Understand the source comparison
SLU-PP-332 Endurance Protocol: Dosing Comparison
Acute Performance 20mg/kg 2 hours pre-activity Single dose Immediate oxidative capacity increase (70% in Scripps study) Best for proof-of-concept studies; not sustainable long-term Sustained Training Enhancement 10–15mg/kg Daily, 4–6 PM (human circadian peak)
No winner is assigned.
This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- Acute Performance
- 20mg/kg
- 2 hours pre-activity
- Single dose
- Immediate oxidative capacity increase (70% in Scripps study)
- Best for proof-of-concept studies; not sustainable long-term
- Sustained Training Enhancement
- 10–15mg/kg
- Daily, 4–6 PM (human circadian peak)
- 4 weeks on / 2 weeks off
- Progressive mitochondrial adaptation without receptor burnout
- Gold standard for endurance research protocols
- Low-Dose Metabolic Support
- 5–8mg/kg
- Daily, consistent timing
- Continuous (monitor closely)
- Mild mitochondrial gene expression without major circadian disruption
- Experimental. Limited data on long-term low-dose effects
- High-Dose Rapid Adaptation
- 20–25mg/kg
- Daily, strict circadian timing required
- 2 weeks max
- Maximal REV-ERB activation; significant circadian side effects likely
- Use only in controlled settings with circadian monitoring