Dermaseptin-PS1 peptide

Product Information

• Product Name

  Dermaseptin-PS1 peptide

• Documents
• Sequence Shortening

  H-ALWKTMLKKLGTVALHAGKAALGAVADTISQ-NH2

• Sequence

  H-Ala-Leu-Trp-Lys-Thr-Met-Leu-Lys-Lys-Leu-Gly-Thr-Val-Ala-Leu-His-Ala-Gly-Lys-Ala-Ala-Leu-Gly-Ala-Val-Ala-Asp-Thr-Ile-Ser-Gln-NH2

• Length (aa)

  31

• Peptide Purity (HPLC)

  95.2%

• Molecular Formula

  C143H244N40O38S

• Molecular Weight

  3163.76

• Source

  Synthetic

• Form

  Powder

• Description

  Dermaseptin‐PS1 is a novel antimicrobial peptide isolated from P. sauvagei. Dermaseptin‐PS1 exhibited moderate antimicrobial activity against typical strains. Dermaseptin‐PS1 displayed antiproliferative activity in glioblastoma U‐251 MG cells. Dermaseptin‐PS1 induced U‐251 MG cell death at 10−6 M via induction of apoptosis. Dermaseptin‐PS1 induced U‐251 MG cell apoptosis through intrinsic cascade.

• Storage Guidelines

  Normally, this peptide will be delivered in lyophilized form and should be stored in a freezer at or below -20 °C. For more details, please refer to the manual: Handling and Storage of Synthetic Peptides

• References
  • Wu Z, Wu Y, Fischer J, Bartels J, Schru00f6der JM, Meyer-Hoffert U. Skin-Derived SPINK9 Kills Escherichia coli. J Invest Dermatol. 2019;139(5):1135-1142
• About TFA salt

  Trifluoroacetic acid (TFA) is a common counterion from the purification process using High-Performance Liquid Chromatography (HPLC). The presence of TFA can affect the peptide's net weight, appearance, and solubility.

  Impact on Net Weight: The TFA salt contributes to the total mass of the product. In most cases, the peptide content constitutes >80% of the total weight, with TFA accounting for the remainder.

  Solubility: TFA salts generally enhance the solubility of peptides in aqueous solutions.

  In Biological Assays: For most standard in vitro assays, the residual TFA levels do not cause interference. However, for highly sensitive cellular or biochemical studies, please be aware of its presence.

• Molar Concentration Calculator

• Dilution Calculator

• Percent Concentration Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Peptide Property

• Analysed Sequence:A
• Chemical Formula:A
• Sequence length:A
• Extinction coefficient:A M-1cm-1
• GRAVY:A
• Mw average:A
• Theoretical pI:A
• Data Source:Peptide Property Calculator

GRAVY = grand average of hydropathy

X: Hydrophobic uncharged residues, like F I L M V W A and P

X: Basic residues, like R K H

X: Acidic residues, like D E

X: Polar uncharged residues, like G S T C N Q and Y

• Peptide Services: NovoPro's peptide synthesis services include standard chemical peptide synthesis, peptide modification, peptide libraries, and recombinant peptide expression.

• Standard Peptide Synthesis: NovoPro offers quality peptides at the most competitive prices in the industry, starting at $3.20 per amino acid. NovoPro provides PepBox – Automatic Quote Tool for online price calculation.

• Peptide Modifications: NovoPro offers a wide range of peptide modification services including isotope labeling (2H, 15N, and 13C), multiple disulfide bonds, multiple phosphorylations, KLH, BSA, ovalbumin, amidation, acetylation, biotin, FITC, etc.