Independent education resourceInformation here does not replace care from a qualified health professional.
Peptide Therapy GuideClear peptide education

Educational guide

Biologique Recherche Lotion P50 Versus ZO Skin Health Complexion Renewal Pads

Biologique Recherche Lotion P50 Versus ZO Skin Health Complexion Renewal Pads This smoothing toner is formulated around Gluconolactone and Lactic Acid to refine skin texture and refine the look of pores. This smoothing exfoliating pad uses a pre-saturated pad

Written by Peptide Therapy Guide Editorial Team
For education only

This guide cannot diagnose a condition or recommend a personal treatment plan. Discuss medical questions with a qualified professional.

Biologique Recherche Lotion P50 Versus ZO Skin Health Complexion Renewal Pads

This smoothing toner is formulated around Gluconolactone and Lactic Acid to refine skin texture and refine the look of pores.

This smoothing exfoliating pad uses a pre-saturated pad with Salicylic Acid and Urea to refine skin texture and balance excess oil.

What's inside

Key Ingredients

Benefits

Concerns

Ingredients Side-by-side

Water

Gluconolactone

Lactic Acid

Glycerin

Propylene Glycol

Niacinamide

Citric Acid

Ethoxydiglycol

Magnesium Chloride

Malic Acid

Vinegar

Phytic Acid

Salicylic Acid

Cochlearia Armoracia Root Extract

Arctium Lappa Root Extract

Rumex Acetosa Leaf Extract

Myrtus Communis Extract

Commiphora Myrrha Resin Extract

Allium Cepa Bulb Extract

Thymus Vulgaris Flower/Leaf Oil

Sulfur

Sorbitol

Phenoxyethanol

Sodium Benzoate

Potassium Sorbate

Water, Gluconolactone, Lactic Acid, Glycerin, Propylene Glycol, Niacinamide, Citric Acid, Ethoxydiglycol, Magnesium Chloride, Malic Acid, Vinegar, Phytic Acid, Salicylic Acid, Cochlearia Armoracia Root Extract, Arctium Lappa Root Extract, Rumex Acetosa Leaf Extract, Myrtus Communis Extract, Commiphora Myrrha Resin Extract, Allium Cepa Bulb Extract, Thymus Vulgaris Flower/Leaf Oil, Sulfur, Sorbitol, Phenoxyethanol, Sodium Benzoate, Potassium Sorbate

Alcohol

Urea

Pterocarpus Soyauxii Wood Extract

Phellodendron Amurense Bark Extract

Hordeum Distichon Extract

Camellia Sinensis Leaf Extract

Artemisia Vulgaris Extract

Plantago Lanceolata Leaf Extract

Crithmum Maritimum Extract

Spiraea Ulmaria Extract

Sodium Hydroxide

Glycolic Acid

Butylene Glycol

Sodium Carbonate

Sodium Chloride

Disodium EDTA

T-Butyl Alcohol

Denatonium Benzoate

Parfum

Citronellol

Hexyl Cinnamal

Limonene

Linalool

Water, Alcohol, Propylene Glycol, Salicylic Acid, Urea, Pterocarpus Soyauxii Wood Extract, Phellodendron Amurense Bark Extract, Hordeum Distichon Extract, Camellia Sinensis Leaf Extract, Artemisia Vulgaris Extract, Plantago Lanceolata Leaf Extract, Crithmum Maritimum Extract, Spiraea Ulmaria Extract, Sodium Hydroxide, Glycolic Acid, Butylene Glycol, Sodium Carbonate, Sodium Chloride, Disodium EDTA, T-Butyl Alcohol, Denatonium Benzoate, Phenoxyethanol, Parfum, Citronellol, Hexyl Cinnamal, Limonene, Linalool

Reviews

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

Phenoxyethanol is one of the most widely used preservatives in skincare (and for good reason!).

It has a large spectrum of antimicrobial activity and especially effective bacteria, yeast, and mold while only having a weak effect on your skin's natural microbiome.

On a cellular level, it disrupts the cell membranes of microbes by poking holes that make the cell leak. This shuts down the chemical reactions the microbe needs to make energy so it can no longer survive.

Another perk of this ingredient is that it stays functional across a wide pH range (3-10).

You'll often see it paired with boosters like Ethylhexylglycerin; one study showed that a 1:9 ratio of Ethylhexylglycerin to Phenoxyethanol damages bacterial membranes as effectively as doubling the Phenoxyethanol concentration on its own.

Typical use concentrations range from 0.3-1% depending on the formula, and this ingredient is capped at 1% int the EU.

Safety-wise, the fear mongering does not hold up to the evidence. The EU's Scientific Committee on Consumer Safety and FDA consider it safe as a preservative at up to 1%, including for children of all ages.

Adverse systemic effects only showed up in animal studies at exposures roughly 200x higher than what people get from cosmetics. And despite its very widespread use, this ingredient is a rare sensitizer and allergic reactions are uncommon.

Propylene Glycol is a synthetic, colorless, odorless liquid that has been a staple in cosmetics for decades. It is a skin conditioning agent, humectant, and solvent.

As a humectant, it draw water to the skin to reduce flaking and restore suppleness. It's also a solvent that helps dissolve other actives and keeps formulas stable across temperature changes.

The CIR Expert Panel has confirmed this ingredient to be nontoxic and clinical studies show no sensitization at cosmetic use concentrations.

True allergic reactions are quite rare: a 15-year retrospective study of 6,751 patients found only 0.31% had a positive reaction (and less than half were considered clinically relevant).

It seemed that when sensitization does occur, it's most commonly linked to topical medication (like corticosteroids) and not cosmetics. Allergic contact dermatitis also appears largely limited to individuals with underlying skin conditions.

Overall, propylene glycol is a well-studied ingredient that most people can tolerate without issue.

Salicylic Acid (also known as beta hydroxy acid or BHA) is a well-known ingredient for treating skin that struggles with acne and clogged pores. It exfoliates both the skin's surface and deep within the pores to help clear out buildup, control oil, and reduce inflammation.

Unlike AHAs (alpha hydroxy acids), salicylic acid is oil-soluble. This allows it to penetrate into pores which makes it especially effective for treating blackheads and preventing future breakouts.

Salicylic acid is also known for its soothing properties. It has a similar structure to aspirin and can calm inflamed or irritated skin, making it a good option for acne-prone skin that is also sensitive.

Concentrations of 0.5-2% are recognized by the U.S. FDA as an over-the-counter topical acne product.

It can cause irritation and/or dryness if one's skin already has a compromised moisture barrier, so it's best to focus on repairing that before introducing this ingredient into your routine.

While salicylic acid does not increase sun sensitivity, it’s still important to wear sunscreen daily to protect your skin.

If you are looking for the ingredient called BHA or Butylated Hydroxyanisole, click here.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

Similar Comparisons

Connected reading

Helpful context for this guide

Source-derived material selected through this article’s indexed topics.

P

About the author

Peptide Therapy Guide Editorial Team

Editorial team for Peptide Therapy Guide.

View all articles →