Understand the source comparison
SS-LUP-332 Not Working Reasons Fix: Comparison Analysis
Storage temperature excursion No observable effect despite proper dosing; peptide appears unchanged visually Discard current vial; source replacement with verified cold chain; do not attempt salvage Store lyophilised powder at −20°C; refrigerate reconstituted
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- Storage temperature excursion
- No observable effect despite proper dosing; peptide appears unchanged visually
- Discard current vial; source replacement with verified cold chain; do not attempt salvage
- Store lyophilised powder at −20°C; refrigerate reconstituted solution at 2–8°C; use insulated transport with gel packs rated for full transit time
- Storage failures account for 40–50% of reported non-response cases. The peptide cannot be 'rescued' once denatured
- Incorrect reconstitution ratio
- Unexpected dose response (too strong or too weak); calculation errors when switching vial sizes
- Recalculate concentration: [mg peptide] ÷ [mL water] = mg/mL; adjust syringe draw volume accordingly
- Use consistent vial sizes; label each vial with concentration and reconstitution date; verify math before first draw
- Concentration errors cascade across entire dosing schedule. A single miscalculation affects every subsequent administration
- Contaminated or expired bacteriostatic water
- Cloudy solution after reconstitution; visible particulates; solution develops odour
- Discard vial immediately; do not inject; source new bacteriostatic water with verifiable expiration date
- Use only bacteriostatic water (0.9% benzyl alcohol); verify expiration date before use; store sealed vials at room temperature away from light
- Water contamination introduces endotoxins that trigger immune response and degrade peptide within 24–48 hours
- Injection timing (fed vs fasted state)
- Inconsistent response; works some administrations but not others
- Standardise administration to fasted state (8–12 hours post-meal); maintain consistent timing across protocol
- Administer at same time daily; track meal timing and metabolic state; avoid post-meal injections for metabolic peptides
- Fed-state administration can reduce bioavailability by 30–50% for ERR agonists due to competing insulin signalling