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Trifluoroacetic acid (TFA) is ubiquitous in peptide synthesis, serving as a cleavage reagent during solid-phase synthesis and as an ion-pairing agent in HPLC purification. Consequently, synthetic peptides are …
Read guide →The continual fission and fusion the Mitochondria undergoes to change its shape and function are a key trait of the organelle, one that is regulated by the enzyme OMA1. However, there is little known regarding…
Read guide →A highly conserved cryptic epitope in the receptor-binding domains of SARS-CoV-2, LT5578, was cited by Nature (Potently neutralizing and protective human antibodies against SARS-CoV-2, volume 584, pages443–449…
Read guide →There are many methods to modify cysteine, which include alkylation, conjugate addition, oxidation, and reduction. Recently, it was found that it is possible to arylate cysteine in the context of bioconjugatio…
Read guide →Most of the potential therapeutic peptides have low solubility, chemical instability or low stability against protease. So it is essential to modify and optimize the peptides to improve the peptide bioavailabi…
Read guide →Jia Shen. et al. EGFR modulates microRNA maturation in response to hypoxia through phosphorylation of AGO2. Nature 497, 383–387 (16 May 2013), doi:10.1038/nature12080 LifeTein helped designed and synthesized a…
Read guide →Polypeptides are used as new drug candidates to target specific disease symptoms. However, peptide drugs are rapidly degraded by proteolytic enzymes and neutralized by antibodies. Pegylation of polypeptide dru…
Read guide →Phosphorylated peptides are a result of a widespread post-translational modification that occurs as a result of esterification of amino acid side chains in peptides. This process involves the addition of a str…
Read guide →The chronic autoinflammatory bowel disease ulcerative colitis affects millions around the world. The condition involves autoreactive T cells and macrophages in the colonic mucosa attacking healthy colon cells,…
Read guide →Many sensory declines accompany aging, one of which is sight. That being said, there is a need for much more research on the visual changes associated with such aging. Specifically, the changes in rod bipolar …
Read guide →The concept of self-assembling peptides is a promising front where construction of devices can be achieved through a single molecule. While the outcome is enticing, the means to reach a consistent outcome are …
Read guide →Lipid nanoparticles (LNPs) have emerged as a promising platform for drug delivery and gene therapy. When combined with peptides, these nanoparticles offer enhanced stability, targeted delivery, and reduced tox…
Read guide →LifeTein’s Innovative Peptide Antagonist: A New Ally in the Fight Against Breast Cancer Metastasis Breast cancer stands as the most commonly diagnosed cancer in women worldwide and is a leading cause of cancer…
Read guide →The PADRE peptide (Pan-DR epitope) is a synthetic peptide designed to bind to a wide range of human MHC class II molecules. This characteristic makes it a universal helper T-cell epitope, which is crucial in e…
Read guide →Cancer is a patient-specific disease, where no two tumors are alike. Neoepitopes are very frequent in all cancers. Amino acid substitutions can yield neoantigens that are detected by the immune system. So neoa…
Read guide →Phosphorylation plays a vital role in regulating cellular processes. Each phosphorylation pattern leads to different interactions and could result in distinct biological outcomes. Single phosphorylated peptide…
Read guide →Cell interaction analysis is a cornerstone of biological research, providing critical insights into the intricate world of molecular communication within living organisms. While traditional microscopy offers a…
Read guide →LifeTein’s cysteine-containing peptides helped researchers better understand the effect peptide physicochemical properties have on the pharmacokinetic profiles of the nanoparticles they are attached to. Better…
Read guide →Researchers at the University of California, San Francisco (UCSF), in collaboration with LifeTein, have made a groundbreaking discovery in the field of pain management. LifeTein’s expertise in peptide synthesi…
Read guide →The use of mobile microrobots offers a promising solution for targeted medical theranostic applications at normally inaccessible regions of the human body. Namely, the circulatory system is an ideal region for…
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