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What's the Half-Life of Tesofensine?: Comparison to Other Weight Loss Compounds

This table shows how tesofensine's extended half-life compares to commonly used anti-obesity medications. And why that pharmacokinetic difference shapes dosing, side effect duration, and discontinuation protocols. Tesofensine ~8 days (190 hours) Once weekly 5–

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This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.

  • This table shows how tesofensine's extended half-life compares to commonly used anti-obesity medications. And why that pharmacokinetic difference shapes dosing, side effect duration, and discontinuation protocols.
  • Tesofensine
  • ~8 days (190 hours)
  • Once weekly
  • 5–6 weeks
  • 40 days
  • Extended half-life enables weekly dosing but requires 6-week washout before surgery or other serotonergic drugs; side effects persist weeks after stopping
  • Phentermine
  • 19–24 hours
  • Daily
  • 4–5 days
  • 5 days
  • Short half-life requires daily dosing; abrupt discontinuation causes immediate rebound hunger but full clearance within one week
  • Semaglutide (GLP-1)
  • ~7 days (165 hours)
  • 4–5 weeks
  • 35 days
  • Similar half-life to tesofensine but different mechanism (GLP-1 agonism vs monoamine reuptake inhibition); weekly dosing with extended washout
  • Liraglutide (GLP-1)
  • 13 hours
  • 3 days
  • 65 hours
  • Shorter GLP-1 agonist requiring daily injection; side effects resolve within 48–72 hours of stopping
  • Bupropion
  • 21 hours
  • Daily or twice daily
  • Norepinephrine-dopamine reuptake inhibitor (overlapping mechanism with tesofensine) but shorter half-life; requires daily dosing, clears within one week