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Thymalin Work for Thymus Peptide Research: Protocol Comparison
Administration Schedule 5mg/kg SC daily × 10 days 10mg/kg SC daily × 14 days 10mg/kg SC single dose Extended dosing required for measurable thymic weight increase. Single-dose protocols consistently fail to reach significance Measurement Timepoint 72 hours pos
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- Administration Schedule
- 5mg/kg SC daily × 10 days
- 10mg/kg SC daily × 14 days
- 10mg/kg SC single dose
- Extended dosing required for measurable thymic weight increase. Single-dose protocols consistently fail to reach significance
- Measurement Timepoint
- 72 hours post-final dose
- 96 hours post-final dose
- 24 hours post-dose
- Peak naïve T-cell output occurs 72–96 hours after final dose. Earlier timepoints miss the effect window
- Expected Thymic Weight Increase
- 20–28% vs aged controls
- 30–40% vs aged controls
- 0–5% (non-significant)
- Sustained IL-7 elevation over 10–14 days drives TEC proliferation. Transient exposure insufficient
- CD4+/CD8+ Ratio Change
- +15–22% vs baseline
- +25–35% vs baseline
- No significant change
- Dose-dependent naïve T-cell output restoration correlates with improved CD4+/CD8+ ratio in peripheral blood
- Replication Success Rate
- ~65% (published studies)
- ~78% (published studies)
- <10% (null results)
- Longer protocols with higher cumulative dose show better cross-lab reproducibility when peptide purity ≥98%
- Peptide Purity Requirement
- ≥95% HPLC
- ≥98% HPLC
- Any (often unreported)
- Single-dose studies tolerate lower purity because immune confounders don't accumulate; extended protocols amplify contamination effects