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SS-LUP-332 Exercise Mimetic: Compound Comparison
SS-LUP-332 ERRα/γ agonist → PGC-1α transcription → mitochondrial biogenesis Day 5–7: mild stamina improvement Day 14–21: measurable oxidative capacity gains Daily (half-life 6–8 hours) Best-in-class exercise mimetic with strongest preclinical endurance data. T
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- SS-LUP-332
- ERRα/γ agonist → PGC-1α transcription → mitochondrial biogenesis
- Day 5–7: mild stamina improvement
- Day 14–21: measurable oxidative capacity gains
- Daily (half-life 6–8 hours)
- Best-in-class exercise mimetic with strongest preclinical endurance data. Timeline matches natural training adaptation
- AICAR
- Direct AMPK activator → shifts fuel utilisation to fat oxidation
- Day 3–5: slight energy steadiness during fasted cardio
- Day 10–14: improved fat oxidation markers
- Daily to twice daily (short half-life)
- Older-generation mimetic with weaker mitochondrial biogenesis signal. Faster subjective onset but lower peak adaptation
- GW501516 (Cardarine)
- PPARδ agonist → fatty acid oxidation upregulation
- Day 2–4: noticeable endurance boost during cardio
- Day 7–10: fat oxidation enzyme expression increases
- Daily (half-life ~24 hours)
- Subjectively faster onset but lacks direct mitochondrial biogenesis driver. More acute metabolic shift than chronic adaptation
- Resveratrol (high-dose)
- Weak AMPK activator + SIRT1 activation
- Minimal subjective changes
- Day 21–30+: modest mitochondrial improvements in some studies
- Daily (bioavailability issues)
- Requires extremely high doses (500mg+) for marginal effects. Timeline too slow and effect size too small for practical mimetic use