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TB-4 Anti-Fibrotic Protocol: Dosing Comparison
Acute Prevention (injury <2 weeks) 7–10mg 3x weekly 4–8 weeks Block TGF-β1 during peak inflammatory phase, prevent collagen deposition Highest efficacy window. Start immediately post-injury for maximum fibrosis reduction Chronic Remodeling (injury >3 months) 3
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- Acute Prevention (injury <2 weeks)
- 7–10mg
- 3x weekly
- 4–8 weeks
- Block TGF-β1 during peak inflammatory phase, prevent collagen deposition
- Highest efficacy window. Start immediately post-injury for maximum fibrosis reduction
- Chronic Remodeling (injury >3 months)
- 3–5mg
- 2x weekly
- 12–16 weeks
- Upregulate MMP-2 to slowly degrade cross-linked collagen
- Modest improvement over extended timeline. Irreversible cross-linking limits reversal
- Maintenance After Acute Protocol
- 2–3mg
- 1x weekly
- Sustain anti-fibrotic signaling during final remodeling phase
- Prevents rebound fibrosis as endogenous TGF-β1 normalizes