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Wolverine Stack Research Protocols: Comparison
Sequential Titration (8-week) 300mcg daily × 10 days, then 600mcg AM 250mcg added week 2, split AM/PM 5mL IM on days 1, 4, 7 of weeks 4–8 BDNF at weeks 0/3/6, digit span weekly, cortisol reactivity at baseline/week 4/week 8 Gold standard for isolating individu
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- Sequential Titration (8-week)
- 300mcg daily × 10 days, then 600mcg AM
- 250mcg added week 2, split AM/PM
- 5mL IM on days 1, 4, 7 of weeks 4–8
- BDNF at weeks 0/3/6, digit span weekly, cortisol reactivity at baseline/week 4/week 8
- Gold standard for isolating individual compound effects. Longest timeline, highest compliance burden
- Simultaneous Loading (4-week)
- 600mcg AM from day 1
- 500mcg AM from day 1
- 10mL IV twice weekly entire protocol
- Subjective mood scales, n-back testing weekly
- Higher dropout rate (35%) due to overstimulation; difficult to attribute effects to specific compounds
- Semax-Focused (6-week)
- 600mcg AM daily, full protocol
- None
- Working memory, processing speed, BDNF at weeks 0/3/6
- Cleanest data on Semax alone. No synergy effects, serves as single-agent control
- Selank-Focused Anxiolytic (4-week)
- 750mcg split AM/noon
- Cortisol sampling, HRV monitoring, subjective anxiety scales
- Isolates stress modulation without confounding neuroplasticity variables
- Maintenance Micro-Dose (12-week)
- 300mcg 5 days/week
- 250mcg 5 days/week
- 5mL IM once every 10 days
- Quarterly BDNF, monthly cognitive testing
- Mimics long-term use patterns. Lower peak effects, potentially sustainable