JJLabs Skincare Solution Peptide Complex Anti Aging Serum

JJLabs Skincare Solution Peptide Complex Anti Aging Serum JJLabs Skincare Solution Peptide Complex Anti Aging Serum ingredients explained: Hyaluronic Acid, EGF (Rh-Oligopeptide-1), Copper Peptides (Ghk-Cu), Argireline, Water, Acetyl Hexapeptide-8, Sodium Benzoate, Gamma-Polyglutamic Acid (G-Pga), Gluconolactone, Ginseng, Potassium Sorbate, Citric Acid, Distilled Water Show all ingredients by function Hyaluronic Acid skin-identical ingredient, moisturizer/​humectant goodie EGF (Rh-Oligopeptide-1) cell-communicating ingredient Copper Peptides (Ghk-Cu) cell-communicating ingredient, soothing, antioxidant Water solvent Acetyl Hexapeptide-8 cell-communicating ingredient, moisturizer/​humectant Sodium Benzoate preservative Gamma-Polyglutamic Acid (G-Pga) moisturizer/​humectant Gluconolactone exfoliant, chelating superstar Ginseng antioxidant, emollient Potassium Sorbate Citric Acid buffering Distilled Water It’s naturally in our skin and behaves there like a sponge It can bind up to 1000 times its own weight in water It is a big molecule from repeated subunits (polymer) so different molecular weight versions exist (unfortunately there is no way to determine MW from INCI list only) High-molecular-weight-HA (>500 kDa) is an excellent surface hydrator, skin protectant and can act as an osmotic pump helping water-soluble actives to penetrate deeper into the skin Low-molecular-weight-HA (< 500 kDa) can hydrate the skin somewhat deeper though it is still a big molecule and works mainly in the epidermis (outer layer of the skin) Low-molecular-weight-HA might also help the skin to repair itself by increasing its self-defense (~ 200kDa used in the study) Ultra-low-molecular-weight-HA (<50kDa) is a controversial ingredient and might work as a pro-inflammatory signal molecule Sh-Oligopeptide-1 is the famous molecule, which is also called Epidermal Growth Factor or EGF. Chemically speaking, Growth Factors are largish peptides or smallish proteins, or to put it in another way, medium-length amino acid sequences (EGF consists of 53 amino acids). Biologically speaking, Growth Factors are cellular signal molecules that can stimulate cell growth, proliferation, healing and/or differentiation. There are lots of Growth Factors and EGF is just one of them. The topic of "Growth Factors and skincare" is a big, confusing and controversial one and we will try our best to summarize the story for you, including the pros and the cons. Expand to read more EGF is a special snowflake when it comes to skincare as it was the first Growth Factor that made its way into cosmetic products and it is also the most common one. The American biochemist, Stanley Cohen discovered EGF and was awarded a Noble prize in 1986 for it. As the Noble prize may signify, the molecule is significant and powerful and directly stimulates the proliferation of epidermal cells. When it comes to Sh-Oligopeptide-1 in a cosmetic product, it has pretty well-established wound healing and skin renewal properties. It might even do more than that. According to a 2012 study on a serum containing barley bioengineered epidermal growth factor, "clinical evaluations showed statistically significant improvement in the appearance of fine lines and rhytids, skin texture, pore size, and various dyschromatic conditions apparent within the first month of use, and continuing improvement trends for the duration of the study" (which was 3 months). This all sounds amazing, "give me some EGF Serum", we can hear you say! But as we wrote in the intro, the topic is complex and controversial so here are some of the questions that keep coming up around slathering EGF all over our face. The first and biggest concern is that if EGF is so good at stimulating cell proliferation, how does it relate to cancer? Is the definition of cancer not "cells proliferating out of control"? Most experts agree on this answer: EGF is mitogenic (= stimulate what‑it‑does skin-identical ingredient | moisturizer/humectant cell-communicating ingredient | soothing | antioxidant cell-communicating ingredient | moisturizer/humectant moisturizer/humectant exfoliant | chelating antioxidant | emollient