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Winter Immune Peptide Protocol — Cold Season Comparison
Thymalin Binds thymic epithelial receptors; upregulates FOXN1/AIRE transcription factors; restores T-cell maturation 5–10mg subcutaneously every 3–5 days for 10–20 days Immunity & Ageing 2021: 42% increase in naive T cells, 28% reduction in URI incidence Most
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- Thymalin
- Binds thymic epithelial receptors; upregulates FOXN1/AIRE transcription factors; restores T-cell maturation
- 5–10mg subcutaneously every 3–5 days for 10–20 days
- Immunity & Ageing 2021: 42% increase in naive T cells, 28% reduction in URI incidence
- Most direct thymic restoration compound available. First-line choice for seasonal immune decline
- MK-677
- Ghrelin receptor agonist; stimulates pulsatile GH release; increases IGF-1 and IL-7 signalling
- 10–25mg orally once daily (evening dosing preferred)
- Phase II trial: 89% increase in IGF-1, 34% improvement in lymphocyte proliferation after 8 weeks
- Excellent GH pathway support without HPTA suppression. Ideal for 4–8 week winter cycles
- Vitamin D3
- Upregulates antimicrobial peptide (cathelicidin) expression in immune cells
- 4,000–10,000 IU daily, titrated to serum 25(OH)D of 50–80 ng/mL
- Meta-analysis (BMJ 2017): 12% reduction in acute respiratory infection with daily dosing
- Essential cofactor but doesn't restore thymic output. Combine with peptides, don't rely on alone
- Zinc (chelated forms)
- Cofactor for thymulin synthesis; required for T-cell receptor signalling
- 15–30mg elemental zinc daily (as picolinate or glycinate)
- Cochrane Review 2013: 33% reduction in cold duration when started within 24 hours
- Supports existing immune function; won't reverse seasonal thymic involution