7031 - Gene ResultTFF1 trefoil factor 1 [ (human)]

Official Symbol TFF1provided by HGNC Official Full Name trefoil factor 1provided by HGNC Primary source HGNC:HGNC:11755 See related Ensembl:ENSG00000160182 MIM:113710; AllianceGenome:HGNC:11755 Gene type protein coding RefSeq status REVIEWED Organism Homo sapiens Lineage Eukaryota; Metazoa; Chordata; Craniata; Vertebrata; Euteleostomi; Mammalia; Eutheria; Euarchontoglires; Primates; Haplorrhini; Catarrhini; Hominidae; Homo Also known as pS2; BCEI; HPS2; HP1.A; pNR-2; D21S21 Summary Members of the trefoil family are characterized by having at least one copy of the trefoil motif, a 40-amino acid domain that contains three conserved disulfides. They are stable secretory proteins expressed in gastrointestinal mucosa. Their functions are not defined, but they may protect the mucosa from insults, stabilize the mucus layer, and affect healing of the epithelium. This gene, which is expressed in the gastric mucosa, has also been studied because of its expression in human tumors. This gene and two other related trefoil family member genes are found in a cluster on chromosome 21. [provided by RefSeq, Jul 2008] Expression Restricted expression toward stomach (RPKM 2677.9) See more Orthologs all Try the new Gene page
Try the new Transcripts and proteins table Location: 21q22.3 Exon count: 3

Annotation release	Status	Assembly	Chr	Location
RS_2025_08	current	GRCh38.p14 (GCF_000001405.40)	21	NC_000021.9 (42362282..42366535, complement)
RS_2025_08	current	T2T-CHM13v2.0 (GCF_009914755.1)	21	NC_060945.1 (40751729..40755982, complement)
RS_2024_09	previous assembly	GRCh37.p13 (GCF_000001405.25)	21	NC_000021.8 (43782391..43786644, complement)

Chromosome 21 - NC_000021.9

Genomic Sequence:

Related articles in PubMed

1. The trefoil peptide TFF1 inhibits the growth of the human gastric adenocarcinoma cell line AGS. Calnan DP, et al. J Pathol, 1999 Jul. PMID 10419601
2. Receiver-operating characteristic (ROC) curve analysis of cathepsin D and pS2 in breast disease; results from a prospective study. Eskelinen M, et al. Anticancer Res, 1999 Jul-Aug. PMID 10629636
3. pS2 (TFF1) levels in human breast cancer tumor samples: correlation with clinical and histological prognostic markers. Gillesby BE, et al. Breast Cancer Res Treat, 1999 Aug. PMID 10573116
4. The pS2 protein in primary colorectal carcinomas and in surrounding mucosa. Junco A, et al. Int J Biol Markers, 1999 Jul-Sep. PMID 10569143
5. pS2 negativity in postmenopausal women with ER+PgR+ infiltrating ductal breast carcinoma is associated with reduced hormone dependence and increased proliferation and aneuploidy of the tumors. Ruibal A, et al. Int J Biol Markers, 1999 Jul-Sep. PMID 10569142

See all (817) citations in PubMed

GeneRIFs: Gene References Into Functions

What's a GeneRIF?

1. The Transcription Factor RUNX1 Aggravates Hypoxia-Induced Human Retinal Microvascular Endothelial Cell Dysfunction by Negatively Regulating TFF1 Promoter.

   Title: The Transcription Factor RUNX1 Aggravates Hypoxia-Induced Human Retinal Microvascular Endothelial Cell Dysfunction by Negatively Regulating TFF1 Promoter.

2. Study on TFF1 and PALB2 gene variants associated with gastric carcinoma risk in the Chinese Han population.

   Title: Study on TFF1 and PALB2 gene variants associated with gastric carcinoma risk in the Chinese Han population.

3. IFNgamma-dependent silencing of TFF1 during Helicobacter pylori infection.

   Title: IFNγ-dependent silencing of TFF1 during Helicobacter pylori infection.

4. TFF1 gene single nucleotide polymorphism (rs3761376) and colorectal cancer risk.

   Title: TFF1 gene single nucleotide polymorphism (rs3761376) and colorectal cancer risk.

5. Association of functional genetic variants in TFF1 and nephrolithiasis risk in a Chinese population.

   Title: Association of functional genetic variants in TFF1 and nephrolithiasis risk in a Chinese population.

6. Trefoil factor 1 inhibits the development of esophageal adenocarcinoma from Barrett's epithelium.

   Title: Trefoil factor 1 inhibits the development of esophageal adenocarcinoma from Barrett's epithelium.

7. The trefoil factor family 1 (TFF-1) and 3 (TFF-3) are upregulated in the saliva, gingival crevicular fluid and serum of periodontitis patients.

   Title: The trefoil factor family 1 (TFF-1) and 3 (TFF-3) are upregulated in the saliva, gingival crevicular fluid and serum of periodontitis patients.

8. Association between Promotor hypomethylation of TFF1 and Crohn's Disease.

   Title: Association between Promotor hypomethylation of TFF1 and Crohn's Disease.

9. Circulating trefoil factors in relation to lung cancer, age and lung function: a cross-sectional study in patients referred for suspected lung cancer.

   Title: Circulating trefoil factors in relation to lung cancer, age and lung function: a cross-sectional study in patients referred for suspected lung cancer.

10. Circ-TFF1 Facilitates Breast Cancer Development via Regulation of miR-338-3p/FGFR1 Axis.

    Title: Circ-TFF1 Facilitates Breast Cancer Development via Regulation of miR-338-3p/FGFR1 Axis.

Find tests for this gene in the NIH Genetic Testing Registry (GTR)

Review eQTL and phenotype association data in this region using PheGenI

EBI GWAS Catalog

Description
Genome-wide association study identifies five loci associated with susceptibility to pancreatic cancer in Chinese populations.

Products	Interactant	Other Gene	Complex	Source	Pubs	Description

Markers

• GDB:185151 (e-PCR)
  • UniSTS:155409

• SHGC-35308 (e-PCR)
  • UniSTS:26661

• GDB:192309 (e-PCR)
  • UniSTS:155707

• PMC350567P1 (e-PCR)
  • UniSTS:273241

Preferred Names trefoil factor 1 Names breast cancer estrogen-inducible protein breast cancer estrogen-inducible sequence gastrointestinal trefoil protein pS2 polypeptide P1.A protein pS2

NEW Try the new Transcript table

RefSeqs maintained independently of Annotated Genomes

RefSeqs of Annotated Genomes: GCF_000001405.40-RS_2025_08

The following sections contain reference sequences that belong to a specific genome build. Explain

Reference GRCh38.p14 Primary Assembly

Genomic

1. NC_000021.9 Reference GRCh38.p14 Primary Assembly

   Range 42362282..42366535 complement Download GenBank, FASTA, Sequence Viewer (Graphics)

Alternate T2T-CHM13v2.0

Genomic

1. NC_060945.1 Alternate T2T-CHM13v2.0

   Range 40751729..40755982 complement Download GenBank, FASTA, Sequence Viewer (Graphics)