AMPLE:N Peptide Shot Ampoule 2x Versus MEDI-PEEL Peptide 9 Volume Bio Tox Ampoule Pro

AMPLE:N Peptide Shot Ampoule 2x Versus MEDI-PEEL Peptide 9 Volume Bio Tox Ampoule Pro

This anti-aging ampoule is formulated around Niacinamide and Adenosine to soften the look of wrinkles and refine skin texture.

What's inside

Key Ingredients

Benefits

Concerns

No concerns

Ingredients Side-by-side

Water

Glycerin

Butylene Glycol

Dipropylene Glycol

1,2-Hexanediol

Niacinamide

Polyglycerin-3

Adenosine

Beta-Glucan

Arginine

Dipotassium Glycyrrhizate

Sodium Hyaluronate

Mallotus Japonicus Bark Extract

Yeast Extract

Helichrysum Arenarium Extract

Copper Tripeptide-1

Acetyl Tetrapeptide-2

Carbomer

Dextran

Hydroxyethylcellulose

Caramel

Glyceryl Acrylate/Acrylic Acid Copolymer

Trifluoroacetyl Tripeptide-2

Xanthan Gum

Boron Nitride

Pvm/Ma Copolymer

Agar

Gellan Gum

Calcium Alginate

Caprylyl Glycol

Glucosylrutin

Palmitoyl Tripeptide-5

Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate

Magnesium Chloride

Disodium EDTA

Water, Glycerin, Butylene Glycol, Dipropylene Glycol, 1,2-Hexanediol, Niacinamide, Polyglycerin-3, Adenosine, Beta-Glucan, Arginine, Dipotassium Glycyrrhizate, Sodium Hyaluronate, Mallotus Japonicus Bark Extract, Yeast Extract, Helichrysum Arenarium Extract, Copper Tripeptide-1, Acetyl Tetrapeptide-2, Carbomer, Dextran, Hydroxyethylcellulose, Caramel, Glyceryl Acrylate/Acrylic Acid Copolymer, Trifluoroacetyl Tripeptide-2, Xanthan Gum, Boron Nitride, Pvm/Ma Copolymer, Agar, Gellan Gum, Calcium Alginate, Caprylyl Glycol, Glucosylrutin, Palmitoyl Tripeptide-5, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Magnesium Chloride, Disodium EDTA

Sodium Lactate

PEG-60 Hydrogenated Castor Oil

Ethylhexylglycerin

Actinidia Chinensis Fruit Extract

Eucalyptus Globulus Leaf Extract

Centella Asiatica Extract

Golden Extract

Polygonum Cuspidatum Root Extract

Propanediol

Glycyrrhiza Glabra Root Extract

Camellia Sinensis Leaf Extract

Sodium Hyaluronate Crosspolymer

Rosmarinus Officinalis Leaf Extract

Fructan

Chamomilla Recutita Extract

Hydrolyzed Glycosaminoglycans

Glycine

Polysorbate 80

Serine

Glutamic Acid

Hydrolyzed Elastin

Ectoin

Hydrogenated Polyisobutene

Benzyl Glycol

Aspartic Acid

Leucine

Oryza Sativa Extract

Astaxanthin

Hydrolyzed Hyaluronic Acid

Alanine

Lysine

Tyrosine

Phenylalanine

Valine

Threonine

Proline

Isoleucine

Histidine

Methionine

Cysteine

Palmitoyl Tetrapeptide-7

Hydrolyzed Sodium Hyaluronate

Hydrolyzed Collagen

Acetyl Octapeptide-3

Tripeptide-1

Palmitoyl Tripeptide-1

Palmitoyl Pentapeptide-4

Acetyl Hexapeptide-8

Sodium Benzoate

Sodium Acetylated Hyaluronate

Hexapeptide-9

Hydroxypropyltrimonium Hyaluronate

Hyaluronic Acid

Dimethylsilanol Hyaluronate

Nonapeptide-1

Pentylene Glycol

Hair Extract

Potassium Hyaluronate

Tocopherol

Alcohol

Parfum

Water, Glycerin, Butylene Glycol, Niacinamide, Sodium Lactate, 1,2-Hexanediol, Gellan Gum, PEG-60 Hydrogenated Castor Oil, Ethylhexylglycerin, Adenosine, Disodium EDTA, Actinidia Chinensis Fruit Extract, Eucalyptus Globulus Leaf Extract, Centella Asiatica Extract, Golden Extract, Polygonum Cuspidatum Root Extract, Propanediol, Glycyrrhiza Glabra Root Extract, Camellia Sinensis Leaf Extract, Sodium Hyaluronate Crosspolymer, Rosmarinus Officinalis Leaf Extract, Fructan, Chamomilla Recutita Extract, Sodium Hyaluronate, Hydrolyzed Glycosaminoglycans, Glycine, Caprylyl Glycol, Polysorbate 80, Serine, Glutamic Acid, Hydrolyzed Elastin, Ectoin, Hydrogenated Polyisobutene, Benzyl Glycol, Aspartic Acid, Leucine, Oryza Sativa Extract, Astaxanthin, Hydrolyzed Hyaluronic Acid, Alanine, Lysine, Arginine, Tyrosine, Phenylalanine, Valine, Threonine, Proline, Isoleucine, Histidine, Methionine, Cysteine, Palmitoyl Tetrapeptide-7, Hydrolyzed Sodium Hyaluronate, Hydrolyzed Collagen, Acetyl Octapeptide-3, Tripeptide-1, Palmitoyl Tripeptide-1, Palmitoyl Pentapeptide-4, Copper Tripeptide-1, Acetyl Hexapeptide-8, Sodium Benzoate, Sodium Acetylated Hyaluronate, Hexapeptide-9, Hydroxypropyltrimonium Hyaluronate, Hyaluronic Acid, Dimethylsilanol Hyaluronate, Nonapeptide-1, Pentylene Glycol, Hair Extract, Potassium Hyaluronate, Tocopherol, Alcohol, Parfum

Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Adenosine is a purine nucleoside that your body already makes in every cell. In skincare, it acts mainly as a skin conditioning and anti-aging agent.

The way it works is fairly well mapped out:

Your skin has cells called fibroblasts that build collagen (the stuff that keeps skin firm and smooth). Adenosine basically flips a switch on these cells that tells them to get to work making more collagen and other proteins. These cells slow down on their own as skin ages, so Adenosine helps give them a little nudge to keep going.

The clinical backing is pretty solid too.

A blind, randomized, placebo-controlled trial of 126 women aged 45-65 tested a 0.1% cream twice daily and found real improvements in crow's feet and frown lines using a precise 3D skin-mapping technique; these changes showed up by week 3 and held at 2 months.

A later study using Adenosine-loaded dissolving microneedle patches reported gains in wrinkle depth, dermal density, elasticity, and hydration.

On concentrations, South Korea's Ministry of Food and Drug Safety has set 0.04% as the approved functional anti-wrinkle level. You'll typically see this ingredient used somewhere in the 0.04-0.1% range since it works at low doses.

This ingredient has been found safe for cosmetics with the data showing no irritation or sensitization.

Overall, this is a great ingredient for any anti-aging routine and has no photosensitizing effect, so it suits both AM and PM use.

Arginine is a semi-essential amino acid. This just means our bodies can product a bit on its own, but sometimes needs a little boost from food sources.

It is a part of your skin's natural moisturizing factor (NMF), or the water-loving molecules in your outermost layer of skin (stratum corneum) that keeps everything hydrated and happy.

Here's an interesting thing about Arginine: your skin converts it into urea through the Krebs-Henseleit urea cycle. Urea is one of the most effective humectants your skin naturally produces.

A clinical study showed applying 2.5% arginine hydrochloride to atopic dermatitis skin showed significant urea levels in the stratum corneum and improved moisture in just four weeks.

Arginine is also a precursor to nitric oxide; nitric oxide improves microcirculation and supports wound healing and collagen synthesis.

One study found that an amino acid complex containing Arginine reduced skin irritation, improved hydration, and accelerated skin repair in clinical / in-vivo studies.

Arginine itself is an amino acid and not a fatty acid, oil, or ester. On its own, it's not a direct food source for Malassezia, or the yeast that causes fungal acne.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Caprylyl Glycol is a humectant, skin conditioner, emollient, and preservative booster derived from either caprylic acid or synthetically created.

Typical use levels vary from 0.3-1% as a preservative booster and go up to 2% to condition skin.

Because it is not a free-fatty acid, this ingredient is fungal acne safe (there's nothing for Malassezia to feed on).

Copper Tripeptide-1 (GHK-Cu) is a skin repairing ingredient known for its ability to boost collagen, improve firmness, and support skin regeneration.

It is a complex made up of a naturally occurring peptide (glycine-histidine-lysine) and copper, an essential trace element.

While studying wound healing, researchers noticed GHK-Cu stimulated hair follicle enlargement and growth by keeping hair in its active growth phase longer. This has made it a promising ingredient for hair regrowth treatments.

Some people have reported increased facial hair. While GHK-Cu can make your hair follicles bigger, it usually doesn’t turn soft, barely-visible facial hairs into thick, dark ones.

Anecdotal reports suggest that overusing copper peptides might lead to premature aging due to excess free copper or enzyme imbalances. This claim isn’t backed by large-scale studies.

Unfortunately, there are limited human studies for this ingredient. While early results are promising, many studies are either small, in-vitro, or not rigorously controlled.

For example, there is a 1998 study that explored the effects of copper tripeptide, vitamin C, tretinoin, and melatonin on skin repair and collagen synthesis.

After one month, increased procollagen production was seen in 7 out of 10 participants using copper tripeptide (more than those using vitamin C, melatonin, or tretinoin.

While the study was exploratory, it offers early evidence that copper tripeptide may support collagen production. Larger, well-designed trials are still needed to confirm its potential and understand individual responses.

Read more about other common types of peptides here:

Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.

This ingredient mainly works behind the scenes and helps with:

On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.

One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).

Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.

You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.

Gellan Gum is a high-molecular weight heteropolysaccharide gum. It is created by the process of pure-culture fermentation with the bacterium Pseudomonas elodea.

Gellan Gum is used to stabilize products. This helps improve the texture, consistency, and shelf life.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Niacinamide is a multitasking form of vitamin B3 that strengthens the skin barrier, reduces pores and dark spots, regulates oil, and improves signs of aging.

And the best part? It's gentle and well-tolerated by most skin types, including sensitive and reactive skin.

You might have heard of "niacin flush", or the reddening of skin that causes itchiness. Niacinamide has not been found to cause this.

In very rare cases, some individuals may not be able to tolerate niacinamide at all or experience an allergic reaction to it.

If you are experiencing flaking, irritation, and dryness with this ingredient, be sure to double check all your products as this ingredient can be found in all categories of skincare.

When incorporating niacinamide into your routine, look out for concentration amounts. Typically, 5% niacinamide provides benefits such as fading dark spots. However, if you have sensitive skin, it is better to begin with a smaller concentration.

When you apply niacinamide to your skin, your body converts it into nicotinamide adenine dinucleotide (NAD). NAD is an essential coenzyme that is already found in your cells as "fuel" and powers countless biological processes.

In your skin, NAD helps repair cell damage, produce new healthy cells, support collagen production, strengthen the skin barrier, and fight environmental stressors (like UV and pollution).

Our natural NAD levels start to decline with age, leading to slower skin repair, visible aging, and a weaker skin barrier. By providing your skin niacinamide, you're recharging your skin's NAD levels. This leads to stronger, healthier, and younger looking skin.

Another name for vitamin B3 is nicotinamide. This vitamin is water-soluble and our bodies don't store it. We obtain Vitamin B3 from either food or skincare. Meat, fish, wheat, yeast, and leafy greens contain vitamin B3.

The type of niacinamide used in skincare is synthetically created.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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