Understand the source comparison
TB-4 Half-Life Comparison: Peptides and Analogues
TB-4 (Thymosin Beta-4) 2–3 hours 2–3× daily Renal filtration + enzymatic degradation Short half-life requires frequent dosing; best suited for protocols where twice-daily administration is feasible BPC-157 4–6 hours (estimated) 1–2× daily Enzymatic degradation
No winner is assigned.
This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- TB-4 (Thymosin Beta-4)
- 2–3 hours
- 2–3× daily
- Renal filtration + enzymatic degradation
- Short half-life requires frequent dosing; best suited for protocols where twice-daily administration is feasible
- BPC-157
- 4–6 hours (estimated)
- 1–2× daily
- Enzymatic degradation; minimal renal clearance
- Longer half-life allows once-daily dosing in most research applications
- GHK-Cu (Copper Peptide)
- 1.5–2 hours
- Rapid plasma copper dissociation + peptide degradation
- Similar clearance kinetics to TB-4; requires frequent dosing or topical application to maintain levels
- Epithalon (Epitalon)
- 2–4 hours
- Renal filtration; small molecular weight (4 amino acids)
- Brief half-life but often dosed once daily due to cellular effects outlasting plasma presence
- Selank
- 15–25 minutes
- 2–3× daily (or intranasal for CNS)
- Extremely rapid enzymatic cleavage in serum
- Shortest half-life of common research peptides; intranasal bypasses systemic clearance for CNS targeting