Understand the source comparison
SS-LUP-332 Dosage ERR Agonist: Protocol Comparison
Metabolic (glucose oxidation, FAO) 10–30mg Once or twice daily Morning fasted or pre-feeding window PGC-1α upregulation, OXPHOS gene expression, mitochondrial density Lower doses work when timed correctly. 20mg fasted outperforms 40mg fed Endurance (time to ex
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This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- Metabolic (glucose oxidation, FAO)
- 10–30mg
- Once or twice daily
- Morning fasted or pre-feeding window
- PGC-1α upregulation, OXPHOS gene expression, mitochondrial density
- Lower doses work when timed correctly. 20mg fasted outperforms 40mg fed
- Endurance (time to exhaustion, VO2 max)
- 40–50mg
- Twice daily or 90min pre-exercise
- Fasted, pre-activity window
- Exercise capacity, lactate threshold, fatigue resistance
- Higher dose needed to compete with exercise-induced endogenous ERR activation
- Mitochondrial biogenesis (long-term)
- 15–25mg
- Twice daily
- Split dosing fasted AM/PM
- Mitochondrial DNA copy number, cristae density, respiration capacity
- Split dosing maintains stable receptor occupancy across circadian cycles
- Off-target minimization (research safety)
- 10–20mg
- Once daily
- Morning fasted
- Same endpoints as metabolic, lower side effect incidence
- Start low. Many endpoints respond fully at 15–20mg without needing escalation