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Top Oxytocin Studies: Key Mechanism and Dose Comparison
Kosfeld et al. (2005) 17% increase in trust-based financial decisions 24 IU intranasal, single dose Social-specific risk assessment via prefrontal cortex modulation Trust behavior is dose- and context-dependent Ditzen et al. (2009) 31% lower post-conflict cort
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- Kosfeld et al. (2005)
- 17% increase in trust-based financial decisions
- 24 IU intranasal, single dose
- Social-specific risk assessment via prefrontal cortex modulation
- Trust behavior is dose- and context-dependent
- Ditzen et al. (2009)
- 31% lower post-conflict cortisol in secure-attachment couples
- 24 IU intranasal before conflict discussion
- HPA axis modulation contingent on attachment style
- Effect amplifies baseline interpersonal patterns
- Hurlemann et al. (2010)
- 43% reduced amygdala activation to fearful faces
- 24 IU intranasal, fMRI protocol
- Amygdala threat-detection circuit inhibition
- Specific to social threat, not general anxiety
- Insel prairie vole studies
- Pair-bonding depends on nucleus accumbens receptor density
- Agonist administration or receptor blockade
- Oxytocin receptor density in reward circuitry
- Species-level social behavior governed by receptor distribution
- Andari et al. (2010) ASD trial
- Improved trustworthiness judgment and eye gaze in ASD
- 24 IU intranasal before social task
- Enhanced social salience via amygdala-prefrontal connectivity
- Largest effect in low-baseline social cognition groups