Understand the source comparison
Signs LL-37 Gone Bad Degraded: Storage and Stability Comparison
The table below compares storage conditions, expected shelf life, and degradation indicators for LL-37 in different states. Use this to assess whether your peptide is still viable or has been compromised. Lyophilised powder at −20°C (unopened) 12–24 months Min
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This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- The table below compares storage conditions, expected shelf life, and degradation indicators for LL-37 in different states. Use this to assess whether your peptide is still viable or has been compromised.
- Lyophilised powder at −20°C (unopened)
- 12–24 months
- Minimal. Moisture infiltration only if seal fails
- Powder remains white, fluffy, intact cake
- Full potency retained
- Gold standard. Store here until ready to reconstitute
- Lyophilised powder at 2–8°C (refrigerator)
- 3–6 months
- Slow hydrolysis if moisture present; reduced long-term stability
- Powder may yellow slightly over months
- 5–10% potency loss over 6 months
- Acceptable short-term but not ideal for long-term storage
- Reconstituted in bacteriostatic water at 2–8°C
- 28 days
- Gradual hydrolysis of peptide bonds; bacterial growth if non-sterile
- Slight haziness after 3–4 weeks; possible cloudiness
- 10–20% potency loss by day 28
- Standard use window. Discard after 28 days
- Reconstituted at room temperature (20–25°C)
- 24–48 hours
- Rapid peptide unfolding, aggregation, oxidation
- Cloudiness within 48 hours; possible color shift
- 30–50% potency loss within 48 hours
- Avoid entirely. Refrigerate immediately after reconstitution
- Reconstituted and frozen (−20°C or below)
- Not recommended
- Ice crystal formation disrupts tertiary structure
- Cloudiness or particulate after thawing
- 20–40% potency loss per freeze-thaw cycle
- Never freeze reconstituted peptides. Use aliquots instead
- Exposed to direct sunlight or UV light
- Hours to days
- Photooxidation of tryptophan/methionine residues
- Yellow to brown discoloration
- 40–70% potency loss depending on exposure duration
- Store in amber vials or foil-wrapped. Light-sensitive