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What's the dose range for cognitive enhancement versus being too much?
The cognitive 'sweet spot' is 0.5-2 mg/kg body weight (roughly 35-140 mg for a 70 kg person). Doses above 2 mg/kg often shift from antioxidant to pro-oxidant effects, becoming counterproductive for cognition. Standard dosing is 50-100 mg in the morning; start
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- The cognitive 'sweet spot' is 0.5-2 mg/kg body weight (roughly 35-140 mg for a 70 kg person). Doses above 2 mg/kg often shift from antioxidant to pro-oxidant effects, becoming counterproductive for cognition. Standard dosing is 50-100 mg in the morning; start low and titrate up. More is not better—methylene blue follows a hormetic dose-response curve where excessive doses impair function.