Understand the source comparison
Semax Amidate for Learning: Research Model Comparison
The following table compares administration protocols, cognitive domains tested, and observed outcomes across published Semax research models. Understanding these parameters helps researchers design protocols aligned with specific learning outcomes. Rodent Mor
No winner is assigned.
This page preserves a source comparison for education. It does not add a rating, recommendation or clinical judgment.
- The following table compares administration protocols, cognitive domains tested, and observed outcomes across published Semax research models. Understanding these parameters helps researchers design protocols aligned with specific learning outcomes.
- Rodent Morris Water Maze (spatial learning)
- 300 mcg/kg, subcutaneous daily
- Spatial memory acquisition & retention
- 28% faster acquisition, 35% better 7-day retention vs control
- 14 days treatment + 7 day retention test
- Gold-standard learning paradigm; outcome aligns with BDNF-mediated synaptic consolidation theory
- Human Digit Span & Verbal Learning (observational)
- 600 mcg intranasal, once daily
- Working memory capacity & verbal recall
- Digit span +1.4 items, verbal learning +18% recall accuracy
- 21 days
- Not placebo-controlled but methodology transparent; effect size moderate (d=0.5–0.6)
- Rodent Novel Object Recognition
- 100 mcg/kg, intranasal pre-training
- Recognition memory & hippocampal-dependent learning
- 42% increased discrimination index vs saline control
- Single-dose acute study
- Demonstrates acute neuroplastic priming effect even without chronic dosing
- Human Continuous Performance Task (CPT)
- 400 mcg intranasal, morning administration
- Sustained attention & response inhibition
- 22% reduction in commission errors, 15% faster reaction time
- 28 days
- Attention outcomes consistent across multiple independent studies; suggests prefrontal circuit strengthening