AMPLE:N Peptide Shot Ampoule 2x Versus AMPLE:N Centel Calming Shot Ampoule

AMPLE:N Peptide Shot Ampoule 2x Versus AMPLE:N Centel Calming Shot Ampoule

This anti-aging ampoule is formulated around Niacinamide and Adenosine to soften the look of wrinkles and refine skin texture.

This calming ampoule is formulated around Beta-Glucan and Centella Asiatica Extract to calm redness and strengthen the skin barrier.

What's inside

Key Ingredients

Benefits

Ingredients Side-by-side

Water

Glycerin

Butylene Glycol

Dipropylene Glycol

1,2-Hexanediol

Niacinamide

Polyglycerin-3

Adenosine

Beta-Glucan

Arginine

Dipotassium Glycyrrhizate

Sodium Hyaluronate

Mallotus Japonicus Bark Extract

Yeast Extract

Helichrysum Arenarium Extract

Copper Tripeptide-1

Acetyl Tetrapeptide-2

Carbomer

Dextran

Hydroxyethylcellulose

Caramel

Glyceryl Acrylate/Acrylic Acid Copolymer

Trifluoroacetyl Tripeptide-2

Xanthan Gum

Boron Nitride

Pvm/Ma Copolymer

Agar

Gellan Gum

Calcium Alginate

Caprylyl Glycol

Glucosylrutin

Palmitoyl Tripeptide-5

Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate

Magnesium Chloride

Disodium EDTA

Water, Glycerin, Butylene Glycol, Dipropylene Glycol, 1,2-Hexanediol, Niacinamide, Polyglycerin-3, Adenosine, Beta-Glucan, Arginine, Dipotassium Glycyrrhizate, Sodium Hyaluronate, Mallotus Japonicus Bark Extract, Yeast Extract, Helichrysum Arenarium Extract, Copper Tripeptide-1, Acetyl Tetrapeptide-2, Carbomer, Dextran, Hydroxyethylcellulose, Caramel, Glyceryl Acrylate/Acrylic Acid Copolymer, Trifluoroacetyl Tripeptide-2, Xanthan Gum, Boron Nitride, Pvm/Ma Copolymer, Agar, Gellan Gum, Calcium Alginate, Caprylyl Glycol, Glucosylrutin, Palmitoyl Tripeptide-5, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Magnesium Chloride, Disodium EDTA

Phaseolus Radiatus Seed Extract

Chamomilla Recutita Flower Extract

Centella Asiatica Callus Conditioned Media

Centella Asiatica Extract

Glycyrrhiza Glabra Root Extract

Allantoin

Madecassoside

Glycine Soja Sprout Extract

Hyaluronic Acid

Phyllostachys Nigra Juice

Rumex Crispus Root Extract

Betula Alba Juice

Viscum Album Extract

Octyldodeceth-16

Polyquaternium-51

Ammonium Acryloyldimethyltaurate/Vp Copolymer

Caprylic/Capric Triglyceride

Citric Acid

Water, Butylene Glycol, Glycerin, 1,2-Hexanediol, Beta-Glucan, Dipropylene Glycol, Phaseolus Radiatus Seed Extract, Chamomilla Recutita Flower Extract, Centella Asiatica Callus Conditioned Media, Centella Asiatica Extract, Glycyrrhiza Glabra Root Extract, Allantoin, Madecassoside, Glycine Soja Sprout Extract, Dipotassium Glycyrrhizate, Arginine, Sodium Hyaluronate, Hyaluronic Acid, Phyllostachys Nigra Juice, Rumex Crispus Root Extract, Betula Alba Juice, Viscum Album Extract, Octyldodeceth-16, Polyquaternium-51, Ammonium Acryloyldimethyltaurate/Vp Copolymer, Caprylic/Capric Triglyceride, Citric Acid, Disodium EDTA

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Alternatives

Ingredients Explained

These ingredients are found in both products.

Ingredients higher up in an ingredient list are typically present in a larger amount.

1,2-Hexanediol is a synthetic liquid and another multi-functional powerhouse.

It is a:

Humectant, drawing moisture into the skin

Emollient, helping to soften skin

Solvent, dispersing and stabilizing formulas

Preservative booster, enhancing the antimicrobial activity of other preservatives

Arginine is a semi-essential amino acid. This just means our bodies can product a bit on its own, but sometimes needs a little boost from food sources.

It is a part of your skin's natural moisturizing factor (NMF), or the water-loving molecules in your outermost layer of skin (stratum corneum) that keeps everything hydrated and happy.

Here's an interesting thing about Arginine: your skin converts it into urea through the Krebs-Henseleit urea cycle. Urea is one of the most effective humectants your skin naturally produces.

A clinical study showed applying 2.5% arginine hydrochloride to atopic dermatitis skin showed significant urea levels in the stratum corneum and improved moisture in just four weeks.

Arginine is also a precursor to nitric oxide; nitric oxide improves microcirculation and supports wound healing and collagen synthesis.

One study found that an amino acid complex containing Arginine reduced skin irritation, improved hydration, and accelerated skin repair in clinical / in-vivo studies.

Arginine itself is an amino acid and not a fatty acid, oil, or ester. On its own, it's not a direct food source for Malassezia, or the yeast that causes fungal acne.

Beta-Glucan is a soluble polysaccharide (a chain of glucose sugars) sourced from the cells walls of oats, baker's yeast, mushrooms, and seaweed.

It's a rare ingredient that pulls double-duty as a heavy-duty hydrator and skin-soothing repair agent.

On the surface, it acts as a humectant that holds water in place and reduces moisture loss for a plumper, smoother feel, while its anti-inflammatory and antioxidant properties make it a great pick for calming redness or sensitive skin

The more interesting story is underneath:

Despite its large molecular size, oat beta-glucan has been shown to penetrate the epidermis and reach the dermis by slipping between skin cells. Here, it interacts with fibroblasts and macrophages to nudge collagen synthesis and support wound repair.

A small 2005 split-face clinical study of 27 subjects found topical beta-glucan produced measurable reductions in wrinkle depth, height, and roughness after 8 weeks of use.

It is worth noting the trial was small and the penetration testing used frozen, irradiated skin so the anti-aging data is encouraging rather than definitive.

This ingredient gets along with pretty much everything and is typically used around 0.1-1%.

Fungal acne: This ingredient is not a food source for the Malassezia yeast because it is a glucose polysaccharide with no fatty acid or ester component.

Butylene Glycol (or BG) is used within cosmetic products for a few different reasons:

Overall, Butylene Glycol is a safe and well-rounded ingredient that works well with other ingredients.

Though this ingredient works well with most skin types, some people with sensitive skin may experience a reaction such as allergic rashes, closed comedones, or itchiness.

Dipotassium Glycyrrhizate comes from licorice root.

Extracts of licorice have demonstrated to have antibacterial, anti‐inflammatory, antiviral, antioxidant properties.

One component, glabridin, has extra potent antioxidant and soothing properties. It has also been found to block pigmentation from UVB rays in guinea pigs.

Licorice Root also contains a flavonoid. Flavonoids are a natural substance from in plants. Flavonoids also have antioxidant properties.

Another component, glycyrrhizin, has been found to have anti-inflammatory and antimicrobial benefits. This may make licorice root extract effective at treating acne. However, more research is needed to support this.

Liquiritin is one of the flavone compounds found in licorice. It has been found to help lighten skin by preventing tyrosinase from reacting with tyrosine. When the two react, protein is converted to melanin. Melanin is the substance in your body that gives your features pigmentation.

Licorice root is native to Southern Europe and Asia. It has been used in traditional Chinese medicine to help with respiratory issues.

Dipropylene Glycol is a synthetically created humectant, stabilizer, and solvent.

This ingredient helps:

Dipropylene glycol is technically an alcohol, but it belongs to the glycol family (often considered part of the ‘good’ alcohols). This means it is hydrating and gentle on skin unlike drying solvent alcohols like denatured alcohol.

As a masking agent, Dipropylene Glycol can be used to cover the smell of other ingredients. However, it does not have a scent.

Studies show Dipropylene Glycol is considered safe to use in skincare.

Disodium EDTA is a chelating agent. It grabs onto and deactivates metal ions that sneak into your products from water, packaging, or air.

This ingredient mainly works behind the scenes and helps with:

On top of that, this ingredient can counteract the effects of hard water by binding to the minerals in it.

One thing worth knowing is that Disodium EDTA has been shown to be a mild penetration enhancer. It can help other ingredients absorb into skin more effectively which can be a double-edged sword (great for actives, but can also make the active too strong if you have sensitive skin).

Clinical patch testing showed no significant skin irritation at typical use concentrations and minimal dermal absorption.

You'll most likely see this ingredient near the end of an ingredient list. It's typically found in concentrations less than 1%.

Glycerin (or glycerol) is a compound naturally found in your skin. It's a powerhouse humectant that pulls water into the stratum corneum.

Topically, glycerin does several things at once:

Your skin makes glycerin on its own (mostly from sebaceous oil breakdown) and shuttles it to your outermost layer of skin, or your epidermis, via aquaporin-3.

Aquaporin-3 is a transporter that is essential for normal skin hydration, elasticity, and repair. Interestingly, mice lacking in AQP3 have dry and less elastic skin that can be fully corrected with glycerin.

This ingredient is non-irritating, plays well with almost every ingredient, and works across all skin types. Typical use is anywhere between 3-10% but can go up to 79% in some leave-on products.

Just know very high concentrations (>40%) can feel tacky in low humidity.

Glycerin is the name for this ingredient in American English. British English uses Glycerol/Glycerine.

Sodium Hyaluronate is the salt form of hyaluronic acid. It is a long sugar chain that is naturally found in your skin, joints, and connective tissue that maintains hydration and elasticity.

In skincare, it works as a humectant. It pulls water from the environment and deeper layers of skin and binds it to the surface.

Interestingly, the size of the molecule affects its behavior:

Some clinical evidence links low molecular weight versions to improved wrinkle depth, elasticity, anti-inflammatory effects, and barrier repair.

Many serums use a blend of both weights so you can get surface hydration plus longer-lasting and deeper effects.

You'll typically see concentrations between 0.1-2% for this ingredient.

Water. It's the most common cosmetic ingredient of all. You'll usually see it at the top of ingredient lists, meaning that it makes up the largest part of the product.

So why is it so popular? Water most often acts as a solvent - this means that it helps dissolve other ingredients into the formulation.

You'll also recognize water as that liquid we all need to stay alive. If you see this, drink a glass of water. Remember to stay hydrated!

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