30,000 aquatic organisms that can photosynthesize.

The term 'algae extract' can refer to any one, or a blend of, the 30,000 types.

Algae is rich in antioxidants. Antioxidants help fight free-radicals. Free-radicals are molecules that may damage your skin cells, such as pollution.

Algae can also help with soothing and hydrating skin.

Many different types of algae have different benefits.

BHT is a synthetic antioxidant and preservative.

As an antioxidant, it helps your body fight off free-radicals. Free-radicals are molecules that may damage your skin cells.

As a preservative, it is used to stabilize products and prevent them from degrading. Specifically, BHT prevents degradation from oxidation.

The concerns related to BHT come from oral studies; this ingredient is currently allowed for use by both the FDA and EU.

However, it was recently restricted for use in the UK as of April 2024.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Caffeine is a naturally occurring plant compound found in coffee beans, tea leaves, cocoa pods, and guarana.

As an antioxidant, caffeine protects your skin from free radical damage caused by UV exposure and envionrmnetal stressors.

Early research also shows that caffeine can help calm redness, soothe irritated skin, and support hair growth by stimulating microcirculation in the scalp.

You might have seen eye creams marketing caffeine as a depuffing ingredient. This is because it is a vasoconstrictor meaning it can temporarily constrict blood vessels, though clinical evidence for this specific use is still limited.

Most skincare products contain this ingredient at concentrations between 1-6%. It is able to penetrate skin easily regardless of skin type or thickness.

Just so you know, a very small number of case reports describe caffeine-induced allergy. This ingredient is generally well-tolerated, non-irritating, and non-sensitizing for the majority of people.

Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.

Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Cholesterol is a lipid that is naturally found in human skin and is one of the three key components of your skin barrier. In skincare, it is an emollient and barrier-repairing ingredient.

It works by fitting directly into the lipid layers of skin to help restore structure and reduce transepidermal water loss (TEWL).

This is a great ingredient for dry, compromised, or aging skin; our skin starts to produce less cholesterol with age.

Research shows cholesterol works best in combination with ceramides and fatty acids, the other two major components in your skin barrier.

Cholesterol is also a well-establish penetration enhancer and can help other actives absorb more effectively.

Cosmetic-grade cholesterol is usually derived from lanolin but plant and synthetic options also exist. We recommend reaching out to the brand if you have questions about their source of cholesterol.

Ci 77491 is also hydrated iron III oxide. It's sole purpose is to give a red/pink hue to products.

Iron III oxides are classified as inorganic chemicals for coloring.

Synthetically created Ci 77491 is considered safer than those naturally found. This is because the synthetically created version may contain less impurities. Iron oxides are generally non-toxic and non-allergenic.

CI 77492 is also hydrated iron III oxide. It's sole purpose is to give a yellow hue to products.

Synthetically created CI 77492 is considered safer than those naturally found. This is because the synthetically created version may contain less impurities. Iron oxides are generally non-toxic and non-allergenic.

Dimethicone is a type of synthetic silicone created from natural materials such as quartz. It is also known as polydimethylsiloxane.

What it does:

Dimethicone comes in different viscosities:

Depending on the viscosity, dimethicone has different properties.

Ingredients lists don't always show which type is used, so we recommend reaching out to the brand if you have questions about the viscosity.

This ingredient is unlikely to cause irritation because it does not get absorbed into skin. However, people with silicone allergies should be careful about using this ingredient.

Note: Dimethicone may contribute to pilling. This is because it is not oil or water soluble, so pilling may occur when layered with products. When mixed with heavy oils in a formula, the outcome is also quite greasy.

Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.

This ingredient mainly works behind the scenes and helps with:

On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.

One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).

Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.

You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.

Hordeum Vulgare Extract is an extract of barley, the same grain used in beer and bread.

In skincare, it is a skin conditioning and hydrating agent. This ingredient contains polyphenols, vitamin E, and trace minerals like zinc, copper, and selenium that help neutralize free radicals behind oxidative skin stress.

Lab studies on human skin cells show it can support the skin barrier, boost cell survival, and speed repair after UV exposure.

The Cosmetic Ingredient Review Expert Panel has reviewed 16 barley-derived ingredients and concluded they're safe as used with the highest reported use concentration being 1.5% (in leave-on body/hand products).

Patch testing has also found it not to be a skin irritant or sensitizer at cosmetic levels.

However, barley is a recognized food allergen so people with a known barley/grain allergy should approach it cautiously.

Note: This ingredient is not gluten-free for those avoiding gluten for skin-contact reasons.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Propanediol is an all-star ingredient. It softens, hydrates, and smooths the skin.

It’s often used to:

Propanediol is not likely to cause sensitivity and considered safe to use. It is derived from corn or petroleum with a clear color and no scent.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Tocopheryl Acetate is a stable, shelf-friendly form of vitamin E.

Formulators love it because plain vitamin E oxidizes quickly once it hits air. This acetate version stays stable and resists going off, helping to extend a product's shelf life.

It's actually inactive on its own and works like a slow-release "storage" form; the enzymes in your skin called esterases gradually convert it into active vitamin E over time.

One in vivo study showed 5% of the acetate in the living layer of the epidermis converted to vitamin E after 5 days of application. This study also found the skin gained protection against UV damage even though the conversion was slow and small.

Once converted, vitamin E acts as a skin's main fat-soluble antioxidant that fights free radicals to protect skin from damage.

Topical vitamin E generally boosts the skin's photoprotection, and it reduced UV-damage in animal models.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

Overall, it has a pretty solid safety profile and has been found to be non-irritating and non-comedogenic. Allergic reactions may happen but stay rare due to how widely the ingredient gets used.

The concentration will vary depending on the formula; industry data shows 0.1% in baby lotions, 3% in lipsticks, and 5% in foot powders. You can also find this ingredient at 100% in a pure vitamin E oil.

Most leave-on skincare keeps it at the lower end, often between 0.5-1%.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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Peptide Therapy Guide Editorial Team

Editorial team for Peptide Therapy Guide.

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