Understand the source comparison
SS-LUP-332 ERR Agonist Results Timeline Expect: Model Comparison
C2C12 Myotubes (in vitro) 48–72 hours (PGC-1a mRNA) 7–10 days (OCR +40–60%) 10–14 days 5–7 days (mRNA); 10–14 days (protein) Fastest timeline. Useful for mechanism studies but overstates in vivo kinetics Rodent Models (diet-induced obesity) 7–10 days (mitochon
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- C2C12 Myotubes (in vitro)
- 48–72 hours (PGC-1a mRNA)
- 7–10 days (OCR +40–60%)
- 10–14 days
- 5–7 days (mRNA); 10–14 days (protein)
- Fastest timeline. Useful for mechanism studies but overstates in vivo kinetics
- Rodent Models (diet-induced obesity)
- 7–10 days (mitochondrial protein)
- 6–8 weeks (RER shift, fat oxidation)
- 10–12 weeks
- 6–8 weeks to baseline
- Standard preclinical model. Timeline generalizes well to primates
- Non-Human Primate Studies
- 10–14 days (gene expression)
- 8–12 weeks (metabolic rate, substrate preference)
- 12–16 weeks
- 8–10 weeks to baseline
- Most translatable to human timelines. Slower onset, more durable effects
- Human Skeletal Muscle Biopsy Data
- 7–10 days (mitochondrial DNA, OXPHOS)
- 8–10 weeks (VO2max, fat oxidation during exercise)
- 12 weeks (estimated)
- Unknown. No withdrawal studies published
- Limited data. Extrapolated from exercise training studies with ERR upregulation