Independent education resourceInformation here does not replace care from a qualified health professional.
Peptide Therapy GuideClear peptide education

Educational guide

Biossance Squalane + Omega Repair Cream Versus Three Ships Beauty Restore Ceramides + Gotu Kola Barrier Repair Cream

Biossance Squalane + Omega Repair Cream Versus Three Ships Beauty Restore Ceramides + Gotu Kola Barrier Repair Cream This barrier-repair moisturizer is formulated around Squalane and Ceramide NP to strengthen the skin barrier and hydrate skin. What's inside Ke

Written by Peptide Therapy Guide Editorial Team
For education only

This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.

Biossance Squalane + Omega Repair Cream Versus Three Ships Beauty Restore Ceramides + Gotu Kola Barrier Repair Cream

This barrier-repair moisturizer is formulated around Squalane and Ceramide NP to strengthen the skin barrier and hydrate skin.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Squalane

Glycerin

Caprylic/Capric Triglyceride

Isoamyl Laurate

Butyrospermum Parkii Butter

Sorbitan Olivate

Cetearyl Olivate

Ceramide NP

Jojoba Esters

Sodium Hyaluronate

Euterpe Oleracea Sterols

Linoleic Acid

Oleic Acid

Linolenic Acid

Ethyl Linoleate

Tocopherol

Isoamyl Cocoate

Cetyl Palmitate

Sorbitan Palmitate

Cetearyl Alcohol

Ethylhexylglycerin

Carbomer

Sodium Hydroxide

Phenoxyethanol

Sodium Gluconate

Water, Squalane, Glycerin, Caprylic/Capric Triglyceride, Isoamyl Laurate, Butyrospermum Parkii Butter, Sorbitan Olivate, Cetearyl Olivate, Ceramide NP, Jojoba Esters, Sodium Hyaluronate, Euterpe Oleracea Sterols, Linoleic Acid, Oleic Acid, Linolenic Acid, Ethyl Linoleate, Tocopherol, Isoamyl Cocoate, Cetyl Palmitate, Sorbitan Palmitate, Cetearyl Alcohol, Ethylhexylglycerin, Carbomer, Sodium Hydroxide, Phenoxyethanol, Sodium Gluconate

Glyceryl Stearate

Centella Asiatica Leaf Extract

Helianthus Annuus Seed Wax

Sodium Stearoyl Glutamate

Polyglycerin-3

Xanthan Gum

Caprylhydroxamic Acid

Glyceryl Caprylate

Water, Squalane, Cetearyl Alcohol, Glycerin, Caprylic/Capric Triglyceride, Glyceryl Stearate, Jojoba Esters, Ceramide NP, Centella Asiatica Leaf Extract, Helianthus Annuus Seed Wax, Sodium Stearoyl Glutamate, Polyglycerin-3, Xanthan Gum, Tocopherol, Caprylhydroxamic Acid, Glyceryl Caprylate

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Caprylic/Capric Triglyceride (aka MCT Oil) is a lightweight emollient, solvent, and texture enhancer. It is considered a skin-softener by helping to prevent moisture loss.

Though it behaves like an oil, it is not technically one due to its chemical composition. One perk of this ingredient is that it is very stable, resistant to oxidation, and unlikely to go rancid.

In practice, that translates to a long shelf life and a consistently elegant skin feel.

While there is an assumption Caprylic Triglyceride can clog pores due to it being derived from coconut oil, there is no research supporting this. Just patch test if you have concerns.

Fractionated coconut oil and MCT Oil are both listed as Caprylic/Capric Triglyceride according to INCI. This is because INCI names are based on the ingredient’s final chemical composition and not its marketing name or source.

This ingredient is treated as the gold standard fungal acne safe oil. Even though it is coconut derived, the problematic lauric acid is stripped out.

This leaves just caprylic (C8) and capric (C10) acid. These chain lengths actually trend antifungal; a 2020 study found caprylic acid was enough to disrupt Malassezia furfur cell membrane, with a caprylic acid derivative damaging membrane structures at concentrations as low as 0.2%.

Ceramide NP (formerly known as Ceramide 3) is one of the skin's naturally occurring lipids.

Since ceramides are the major lipid components of the skin, they are crucial for maintaining skin barrier and hydration. Ceramide NP most closely mirrors the dominant kind in human skin amongst ceramide subtypes.

This ceramide works by slotting into gaps within the stratum corneum's lipid matrix to limit trans-epidermal water loss (TEWL) and shield the skin against external irritants.

A study with 312 patients found that using a ceramide-containing routine for 4 weeks reduced the severity of atopic dermatitis by over 61%.

Another clinical study in subjects aged 60 and older found that a ceramide body wash and moisturizer improved skin dryness and itchy skin in 15 days.

Overall, ceramides are considered non-irritating and safety tests have found little to no observable adverse effects from using this ingredient.

Ceramide NP is usually sourced from plants (like soybean or rice bran), or produced synthetically.

Cetearyl alcohol is a waxy mixture of two fatty alcohols: cetyl alcohol and stearyl alcohol. It is an emollient and emulsifier.

Despite having "alcohol" in its name, it has nothing to do with drying solvent alcohols; the FDA also allows "alcohol-free" products to contain fatty alcohols like this ingredient.

It plays several roles in a formula:

Typical use levels for this ingredient sit around 1-10% and the Cosmetic Ingredient Review Expert Panel has affirmed safety at concentrations up to 25% in leave-on products.

Multiple assessments have found it to be non-irritating and non-sensitizing to most people.

However, there have been some cases of allergic contact dermatitis in patients with chronically compromised skin barriers.

Cetearyl alcohol has a comedogenic rating of 2 and irritancy rating of 1. Both of these numbers come from the 1989 study that used rabbit ears; a "2" means mildly comedogenic and a "1" means low irritancy.

Here's the catch: rabbit skin is more sensitive than human skin and throws a lot of false positives. A 1996 reappraisal found that ingredients rated 1-2 in the rabbit ear tests are generally safe for humans.

Remember comedogenic ratings are unable to assess the entire formula of a product or how it will react on your skin. Just be sure to patch test if you are unsure about certain ingredients.

This ingredient is not fungal acne safe. Cetearyl alcohol is a fatty alcohol with chain lengths that fall within the range that Malassezia can metabolize.

A 2019 study has also observed Malassezia growth in the presence of this ingredient, confirming it to be not-fungal acne safe.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Jojoba Esters is a wax created from Jojoba oil. It is an emollient and film-forming ingredient. In bead form, it is an exfoliator.

This ingredient has high oxidative stability, meaning it doesn't break down when exposed to oxygen.

Its similarity to our skin's natural oils makes it a great emollient. Emollients help soften and soothe our skin by creating a barrier on top. This barrier helps trap moisture in, keeping skin hydrated.

It is created using either the hydrogenation or transesterification processes on jojoba oil.

Squalane is the hydrogenated and shelf-stable form of squalene (a lipid that naturally occurs in human sebum).

It is an emollient and skin conditioning agent that is able to integrate seamlessly into the skin's lipid barrier without clogging pores.

This is due to how structurally similar it is to what your skin already produces.

Though it is mostly an emollient that helps soften and hydrate skin, it also has some humectant and occlusive action. Humectants help the skin retain moisture while occlusives seal it in, making squalane a triple-threat moisturizer.

Research shows it has antioxidant capabilities that help protect against stressors like UV exposure, specifically UVA induced oxidative stress. This study also found that it supports collagen biosynthesis in human dermal fibroblasts.

No clinical study has reported significant adverse effects and irritation reactions are very rare from this ingredient (even at 100% concentration).

Overall, it's a fantastic ingredient for hydration and is suitable for all skin types.

This depends on the source. Squalane can be derived from both plants and animals. Most squalane used in skincare comes from plants.

Please note: the source of squalane is only known if disclosed by the brand. We recommend reaching out to the brand if you have any questions about their squalane.

Read more about squalene with an "e".

Though squalane is often called an oil, it’s technically not one. It is a hydrocarbon, meaning it is only made of carbon and hydrogen. True oils are triglycerides and made of fatty acids and glycerol.

The term “oil-free” isn’t regulated so companies can define it however they want. Some exclude all oils, while others just avoid mineral oil or comedogenic oils.

Squalane has a comedogenic rating of 1 from the original 1972 study that tested raw ingredients under occlusion on rabbit ears. This system is not standardized or peer-reviewed, and using the raw ingredients is very different from how diluted cosmetic formulations are used on human skin.

A comedogenic rating of 1 means it is "unlikely to clog pores" according to the original rating system.

The overall formula of a product matters more than the individual ingredients on whether or not it will cause clogged pores.

Tocopherol is a fat-soluble antioxidant known as Vitamin E.

You'll find this ingredient in the vast majority of skincare (for good reason). It works to neutralize free radicals, or unstable molecules generated by UV exposure, pollution, and other environmental stressors, before they can cause oxidative damage to your skin cells.

Topically applied tocopherol has been shown to protect against UV damage by ramping up the skin's own natural defense enzymes.

It also acts as a skin conditioning agent; some studies show that regular topical use can improve the skin's water-binding capacity over 2-4 weeks.

This ingredient is especially loved for being a team player. When combined with Vitamin C, the photoprotective effect of both ingredients roughly doubles and the combo also helps reduce UV-induced DNA damage.

This ingredient has some brightening potential but it's more of a prevention ingredient than spot-fader. Cell studies show it can slow down melanin production but it's worth noting that it's not the most powerful brightener out there.

In formulations, it also serves as a stabilizer that helps protect other oxidation-prone ingredients from degrading.

Concentrations usually range from 0.1-1% in most leave-on products.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

Connected reading

Helpful context for this guide

Source-derived material selected through this article’s indexed topics.

P

About the author

Peptide Therapy Guide Editorial Team

Editorial team for Peptide Therapy Guide.

View all articles →