Understand the source comparison
Speed Up Metabolism with Peptides: Compound Comparison
Before selecting a peptide for metabolic research, compare mechanisms, half-lives, and dosing complexity to match your experimental design. AMPK Activators (AICAR) Direct AMPK phosphorylation → fatty acid oxidation, glucose uptake 30–60 minutes Daily or twice-
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This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- Before selecting a peptide for metabolic research, compare mechanisms, half-lives, and dosing complexity to match your experimental design.
- AMPK Activators (AICAR)
- Direct AMPK phosphorylation → fatty acid oxidation, glucose uptake
- 30–60 minutes
- Daily or twice-daily
- 15–25% increase in substrate oxidation within 2–6 hours
- Best for acute metabolic shifts; requires consistent dosing due to short half-life
- GH Secretagogues (MK 677, Ipamorelin)
- Ghrelin receptor agonism → pulsatile GH release → lipolysis, protein synthesis
- 2–24 hours (compound-dependent)
- Daily to every other day
- 8–15% increase in resting energy expenditure
- Effective for sustained metabolic elevation; requires caloric deficit for fat loss
- Long-Acting GH Analogs (CJC-1295)
- Continuous GH receptor stimulation
- 6–8 days
- Weekly
- 10–18% increase in lean mass maintenance cost
- Lowest injection frequency; best for long-term studies
- Mitochondrial Biogenesis Inducers
- PGC-1α upregulation → increased mitochondrial density
- Varies by compound
- Protocol-dependent
- 20–30% increase in oxidative capacity after 14+ days
- Slowest onset but most durable metabolic adaptation